Search results for telomeres

“However, the DNAm GrimAge epigenetic clock is a highly reliable predictor of healthspan and lifespan, based on DNAm surrogates in blood, including biomarkers of aging and alterations in blood composition. In this clip, Dr. Steve Horvath discusses the strengths and weaknesses of using telomeres versus epigenetic clocks to predict risk of disease and death.”

Dr. Elissa Epel describes the exposome – the totality of non-genetic exposures a person experiences during a lifetime – and explains how it affects telomeres.

“Having longer telomeres is associated with better health and longer lifespan. Some research suggests that dietary supplements might offer a means to lengthen telomeres. Candidates include vitamin D, omega-3 fatty acids, and TA-65, a product that purportedly contains extracts of astragalus membranaceus, a plant-based compound that demonstrates anti-aging effects.”

“Accelerated aging syndromes, such as Werner syndrome and Hutchinson-Gilford progeria syndrome, are characterized by genetic mutations that promote increased DNA damage, particularly at telomeres.”

“Telomerase, an enzyme that extends the length of telomeres, is critical to healthy cellular aging. But having too much telomerase – as in the case of cancer cells – can be a bad thing. Cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal.”

“Second, psilocybin has clinically documented antidepressant and stress-reducing effects. Therefore, if psilocybin reduces depression, and depression shortens telomeres, then psilocybin may help preserve or even lengthen telomeres.”

“Telomerase, a reverse transcriptase enzyme, adds specific nucleotide sequences to the ends of existing chromosomes, extending the telomere. Telomerase activity is highly regulated during development, and its activity is almost undetectable in fully developed cells.”

“Telomerase, an enzyme that extends the length of telomeres, is critical to healthy cellular aging due to its capacity to lengthen telomeres. But telomerase also prevents cells from becoming senescent, a state that can occur when a cell is damaged, in which it no longer replicates (divides) and is not metabolically active.”

“A growing body of scientific evidence suggests that there's a correlation between nutrition, exercise, sleep, and stress management and having longer telomeres. Identifying the mechanisms that drive these correlations has proven challenging, but a few candidates stand out, including improvements in immune function and metabolic health.”

“Hyperbaric oxygen trial discovered a lengthening of up to 38% of the telomeres, decrease of up to 37% in senescent cells in certain cell populations. With age, tissues lose their ability to function properly, leading to an increased risk of cancer, cardiovascular disease, Alzheimer's disease, and other chronic diseases.”