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    Interestingly, PI3K/AKT/FOXO seem to relevant in development/susceptibility of both acne and depression, this may explain part of the link. Isotretinoin also seem to exert some of it’s effects on this pathway.

    [FOXO & depression] https://www.ncbi.nlm.nih.gov/pmc/articles/26279492

    [FOXO & Acne] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507494/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507494/

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      Interesting correlation. I wonder if it has to do more with teenage hormones, etc… more than body image issues.