Q&A #40 with Dr. Rhonda Patrick (10/01/2022)
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In this Q&A and accompanying show notes, we explore the potential longevity benefits and tradeoffs of rapamycin, the effects of polyphenols on cognition, the variability of urolithin A production in the gut, and more.
We also discuss:
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Coffee alternatives for people who can't tolerate caffeine
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How to increase and maintain bone density with age
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The benefits of Apigenin for sleep
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Whether fat can improve the bioavailability of quercetin and luteolin
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The best way to take a curcumin supplement
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Supplements to prioritize on a budget
Is rapamycin an effective and safe way to increase longevity?
"I would be stunned if rapamycin had similar lifespan-extending effects in humans like it does in lab mice in sterile environments."- Dr. Rhonda Patrick Click To Tweet
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Beginning of Q&A
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Q: Are there any coffee alternatives for people who can't tolerate caffeine?
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Genetic report 1
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Polyphenol topic page 1
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Q: Does Apigenin have any benefits for sleep? 1
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Q: Can the microbiome convert pomegranate to Urolithin A? 1
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Q: What is the best way to take a curcumin supplement?
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Q: What is the GRAIL "liquid biopsy" test?
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Q: Supplements to prioritize on a budget
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Watch previously recorded Q&As with Dr. Rhonda Patrick
Q&A #75 with Dr. Rhonda Patrick (11/01/25)
Dr. Rhonda Patrick discusses joint aging prevention, avoiding heavy metals in protein, reducing migraines, nicotinamide for skin, and minimizing jet lag.
Q&A #74 with Dr. Rhonda Patrick (10/11/25)
Dr. Rhonda Patrick discusses stroke risk, eczema, immune resilience, her new smoothie recipe, and whether everyone should cut out gluten.
Q&A #73 with Dr. Rhonda Patrick (8/16/25)
Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.
Q&A #72 with Dr. Rhonda Patrick (7/19/25)
Dr. Rhonda Patrick discusses fragmented sleep, lipid biomarkers including ApoB and LP(a), coffee makers and bean quality, and choline supplementation.
Q&A #71 with Dr. Rhonda Patrick (6/7/25)
Dr. Rhonda Patrick discusses her supplement routine, Neu5Gc risks, Repatha and diabetes, heat stress, osteoporosis in men, and plyometrics.