Search results for epigenetics

“This is seen in supercentenarians and their offspring, who tend to age slower than their younger counterparts. Furthermore, the rate of epigenetic aging is stable over the lifespan, suggesting that people who age slowly at 20 years will age slowly at 60 years.”

“Nutritional status plays a critical role in aging. Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging. In this clip, Dr. Steve Horvath describes evidence suggesting that supplemental vitamin D or omega-3 fatty acids slow epigenetic aging.”

“In this clip, Drs. Levine and Patrick discuss the advantage of using epigenetic clocks in aging research to measure biological age. Dr. Levine then explains the difference between first and second-generation epigenetic aging clocks.”

“Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging.”

“Chronic inflammation as a contributor to aging is not an especially new idea. Here, too, epigenetic clock evidence does seem to see this relationship. There is also evidence that HIV accelerates epigenetic aging.”

“Obesogenic diets appear to accelerate epigenetic aging, contributing to metabolic dysfunction across multiple generations. Conversely, animal studies suggest that caloric restriction may slow epigenetic aging.”

“Interfering with the enzymes that carry out these two opposing processes can play critical roles in epigenetic age, ultimately affecting aging, disease, and death. In this clip, Dr. Steve Horvath describes how altering the activity of enzymes that facilitate methylation and demethylation affects epigenetic age.”

“Although epigenetic clocks clearly relate to causal aspects of aging, scientists don't know if the clocks are inherently causal. At this time, the clocks are not validated for use as clinical biomarkers for individual use, but rather to look at trends across larger studies.”

“As techniques are developed to differentiate and transdifferentiate cells from one cell type, such as a fibroblast, into another, such as a neuron, interesting patterns of effects on epigenetic age are revealed. Listen as Dr. Steve Horvath discusses nuances of epigenetic age in the context of cellular differentiation and aging experiments in the lab.”

“In this clip, Dr. Elissa Epel explains how these aging syndromes – as well as other factors that affect telomere length – can also be passed to offspring via epigenetic mechanisms.”