How Time-Restricted Eating affects leaky gut and systemic inflammation | Satchin Panda
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In this clip, Dr. Satchidananda Panda of the Salk Institute touches on a lot of material but focuses on the practical implementation of time-restricted eating, featuring a few of the most frequent questions that came after our first conversation on FMF. Dr. Panda discusses the effects of time-restricted feeding on systemic inflammation; time-restricted eating as an opportunity for night-time repair that may prevent intestinal hyperpermeability (i.e., leaky gut), a primary source of systemic inflammation; and how the timing of macronutrients may differentially affect gut permeability.
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An organism’s ability to maintain its internal environment within defined limits that allow it to survive. Homeostasis involves self-regulating processes that return critical bodily systems to a particular “set point” within a narrow range of operation, consistent with the organism’s survival.
Experimental evidence from animal models links gut flora, an increase in intestinal permeability and endotoxemia of intestinal origin to low-grade chronic inflammation and obesity in animals.
Restricting the timing of food intake to certain hours of the day (typically within an 8- to 12-hour time window that begins with the first food or non-water drink) without an overt attempt to reduce caloric intake. TRE is a type of intermittent fasting. It may trigger some beneficial health effects, such as reduced fat mass, increased lean muscle mass, reduced inflammation, improved heart function with age, increased mitochondrial volume, ketone body production, improved repair processes, and aerobic endurance improvements. Some of these effects still need to be replicated in human trials.
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Time-restricted eating News
- Late-night eating increases weight gain, raised insulin, fasting glucose, cholesterol & triglycerides in small trial.
- Time-restricted eating and longer daily fasting times improved health and longevity independent of calories or diet composition in male mice.
- Time-restricted eating (breakfast 90 min later and dinner 90 min earlier) for 10 weeks resulted in improved blood glucose levels and twice as much fat
- People that have their deep sleep cycle disrupted for one night experience a 10% increase in amyloid plaque levels.
