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Comments by KickAssBrockSamson
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      I would like to know the benefit correlation between mice and humans. If this diet allows a mouse to live 20% longer could this help a human live 10% longer.

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        Agreed. Keep in mind that a 48 hour fast in mice results in a 20% reduction in body weight whereas it results in a 1-2% reduction in body weight in humans. Perhaps a stricter TRE plus prolonged fasting in humans may move the needle a little more…

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        Hells Yeah this is awesome. Tim Ferriss has also stated that he takes Astaxanthin for its ability to act as sun screen. I would rather take Astaxanthin than put on sunscreen myself :D

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          What happens when you democratize science and give anyone the ability to edit DNA?

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            There is no Multivitamin that if going to be a good fit. If everything in the Multivitamin was 100% of the daily recommended value it is going to be way too low in many things. Your best bet is to buy each vitamin / supplement individually and take the does you believe to be most aligned with your health goals. This can be pretty time consuming though.

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              Tag Name: longevity / life extension , bio-technology, nootropics, performance enhancement, stem-cells, hormone therapy

              Those are all the tags I could think of.

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                Added a couple of these and a few others: sleep, nootropics, hormones, metabolism, performance

                bio-tech is pretty close to technology (which is there)… longevity / life extension is pretty close to aging (which is there), so I left those out.

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                  @KickAssBrockSamson Hope they can get past CA laws. I called theranos up to find out if I needed a prescription to use their tests that have at Walgreens in Palo Alto. Turns out I need a doc but they are trying to get around that. I would like to compare the precision of theranos compared to labcorp.

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                    Very interesting. I would like to be able to by pass the doctor completely and just get personal labs done.

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                    The Recommended Dietary Allowance (RDA) for vitamin D is ten times lower than what we actually need, say two teams of researchers who have challenged the US’s National Academy of Sciences (NAS) and the Institute of Medicine (IOM), both responsible for the RDA.

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                      So many excellent quotes in this podcast… Here’s just a few (timestamp links to the spot in the vid).

                      • 4:18 - “Folic acid does the same thing as radiation.” - Bruce Ames
                      • 10:35 - “When you get a little low on any vitamin or mineral, it’s to nature’s benefit to ration it. Where would you expect it to ration it if you don’t have enough selenium, or Vitamin K, or magnesium? Well, it’s going to put it into those proteins that are essential for survival, because what nature wants you to do: survive and reproduce. Thats strong selection. Living to ninety? Nature doesn’t really care about about that, because you’re past your reproductive age.” - Bruce Ames (on insidious micronutrient deficiency causing aging or “The Triage Theory”)
                      • 14:37 - “For example, in Vitamin K, the clotting proteins get it first… and only after they’re satisfied do you prevent calcification of the arteries, or prevent cancer, or prevent bone fractures. It’s all insidious damage that you get that’s a long term consequence. In fact, we call these the diseases of aging.” - Bruce Ames (on The Triage Theory in selenium and vitamin k dependent proteins)
                      • 22:13 - “Over the years we’ve discovered these 15 vitamins, and 15 essential minerals… but it’s all based on some disease that shows up or people dying.” - Bruce Ames (on longevity vitamins and the trouble with using only acute symptoms for defining essential nutrients)
                      • 23:20 - “I have an italian wife who feeds me a wonderful diet. She kept on nagging me that I should get more exercise. One day I said: when I feel like exercise I run my experiments, I skip controls, and I jumps to conclusions! I liked that joke so much I must have told her it fifty times and one day she said, "I’ve heard enough of that joke, I’m getting you a personal trainer!” So now I go and work out twice a week.“ - Bruce Ames (on his exercise habits)
                      • 24:24 - “The EAR (estimated average requirement) is actually set two standard deviations lower than the RDA and people still aren’t even meeting that.” - Rhonda
                      • 25:25 - “What you want to know is… does it shorten your life? You can do those kinds of questions in mice, but those are expensive to do and no one’s been really doing them.” - Bruce Ames (on studying deviations from optimal micronutrient intake)
                      • 31:05 - “The obese are eating the worst diet in the country if you define worse as ratio of calories to essential micronutrients. They’re just eating empty calories.” - Bruce Ames
                      • 36:46 - “The docs are all used to randomized double-blind clinical trials, which makes a lot of sense because if you test a drug in people, no one has it to start with! But… applying it mindlessly to nutrition is stupid, because if 90% of the population has enough of Vitamin X and 10% are really deficient, you want to test it on that 10% otherwise you’ll never see anything because you’re diluting [your results] with the 90% that have enough.” - Bruce Ames (on the problem of randomized double-blind clinical trials in nutrition)
                      • 38:12 - “Medicine has sort of abdicated [their responsibility]: most physicians know nothing about nutrition. They don’t get any training in medical school… maybe an hour or two lecture. […] I think prevention is going to involve different people. It’s going to involve people who know some nutrition and can figure out mechanism. The analytical methods are coming fast so that you’ll be able to put your finger in a machine and it will send the results to your iPhone.” - Bruce Ames
                      • 42:05 - “If I don’t eat veggies with a meal, I feel deprived.” - Bruce Ames
                      • 42:15 - “I think we all should try and eat a good diet. It’s actually a wonderful to eat a good diet, because you’re eating all of these different kinds of foods… and they all taste good, and when you get used to it, you feel better!” - Bruce Ames

                      Markdown in pastebin.

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                        Thank You!

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                          Thanks for that!

                          However, I believe

                          “Folic acid does the same thing as radiation.” - Bruce Ames

                          Should be

                          “Folic acid deficiency does the same thing as radiation.” - Bruce Ames

                          That said, perhaps best to get folate via the diet rather than supplemental folic acid perhaps:

                          Folic acid supplementation and colorectal cancer risk: a meta-analysis

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                            Thanks for the correction… someone else reported on the youtube page, but I forgot to fix it here!

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                          @carlsonbjj Just saw you posted this! I just read the paper and tweeted it. Pretty interesting how β-hydroxybutyrate inhibits the inflammasome formation in macrophage cells and this is responsible for anti-inflammatory effect of fasting (also exercise and ketogenic diet). This mechanism is independent of AMPK and Sirt1.

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                            That is awesome!

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                            I think we should do away with the FDA all together and let the free market take over. Companies like Google’s Calico and 23andMe would quickly change the world for the better.

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                              I have read of myostatin inhibitors before. This is pretty sweet and new approach to muscle building that does not rely on AAS. Now it is time to get my hands on some ActRIIB :)

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                                This is a very interesting study. I wonder if one should just supplement with a nitric oxide supplement to get the same if not improved outcome. Now how much nitric oxide should I take on daily basis?

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                                  I’ve studies where nitric oxide supplementation is not as beneficial as nitrates from vegetables, particularly in athletes.

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                                  @KickAssBrockSamson Worms and mice are one thing but humans are another: Ibuprofen increases the risk of stroke by 3-fold in humans. http://www.theguardian.com/science/2011/jan/12/high-doses-painkillers-stroke-risk

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                                    Damn thats no good.

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                                    @KickAssBrockSamson I did not know that Nrf1/2/3 (human equivalent of SKN-1) regulates collagen-related genes. One more reson why EGCG and polyphenols (which all activate nrf2) are awesome.

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                                      Hells Yeah! We are going to stay young forever :D

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                                          @KickAssBrockSamson I talked about this in great detail in the podcast I did with Tim Ferriss.

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                                            I love all the podcasts that you do.

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                                            Does anyone know of the compound that Sinclair used to stimulate NAD in his research? It’s riddled in secrecy. @kickAssBrockSamson, @dan

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                                              @programmer_Ali @KickAssBrockSamson @dan The molecule that was used in this study is called nicotinamide mononucleotide (NMN) and it is a precursor of NAD, which regulates diverse biological processes, including, metabolism, aging, circadian rhythm, and axon survival. Actually, resveratrol (which Sinclair previously identified to extend lifespan, also increases NAD levels. Caloric restriction is another way to increase NAD levels and extend lifespan. I’m particularly interested in whether NMN cross the blood-brain barrier and if so, whether it gets converted into NAD. If it gets converted into NAD, this can repair damage to axons (GREAT) but if not it can cause axon degeneration. I think this is important to figure out before NMN supplementation.

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                                                How would one know if NMN passes the BBB and if it gets converted? What would be the mechanism behind NMN causing axon degeneration?

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                                                  Niacinamide is transported across BBB but I’m not sure about supplemental NMN. When injected into rats, NMN causes Wallerian degeneration of axons but only when the enzyme that converts NMN to NAD+ is absent. I’m just not sure we know enough about supplemental NMN it terms of how much gets into the brain, what concentration saturates the NMNAT enzyme so that NMN begins to accumulate.

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                                                    :) What is the enzyme? Couldn’t one just simply inject a form of NAD? Or simply just simply IV NMN? My understanding of what you are saying is that there is good knowledge of injected NMN,

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                                                  @rhonda @KickAssBrockSamson @dan It looks like Sinclair is confident about no axon degeneration occurring from his research. He has already patented and is selling a commercial product of 250mg NMN named Niagen-> http://livecellresearch.com/niagen/ Furthermore other companies are already commercializing the stuff-> http://seekingalpha.com/instablog/10572281-secfilings-com/1990542-niagen-nicotinamide-riboside-offers-huge-potential-as-next-generation-niacin. Thoughts?

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                                                    NMN causing axon degeneration worries me. I know one can buy straight NAD+. That way you would not have to worry if the enzyme that converts NMN to NAD+ is absent. With that said I do not know how much one should take of NAD+ on a daily basis.

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                                                    Thanks!