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What FoundMyFitness Has Covered
PremiumCRISPR is a powerful gene-editing technology that can target disease-causing genes, with preclinical work and early human trials pointing toward therapeutic applications. Studies described include correction of mutations associated with muscular dystrophy and other serious diseases,…
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Based on available source text from 9 of the first 10 results.
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Going beyond CRISPR with 1 million edits per cell │ Dr. George Church
“Before CRISPR, homologous recombination and single-stranded DNA annealing proteins (SSAPs) enabled early gene editing, but what comes next? Deaminases, transposonases, and more sophisticated SSAPs are able to deliver gene therapies with more precision than CRISPR.”
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Science Digest
Wrench in the CRISPR method? CRISPR corrected a defective gene but introduced hundreds of new mutations to genome.
“Several preclinical trials have shown that CRISPR can correct faulty genes that cause devastating diseases such as muscular dystrophy to blindness. The CRISPR/Cas9 genetic engineering technique has now entered the clinical arena with a few clinical trials in humans in-progress and on the horizon.”
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Episode
Dr. George Church: Rewriting Genomes to Eradicate Disease and Aging
“The knowledge gained from the Project has given rise to many new therapies, including the now-famous CRISPR-Cas9, "CRISPR" for short, a powerful gene-editing technology that allows scientists to tweak a single disease-causing gene, essentially nipping the disease in the bud.”
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Dr. Aubrey de Grey and Dr. Rhonda Patrick Talk Aging
“Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS Research Foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. Learn more about Dr. Aubrey De Grey SENS Research Foundation.”
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Science Digest
Scientists record videos in strands of DNA using CRISPR gene engineering technology.
“Because the CRISPR system adds DNA snippets sequentially, the position of each snippet in the array could be used to determine the original frame to which the snippet belonged. Being able to store information (other than genetic) in DNA is kinda crazy!”
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Science Digest
Intellectual ownership of CRISPR genome editing system, hailed as one of the most important biotech development in last 40 years, is in contention.
“Read more about CRISPR here, since it's awesome.”
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Science Digest
Muscular dystrophy cured with CRISPR gene therapy which replaced dysfunctional genes in all muscles in adult mice.
“The breakthrough here is that the CRISPR/AAV was able to reach all muscles, including in the heart, after being injected into an adult mouse's bloodstream. Duchenne muscular dystrophy affects 1 in 5,000 males and most are wheelchair-bound by age 10 and don't live beyond their 20s or early 30s.”
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Science Digest
CRISPR gene editing successfully stopped the progression of Duchenne muscular dystrophy in dogs. It restored muscle function in their hearts & more.
“CRISPR gene editing successfully stopped the progression of Duchenne muscular dystrophy in dogs. It restored muscle function in their hearts, diaphragms and other muscles. Duchenne muscular dystrophy is caused by a mutation in a gene called dystrophin, which is critical for muscle function.”
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How to make cells permanently immune to all viruses │ Dr. George Church
“Dr. Church and colleagues demonstrated in a second 2022 publication that CRISPR germline editing could be used to eliminate African Swine Fever virus in pigs. In this clip, Dr. George Church discusses these findings and what they could mean for the future of public health.”
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