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“The effect also held up equally in men and women, as well as across different age groups. Further interesting observations emerged when the researchers examined brain scans of more than 17,500 of the study's participants.”

“The investigation was part of the Walnuts and Healthy Aging study, an intervention study of health and cognition in approximately 700 healthy older adults (63 to 79 years old) recruited from diverse geographical locations in the United States and Spain.”

“Misfolded proteins tend to clump together and are believed to be the primary cause of a wide range of diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease ("mad cow" disease), cystic fibrosis, and many other disorders.”

“The investigators searched for evidence of potential causality in the association between inflammatory cytokines and altered brain structure using Mendelian randomization, a research method that provides evidence of links between modifiable risk factors and disease based on genetic variants within a population.”

“Even so, it highlights reduced cortical choline as a consistent pattern across anxiety disorders and an interesting target for future mechanistic and supplementation trials. In Aliquot #67, I talk about the role of choline in metabolic and brain health.”

“This is a very interesting interview with Dr. Pierre Capel who explains how certain breathing techniques (such as those used in yoga) can change pain sensitivity by temporarily increasing blood pH. This hour long interview is loaded with interesting information including how social isolation in rats prone to cancer increases tumor incidence by 60%. Lots of good stuff here...hope you enjoy it!”

“A 2019 study found that intensive blood pressure control in patients with hypertension reduces the risk of developing small blood vessel damage-related white matter lesions in the brain.”

“The mechanism of action by which aspirin helps prevent cardiovascular events is via its inhibition of the activity of enzymes involved in the production of thromboxane, a substance made by platelets that causes platelet aggregation – an important stage in the atherogenic process – as well as blood clotting and blood vessel constriction.”

“Brain networks involved in higher-level functions such as self-related thought, flexible thinking, and staying focused on goals became more strongly linked with networks that process vision and body movement. This was the most consistent shared effect across the full dataset.”

“Finally, and particularly interesting, an increased blood ph to 7.75 (in some cases) via reduced decreased carbon dioxide blood levels. This is known as (mild) respiratory alkalosis, which hint at some very interesting possibilities that might explain why Wim's technique helps him to endure the cold more, as well as how he was able to suppress his inflammatory response to endotoxin himself.”