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Links related to the brain.

“This highly controlled fluid movement system is responsible for waste disposal during sleep, injury, and illness because, unlike other organs, the brain has no traditional lymphatic structures. Glymphatic dysfunction disturbs normal pressure in the brain and impairs waste disposal, contributing to neurodegeneration.”

“Lower peripheral levels of BDNF are seen in depression and some forms of anxiety, and restoration of BDNF is a likely result of successful antidepressant treatment. Some small molecules (dinitrophenol and dihydroxyflavone) effectively increase brain BDNF levels or activate BDNF pathways.”

“Certain brain structures, like the hippocampus, are particularly vulnerable, accumulating neurofibrillary tangles, undergoing a reduction in synapses, and losing neurons. The good news is that we can intervene in the process, and one of the most important ways to do this is to keep blood glucose levels in check.”

“Recent clinical evidence suggests that sulforaphane raises levels of the potent antioxidant glutathione in the plasma and brain. In two independent studies, sulforaphane showed promising outcomes, with children and adolescents exhibiting marked reductions in autistic behavior.”

“APOE4 is a common genetic variant associated with increased susceptibility to Alzheimer's disease. In this conversation with Derek, Dr. Rhonda Patrick explains why learning about her own APOE4 status sharpened her attention to brain health, exercise, sleep, and alcohol consumption.”

“Keeping our brains sharp throughout the lifespan is essential for optimal performance. Lifestyle behaviors such as exercise, dietary modification, and sauna use influence brain health.”

“In a study of 1,111 postmenopausal women, a higher red-blood-cell omega-3 index was associated with larger total brain and hippocampal volumes measured eight years later. The hippocampus supports learning and memory, making preservation of this region relevant to cognitive aging.”

“In this FoundMyFitness episode excerpt, Dr. Rhonda Patrick explains that lactate crosses the blood-brain barrier through monocarboxylate transporters. Within the brain, glycolytic astrocytes produce lactate that neurons can import and use as fuel.”