Oleic acid produced by cells in the brain (and found in olive oil) may be a key cell proliferation and neurogenesis signal
“Findings from a recent study suggest that brain-derived oleic acid activates neural stem cells in the hippocampus, promoting neurogenesis – the generation of new neurons. The hippocampus is a small organ located within the brain's medial temporal lobe.”
OpenAI has created an AI model for longevity science
“OpenAI has developed a new protein-engineering model that enhances the efficiency of Yamanaka factors—proteins used to reprogram human cells into stem cells. This project marks OpenAI's first venture into biological research.”
Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging.
“This 2023 study found that exercise dampened inflammatory pathways and restored immune function in old animals.”
Lactate rejuvenates immune cells that target cancer.
“They found that the cells' uptake and subsequent metabolism of lactate increased. In addition, lactate inhibited the activity of histone deacetylases, and in turn, promoted the cells' stemness – the strictly controlled molecular processes that drive stem cell self-renewal and replication.”
Higher coffee consumption is associated with longer telomeres, which are a biological marker for healthy aging.
“Telomeres are tiny caps on the end of our chromosomes that protect DNA from damage. Telomeres get shorter each year until they reach a critical length which causes the cell to either die or become senescent (metabolically inactive). When this occurs in stem cells, it leads to tissue aging.”
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