A low protein diet caused changes in testicular epigenetics and males had offspring that were overweight with symptoms of type 2 diabetes.
www.pnas.org
A low protein diet (9% of total calories) caused changes in testicular epigenetics and males had offspring that were overweight with symptoms of type 2 diabetes and reduced activation of genes which regulate fat metabolism (mouse study).
The low protein diet changed the testicular expression of many folate-cycle enzymes (ie. Dhfr, Mthfr, and Mtr) and also changed DNA methyltransferases resulting in global hypomethylation.
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This study was done in animals and further research is necessary to determine how much of this study’s findings can be translated to humans.