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“Defined as taking more than five medications daily, polypharmacy is linked with many adverse health effects, especially among older adults, who are at risk of a "prescription cascade"—where the side effects of drugs can be misdiagnosed as symptoms of another disease, creating a vicious cycle of more drug use.”

“The researchers measured aspects of the participants' cardiovascular health, including flow-mediated dilation (how flexible a blood vessel is), microvascular perfusion rates (how quickly and efficiently tiny blood vessels fill), blood glucose levels, and triglycerides.”

“Supplementation with 14,000 IU/d resulted in a 32% reduction in new brain lesions detected by MRI compared to placebo. This is a much higher dose than the Institute of Medicine recommends as the daily upper tolerable intake (10,000 IU per day).”

“People who drank about three cups (~20 ounces) of green tea daily had 3% less white matter damage in their brains than those who drank just one cup (~7 ounces). Those who drank around seven to eight glasses (~50 ounces) daily had 6% less damage.”

“Although plasma levels of collagen peptides increased among participants taking the supplemental collagen, supplementation did not increase muscle fiber or connective tissue synthesis more than the placebo.”

“According to the National Institutes of Health, the current recommended daily allowance for vitamin D is 600 IU for adults and 800 IU for people over 70 years old. The authors urged patients to ask their health care provider to measure their levels before substantially increasing vitamin D intake.”

“Catabolic crisis can occur at any age but is more common among older adults, for whom injuries, surgeries, or prolonged illnesses dictate long and sometimes frequent periods of physical inactivity or immobilization.”

“The authors' analysis revealed that even after considering sex, body mass index, dietary fiber intake, and blood pressure, lower sodium intake (less than 2,500 mg/day) did not decrease the risk of cardiovascular disease.”

“FoundMyFitness has a wealth of information about the various components used in this intensive protocol, which included: Diet: A whole-food, minimally processed, plant-based diet, high in complex carbohydrates and low in harmful fats and refined sugars.”

“In an attempt to control for the healthy user bias (the possibility that people who take multivitamins may have better lifestyle habits than nonusers), the statistical analyses were adjusted for confounding factors like age, sex, education, alcohol and tobacco use, BMI, physical activity, diet quality, family history of cancer, and the use of other supplements.”