Apolipoprotein E is predictive of Alzheimer's risk even in individuals without the E4 allele
“The brains of people who die with dementia-related disorders often exhibit the presence of many types of misfolded proteins. APOE is a protein involved in lipid transport. A variant in the APOE gene, called apolipoprotein E4 (APOE4), is the major genetic risk factor for Alzheimer's disease.”
Using sauna 4-7x per week lowered dementia risk by 66% & Alzheimer's risk by 65% after adjusting for diet/lifestyle.
“One of the reasons I find this study so compelling even though it is associative data and does not establish causality is because the sauna activates heat shock proteins, which have been shown in countless animal studies to play a causal role in preventing Alzheimer's disease and other neurodegenerative diseases.”
Transplanting blood cells from young mice into old mice prevented cognitive decline by halting the activation of a type of immune cell in the brain.
“There are a couple of clinical studies underway that are looking at transplanting blood from young individuals into older individuals with mild cognitive dementia to see how this affects cognitive function.”
Higher levels of omega-3s in mid-life protect the brain from shrinkage and preserve cognitive function.
“The fatty acids may also protect the brain against white matter hyperintensities – areas in the brain that often indicate cerebral small blood vessel disease, a risk factor for dementia.”
Increased in memory biomarker Cathepsin B confirms aerobic exercise helps cognitive function in older adults
“The present correlation between CTSB and verbal learning and memory suggests that CTSB may be useful as a marker for cognitive changes relevant to hippocampal function after exercise in a population at risk for dementia.[...]”
Testosterone-lowering drugs increased the risk of dementia by 2-fold in men with prostate cancer compared to men that were untreated.
“Another study found that prostate cancer patients randomized to either active monitoring, surgery or radiation therapy all had the same risk of death from the cancer after 10 years. These results suggest that active monitoring of prostate cancer patients may be as good as early radical treatment and may cause fewer side effects.”
Does resistance training in older adults lead to structural brain changes associated with a lower risk of Alzheimer's dementia? A narrative review
“However, resistance exercise elicits structural changes in brain regions affected by Alzheimer's, including those involved in communication, coordination, and memory, such as the cingulate white matter tracts and the hippocampus.”
Age-related brain shrinkage is slower among non-industrialized populations.
“The brain shrinks with age, a process called brain atrophy, and a faster rate of shrinkage is associated with dementia and cognitive and functional impairments. Heart disease risk factors such as high cholesterol, diabetes, and hypertension are common in industrialized populations and increase the risk of brain atrophy.”
Magnesium may delay age-related brain shrinkage.
“More than half of people living in the United States likely have magnesium deficiency These findings suggest that magnesium protects the brain against age-related volume losses, which are associated with dementia.”
Results 161–170 of 423