I would like to know the benefit correlation between mice and humans.
If this diet allows a mouse to live 20% longer could this help a human live 10% longer.
Agreed. Keep in mind that a 48 hour fast in mice results in a 20% reduction in body weight whereas it results in a 1-2% reduction in body weight in humans. Perhaps a stricter TRE plus prolonged fasting in humans may move the needle a little more…
Hells Yeah this is awesome. Tim Ferriss has also stated that he takes Astaxanthin for its ability to act as sun screen. I would rather take Astaxanthin than put on sunscreen myself :D
Maybe you’d find coating yourself in broccoli extract preferable?
What happens when you democratize science and give anyone the ability to edit DNA?
There is no Multivitamin that if going to be a good fit. If everything in the Multivitamin was 100% of the daily recommended value it is going to be way too low in many things. Your best bet is to buy each vitamin / supplement individually and take the does you believe to be most aligned with your health goals. This can be pretty time consuming though.
longevity / life extension ,
Those are all the tags I could think of.
Added a couple of these and a few others: sleep, nootropics, hormones, metabolism, performance
bio-tech is pretty close to technology (which is there)… longevity / life extension is pretty close to aging (which is there), so I left those out.
@KickAssBrockSamson Hope they can get past CA laws. I called theranos up to find out if I needed a prescription to use their tests that have at Walgreens in Palo Alto. Turns out I need a doc but they are trying to get around that. I would like to compare the precision of theranos compared to labcorp.
Very interesting. I would like to be able to by pass the doctor completely and just get personal labs done.
The Recommended Dietary Allowance (RDA) for vitamin D is ten times lower than what we actually need, say two teams of researchers who have challenged the US’s National Academy of Sciences (NAS) and the Institute of Medicine (IOM), both responsible for the RDA.
So many excellent quotes in this podcast… Here’s just a few (timestamp links to the spot in the vid).
Markdown in pastebin.
Thanks for that!
However, I believe
“Folic acid does the same thing as radiation.” - Bruce Ames
“Folic acid deficiency does the same thing as radiation.” - Bruce Ames
That said, perhaps best to get folate via the diet rather than supplemental folic acid perhaps:
Folic acid supplementation and colorectal cancer risk: a meta-analysis
Thanks for the correction… someone else reported on the youtube page, but I forgot to fix it here!
@carlsonbjj Just saw you posted this! I just read the paper and tweeted it. Pretty interesting how β-hydroxybutyrate inhibits the inflammasome formation in macrophage cells and this is responsible for anti-inflammatory effect of fasting (also exercise and ketogenic diet). This mechanism is independent of AMPK and Sirt1.
That is awesome!
I think we should do away with the FDA all together and let the free market take over. Companies like Google’s Calico and 23andMe would quickly change the world for the better.
I have read of myostatin inhibitors before. This is pretty sweet and new approach to muscle building that does not rely on AAS. Now it is time to get my hands on some ActRIIB :)
This is a very interesting study. I wonder if one should just supplement with a nitric oxide supplement to get the same if not improved outcome. Now how much nitric oxide should I take on daily basis?
I’ve studies where nitric oxide supplementation is not as beneficial as nitrates from vegetables, particularly in athletes.
@KickAssBrockSamson Worms and mice are one thing but humans are another: Ibuprofen increases the risk of stroke by 3-fold in humans. http://www.theguardian.com/science/2011/jan/12/high-doses-painkillers-stroke-risk
Damn thats no good.
@KickAssBrockSamson I did not know that Nrf1/2/3 (human equivalent of SKN-1) regulates collagen-related genes. One more reson why EGCG and polyphenols (which all activate nrf2) are awesome.
Hells Yeah! We are going to stay young forever :D
More details here http://www.nature.com/nature/journal/v515/n7528/full/nature13904.html
@KickAssBrockSamson I talked about this in great detail in the podcast I did with Tim Ferriss.
I love all the podcasts that you do.
Does anyone know of the compound that Sinclair used to stimulate NAD in his research? It’s riddled in secrecy. @kickAssBrockSamson, @dan
@programmer_Ali @KickAssBrockSamson @dan The molecule that was used in this study is called nicotinamide mononucleotide (NMN) and it is a precursor of NAD, which regulates diverse biological processes, including, metabolism, aging, circadian rhythm, and axon survival. Actually, resveratrol (which Sinclair previously identified to extend lifespan, also increases NAD levels. Caloric restriction is another way to increase NAD levels and extend lifespan. I’m particularly interested in whether NMN cross the blood-brain barrier and if so, whether it gets converted into NAD. If it gets converted into NAD, this can repair damage to axons (GREAT) but if not it can cause axon degeneration. I think this is important to figure out before NMN supplementation.
@rhonda @KickAssBrockSamson @dan
It looks like Sinclair is confident about no axon degeneration occurring from his research. He has already patented and is selling a commercial product of 250mg NMN named Niagen-> http://livecellresearch.com/niagen/
Furthermore other companies are already commercializing the stuff->
NMN causing axon degeneration worries me. I know one can buy straight NAD+. That way you would not have to worry if the enzyme that converts NMN to NAD+ is absent. With that said I do not know how much one should take of NAD+ on a daily basis.
There is no known mammalian transporter for NAD+. In other words it doesn’t enter cells. It’s too big of a molecule. You need to take a precursor that converts into NAD+
How would one know if NMN passes the BBB and if it gets converted? What would be the mechanism behind NMN causing axon degeneration?
Niacinamide is transported across BBB but I’m not sure about supplemental NMN. When injected into rats, NMN causes Wallerian degeneration of axons but only when the enzyme that converts NMN to NAD+ is absent. I’m just not sure we know enough about supplemental NMN it terms of how much gets into the brain, what concentration saturates the NMNAT enzyme so that NMN begins to accumulate.
:) What is the enzyme? Couldn’t one just simply inject a form of NAD? Or simply just simply IV NMN? My understanding of what you are saying is that there is good knowledge of injected NMN,
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