Serotonin 5-HT2A receptor activation (molecular target of classical psychedelics) suppresses TNF-alpha-induced inflammation with extraordinary potency

FTA:

We have now discovered that activation of 5-HT(2A) receptors in primary aortic smooth muscle cells provides a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-alpha-mediated inflammation. […] With the exception of a few natural toxins, no current drugs or small molecule therapeutics demonstrate a comparable potency for any physiological effect