Testosterone may protect men from stomach inflammation, mouse study suggests. (2021)
From the article:
In researching mice without either glucocorticoids or testosterone, Busada, his research partner John Cidlowski – a senior investigator with the National Institutes of Health – and their colleagues observed that males' stomach inflammation increased as much as the females' did.
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What’s more, when he and his team gave testosterone to the female mice, their inflammation vanished.
“We were able to completely rescue them from their stomach inflammation,” Busada said. “We proved that androgens were the hormones giving male mice that double layer of protection from inflammation. In the females, the only anti-inflammatory hormone was glucocorticoids. In males, it could be either glucocorticoids or androgens. This study potentially explains why women have a much higher incidence of autoimmune and chronic inflammatory diseases.”