[toc] Urolithin A is a postbiotic—a compound our gut microbes can form from ellagitannins and ellagic acid, polyphenols found in foods such as pomegranates, strawberries, and walnuts. Because production depends on the presence of specific gut microbes, people fall into distinct "metabotypes" (A = good UA producers, B = partial producers, 0 = non-producers), and only a minority make large amounts from diet alone. Therefore, purified UA supplements bypass that microbiome variability.[ref doi='10.3389/fmicb.2017.01521'] Mechanistically UA is best known as an inducer of mitophagy—the selective au... immune system gut aging prebiotics urolithin a microbiome

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda vitamin d aging coffee curcumin caffeine bone calcium polyphenol supplements

A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as ... ... aliquot alzheimer's gut inflammation intestinal permeability cardiovascular endotoxemia

In this clip, Dr. Eran Elinav discusses the intestinal barrier's important role in absorbing nutrients while keeping out pathogens. ... microbiome gut probiotics fiber

Dr. Eran Elinav discusses the complex interactions between humans and their resident gut microbiomes. ... microbiome obesity metabolism heart disease diabetes intestinal permeability autoimmunity