Search results for blood-brain barrier

“Air pollution leaves a biological fingerprint on our lungs, our blood vessels, and even our brains, eroding the body's defenses, triggering inflammation, weakening the blood-brain barrier, and accelerating cognitive decline.”

“These findings remain emerging and do not prove long-term dementia prevention. Dr. Patrick presents increased blood-flow shear at the blood-brain barrier influencing VEGF and BDNF through mechanosensing as a proposed mechanism, and clinical confirmation is limited.”

“Maintaining early healthy blood pressure is critical to ensuring the proper functioning of blood vessels in the brain and blood-brain barrier integrity. Cumulative exposure to high blood pressure damages blood vessels and increases dementia risk.”

“Consuming alcohol may be more detrimental to those with an APOE4 allele as they are less able to repair the damage inflicted on the brain. In addition, eating refined carbohydrates and added sugars contributes to the inflammatory molecules that can cross the blood-brain barrier.”

“Chronic inflammation is a major driver in the breakdown and leakiness of the blood-brain barrier. The pericyte cells, guardians of the barrier, have to physically get out of the way to respond to neuroinflammation, letting immune cells in and ultimately promoting leaks; this leads to a vicious cycle, culminating in the loss of capillaries and neurons.”

“Furthermore, emerging research underscores the importance of shear force in blood flow and its impact on neurotrophic factors like BDNF and VEGF at the blood-brain barrier. In this clip, Dr. Martin Gibala examines the cognitive benefits of HIIT and the emerging insights on lactate's role in brain health.”

“Docosahexaenoic acid (DHA), an essential omega-3 fatty acid, promotes health and development of the brain. DHA crosses the blood-brain barrier either by passive diffusion or active transport. Passive diffusion declines with age, following a traumatic brain injury, or in people with the APOE4 gene.”

“Lactate, which is produced during exercise, acts similarly to ketones, and under conditions of hypoxia (which can occur during exercise), it can be used as an alternate fuel source. In particular, lactate crosses the blood-brain barrier for use by neurons as an energy source.”

“Preclinical research suggests that this can be accomplished by feeding animals an IGF-1 promoting diet, in conjunction with antibodies against the IGF-1 receptor which are unable to cross the blood-brain barrier.”

“Dr. Patrick treats magnesium L-threonate separately. Early human findings are limited by small studies, industry funding, and products that sometimes include coingredients, making it difficult to attribute effects to L-threonate alone.”