Derek from More Plates More Dates joins Dr. Rhonda Patrick to discuss testosterone optimization. ... hormones cortisol biomarkers alcohol testosterone micronutrients zinc blood test Hair

[toc] Coffee is more than just a morning ritual or a comforting pick-me-up—it's a scientifically supported pathway to improved health, performance, and longevity. As one of the world's most widely consumed beverages, coffee has long been celebrated for its energizing properties. However, emerging research now highlights its remarkable potential to extend lifespan, slow biological aging, and reduce the risk of chronic diseases like heart disease, diabetes, and certain cancers. Coffee reduces the body's biological age by modulating gene expression and protects against cardiovascular events and n... alzheimer's diabetes parkinson's caffeine neurodegeneration cardiovascular metabolism coffee L-Theanine

Dr. Axel Montagne discusses blood-brain barrier dysfunction in dementia and early-stage age-related cognitive decline. ... dementia brain omega-3 memory aerobic blood-brain barrier

“We’ve got 40 years’ worth of data with people on [protein supplementation] now. And we’re not seeing some sort of rife wave of people who used it getting various forms of cancer, etc., which you would expect. Forty years is enough to see the effect.” - Stuart Phillips, Ph.D. on high protein supplementation High protein intake is often believed to be harmful to kidney function, but robust evidence indicates that this concern is unfounded. A 2000 study demonstrated that athletes with high protein consumption do not have an increased risk for kidney dysfunction. Researchers asked bodybuilders a... muscle protein

[toc position='left'] Background Zinc is an essential nutrient that participates in numerous biological processes and modulates the activity of more than 300 enzymes and 2,000 transcription factors.[ref doi='10.1136/bmj.326.7386.409'] First identified for its influence on growth and development, zinc is now understood to play critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. History The importance of zinc in the human diet first became apparent in the early 1960s, after a patient with a rare syndrome presented to Dr. Ananda Prasad, a physic... nutrition interesting zinc

Aging is the progressive accumulation of damage that occurs to an organism over time, eventually leading to disease and death. Findings from a new study suggest that diluting the blood of old mice can reverse some of the deleterious effects of aging. Previous studies have shown that therapeutic plasma exchange via heterochronic parabiosis, a procedure in which two organisms of different ages are joined so that they share a common blood supply, elicits improvements in the older organism and declines in the younger, suggesting that young blood rejuvenates whereas old blood deteriorates. Similar... aging tissue repair neurogenesis

[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage

Cognitive decline is a common feature of aging, affecting more than 16 million people (https://www.cdc.gov/aging/pdf/cognitive_impairment/cogimp_poilicy_final.pdf) living in the United States. Findings from a new study in mice suggest that reducing inflammation in the brain may slow or reverse cognitive decline. Chronic inflammation is a key element of the aging process and drives many age-related diseases and conditions. The blood-brain barrier (BBB) is critical to healthy brain function, but chronic, systemic inflammation may cause changes in the BBB, allowing toxic blood-borne molecules to ... aging protein

Dr. Elissa Epel discusses the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health. ... telomeres nutrition diet epigenetics aging stress meditation

Nine blood biomarkers used to identify a "phenotypic age" was highly predictive of remaining life expectancy among both healthy and unhealthy populations independent of chronological age. However, the phenotypic age was better at predicting lifespan in younger people compared to older individuals. Phenotypic age also increased as a function of diseases a person had, suggesting that phenotypic age can be different than chronological age based on these biomarkers. The nine biomarkers included: albumin, creatinine, glucose, C-reactive protein, lymphocyte percent, mean cell volume, red blood cell ... aging protein