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“But with their rise in popularity come important questions about long-term effects and safe use. In this Aliquot, I discuss how these drugs work, their pros and cons, the latest research, and lifestyle strategies to optimize their effects for long-term health.”

“A growing body of evidence suggests that metformin, a drug commonly used for the treatment of type 2 diabetes, is associated with a reduced risk of developing or dying from several types of cancer in adults with diabetes.”

“GLP-1 is a gut-derived satiety signal. Agonist drugs prolong that signal, slow gastric emptying, and act on appetite circuits, which can reduce food intake but can also cause nausea, constipation, or other gastrointestinal effects.”

“Some researchers have hypothesized that since antihypertensive drugs like ACE inhibitors and angiotensin II receptor blockers, or ARBs, increase ACE2, they might alter the risk of severe COVID-19 disease.”

“Cholesterol-lowering drugs can act at several points in the body's handling of lipoproteins. Dr. Rhonda Patrick compares PCSK9 inhibitors, bempedoic acid, and ezetimibe, focusing on how they reduce circulating LDL and apoB-containing particles.”

“Social drugs like caffeine, cannabis, alcohol, and nicotine also get into breast milk. While the alcohol concentration in breast milk is low, infants cannot metabolize it very well and can cause altered sleep habits, decreased appetite, weight gain, low blood sugars, and impaired motor development.”

“Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and others.”

“However, dietary strategies, pharmaceuticals, and some supplements may reduce ApoB levels. In this Aliquot – a follow-up to Aliquot #81 – Dr. Peter Attia and I talk about some of the nutritional, pharmaceutical, and supplemental approaches to reduce ApoB.”

In this clip, Dr. Roland Griffiths describes the current state of research on psychedelic drugs.