Episodes

What causes Alzheimer's disease? | Dale Bredesen & Rhonda Patrick

Posted on July 12th 2019 (almost 5 years)
Views: 2008

Dr. Dale Bredesen identifies the defining characteristics of Alzheimer’s disease and enumerates its known subtypes.

How long does it take for glucoraphanin to convert to sulforaphane? | Jed Fahey

Posted on January 27th 2020 (over 4 years)
Views: 2007

Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and the time frame required for full conversion.

Can caloric restriction supplements mimic fasting? | Dr. Mark Mattson

Posted on April 2nd 2022 (about 2 years)
Views: 2004

In this clip, Dr. Mark Mattson discusses the pros and cons of calorie restriction mimetics.

IGF-1 plays a key role in the regenerative processes activated by prolonged fasting | Valter Longo

Posted on July 15th 2019 (almost 5 years)
Views: 1996

Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.

Is the liver stressed when on a ketogenic diet? | Eric Verdin

Posted on July 15th 2019 (almost 5 years)
Views: 1980

Dr. Eric Verdin describes the liver's functions and proposes that the ketogenic diet does not put any undue stress on the liver.

How do shift work, jet lag, and modern lifestyles disrupt circadian rhythms? | Dr. Satchin Panda

Posted on July 27th 2021 (almost 3 years)
Views: 1973

In this clip, Dr. Satchin Panda describes how shift work and modern lifestyles affect circadian rhythms and damage metabolic health and discusses approaches that might benefit those who work shifts.

Weight loss and reversing metabolic syndrome may slow epigenetic aging | Steve Horvath

Posted on January 1st 2021 (over 3 years)
Views: 1969

In this clip, Dr. Steve Horvath describes research suggesting that caloric restriction, especially when it is reversing obesity or metabolic syndrome, may slow epigenetic aging.

Mendelian randomization, a powerful tool to assess the effects of low vitamin D | Roger Seheult

Posted on March 10th 2021 (about 3 years)
Views: 1954

In this clip, Dr. Rhonda Patrick describes what Mendelian randomization studies are and how they are valuable instruments in the scientific toolbox.

Creating cognitively challenging movement benefits brain circuits in Parkinson's disease

Posted on October 28th 2020 (over 3 years)
Views: 1934

In this clip, Dr. Giselle Petzinger discusses how adding a cognitive load to an exercise program is important for people with Parkinson's disease.

APOE4 Alzheimer's blood-brain barrier leaks — could they be even more important than amyloid? | Axel Montagne Ph.D.

Posted on March 25th 2023 (about 1 year)
Views: 1938

In this clip, Dr. Axel Montagne discusses the importance of maintaining the blood-brain barrier's integrity, especially for people with the APOE4 gene who have a higher risk of developing Alzheimer's disease.

Do hormonal responses to exercise predict gain? | Dr. Stuart Phillips

Posted on July 10th 2022 (almost 2 years)
Views: 1924

In this clip, Dr. Stuart Phillips discusses the implications of hormones in muscle mass growth and compares physiological to supraphysiological doses.

What is aging and why does it matter to scientists? | Dr. Morgan Levine

Posted on May 21st 2022 (almost 2 years)
Views: 1920

In this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists.

Sulforaphane and benzene detoxification (relevance in smokers and for air pollution) | Jed Fahey

Posted on January 30th 2020 (over 4 years)
Views: 1907

Dr. Jed Fahey describes a study that demonstrated sulforaphane's chemoprotective qualities against benzene exposure.

Does leaky gut contribute to cancer and heart disease? | Dr. Eran Elinav

Posted on February 21st 2022 (about 2 years)
Views: 1898

In this clip, Dr. Eran Elinav discusses the intestinal barrier's important role in absorbing nutrients while keeping out pathogens.

Psychedelic drugs, psilocybin, and transcendent experiences as antidepressants | Charles Raison

Posted on August 27th 2019 (over 4 years)
Views: 1869

Dr. Charles Raison discusses how psychedelic substances like psilocybin, which induce transcendent trance-like states may be useful in the treatment of depression.

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