Search results for dna damage

“Current evidence suggests that lifestyle factors like diet influence the progression of cognitive decline by increasing or decreasing oxidative stress that damages the brain. Previous studies have demonstrated the association between telomere length, a marker of DNA integrity, and mild cognitive impairment or Alzheimer's disease progression.”

“Glutathione scavenges harmful reactive molecules, thereby preventing damage from oxidative stress, but evidence suggests glutathione levels decrease with aging, contributing to many aging-related diseases.”

“For example, methamidophos, a type of pesticide, damaged the barrier and disturbed sperm production in rodents. Similarly, bisphenol AF, a compound used in plastic manufacturing, damaged sperm DNA and induced genetic and epigenetic changes in fish.”

“Inadequate micronutrient availability can disrupt these systems, contributing to chronic inflammation, oxidative damage, and metabolic strain, all processes linked to accelerated biological aging.”

“Microglia are the brain’s resident immune cells. They serve an essential role in maintaining brain microenvironment homeostasis. Acute activation of microglia modulates inflammation and neurotoxicity, but chronic activation promotes brain inflammation and damage.”

“Telomeres are short, repetitive sequences of DNA located on the ends of chromosomes. They form a protective "cap" – a sort of disposable buffer that gradually shortens with age – that prevents chromosomes from losing genes or sticking to other chromosomes during cell division.”

“Aging involves a progressive decline in the body’s ability to heal from damage (a property known as resilience) and a gradual increase in the risk of age-related diseases like cancers, diabetes, and cardiovascular diseases.”

“In liver samples from 36 cancer patients in high-exposure hotspot areas, the researchers found a distinct pattern of gene activity associated with non-genotoxic carcinogens, substances that promote cancer by disrupting cell function rather than directly damaging DNA.”

“In this video I gave a keynote lecture at the orthomolecular medicine congress in Bussum, Netherlands and discussed my data showing that obese individuals have more than twice the amount of DNA damage in their peripheral blood cells compared to lean individuals.”

“00:50:10 - Werner's syndrome involves excessive telomere shortening. 00:53:33 - Explains how aging is a function of DNA damage and discusses DNA damage assay (test) that Rhonda performs. 00:55:30 - Obesity link to increased DNA damage.”