Episode archive
Dr. Rhonda Patrick explains how intermittent fasting shifts fuel use and discusses visceral fat, cognition, fasted exercise, and under-fueling.
Dr. Rhonda Patrick explains urolithin A, mitophagy, muscle function, dosing, food timing, and continuous use.
Dr. Derya Unutmaz explains how AI may help clinicians reduce diagnostic errors, interpret complex data, and monitor treatment over time.
Dr. Rhonda Patrick reviews multivitamins for cognitive aging and creatine for muscle energy and cognitive performance during sleep loss.
Dr. Rhonda Patrick explains how late meals interact with melatonin, glucose control, sleep, and nighttime blood-pressure dipping.
Dr. Rhonda Patrick compares caffeinated and decaf coffee for alertness, Parkinson's associations, diabetes, and DNA strand-break markers.
Dr. Rhonda Patrick explains how oat beta-glucan lowers LDL and explores PFAS levels, gut fermentation, and supplement quality.
Dr. Rhonda Patrick discusses how sleep, nutrients, BPA, phthalates, and PFAS may affect testosterone and endocrine health.
Dr. Rhonda Patrick compares vigorous and moderate exercise and explains how VO₂ max, interval walking, and resistance training support healthy aging.
Dr. Rhonda Patrick explains how magnesium supports energy metabolism and DNA repair, and compares food sources with organic and oxide supplements.
Dr. Derya Unutmaz explains how immunotherapy, targeted drugs, CAR-T cells, personalized mRNA vaccines, and AI may reshape cancer treatment.
Dr. Derya Unutmaz explains longevity escape velocity and how AI, cancer treatments, GLP-1 drugs, and regenerative medicine may extend healthy life.
Dr. Rhonda Patrick compares organic and conventional produce for nutrients, pesticide exposure, and oxidative-stress biomarkers.
Dr. Rhonda Patrick links morning light, regular wake times, earlier meals, and less bedtime alcohol with circadian timing and sleep quality.
Dr. Rhonda Patrick compares daily steps with vigorous activity and explains how both support cardiovascular and metabolic health.
Dr. Rhonda Patrick explains creatine for muscle energy and explores brain dosing and cognitive performance during sleep loss.
Dr. Rhonda Patrick reviews omega-3, multivitamins, vitamin D, magnesium, and creatine for nutrient gaps, exercise, and brain energy.
Dr. Rhonda Patrick explains how sleep loss impairs insulin sensitivity and how vigorous exercise supports muscle glucose uptake through GLUT4.
Dr. Rhonda Patrick describes brief vigorous lifestyle activity, including stairs and squats, and reports mortality associations in non-exercisers.
Dr. Rhonda Patrick explains how sleep, meal order, and individual food responses shape CGM glucose readings and relate to brain health.
Dr. Rhonda Patrick explains how aerobic exercise, resistance training, calorie balance, and sleep can affect visceral fat.
Dr. Rhonda Patrick explains how kale, blueberries, avocado, protein, and beta-glucan shape her smoothie's nutrients, fiber, and carotenoid absorption.
Dr. Rhonda Patrick compares 10,000 steps with brief vigorous exercise snacks for cardiovascular fitness, glucose control, and muscle stimulus.
Dr. Rhonda Patrick reports that two years of progressive endurance training, including Norwegian 4×4 intervals, improved VO₂ max and heart stiffness.
Dr. Rhonda Patrick reviews how multivitamins, vitamin D, omega-3s, and magnesium address cognitive, cardiovascular, and micronutrient needs.
Dr. Rhonda Patrick explains how fiber supports gut microbes and colon health and discusses whole fruit, produce, and pesticide exposure.
Dr. Rhonda Patrick discusses ubiquinol and mitochondrial function, sulforaphane and NRF2 signaling, and urolithin A and mitophagy.
Dr. Steve Horvath discusses blood carotenoids, vegetable intake, exercise, and their associations with epigenetic aging.
Dr. Rhonda Patrick compares beta-glucan and psyllium for LDL and reviews early human research on serum PFAS.
Dr. Rhonda Patrick and Dr. Steve Horvath discuss COSMOS multivitamin findings for cognition and epigenetic aging in older adults.
Dr. Rhonda Patrick and Dr. Steve Horvath discuss DO-HEALTH findings on omega-3, vitamin D, strength exercise, and aging clocks.
Dr. Rhonda Patrick explains how exercise snacks break up sitting, support glucose control, and add vigorous activity through VILPA.
Dr. Rhonda Patrick and Dr. Andrew Huberman discuss processed meals, gut-derived LPS, fatigue, mood, and apoB-driven vascular inflammation.
Dr. Rhonda Patrick explains creatine dosing for muscle performance and explores brain energy and cognition during severe sleep deprivation.
Dr. Rhonda Patrick explains how exercise, energy balance, sleep, menopause, and time-restricted eating relate to visceral fat.
Kelly Starrett explains simple tests for hip flexion and extension, from the sit-and-rise test to the couch stretch.
Dr. Rhonda Patrick explains how two years of aerobic exercise, Norwegian 4x4 intervals, and strength training raised VO2 max and reduced cardiac stiffness.
Dr. Rhonda Patrick explains why vigorous activity can deliver greater health benefits per minute than moderate exercise.
Dr. Rhonda Patrick discusses early-onset cancer trends and how weight, alcohol, processed meat, inactivity, and low-fiber diets may contribute.
Dr. Arthur Brooks shares a five-part morning routine combining exercise, spiritual practice, creatine, caffeine, and protein for deep work.
Dr. Rhonda Patrick discusses blueberries and cognition, plant fiber and polyphenols, and how banana PPO can affect flavan-3-ol absorption.
Dr. Rhonda Patrick explains how zinc, vitamin D, magnesium, and dietary fat relate to testosterone and nutrient status.
Dr. Rhonda Patrick explains how glutamine fuels gut and immune cells and reviews early human evidence during heavy physical stress.
Dr. Rhonda Patrick explains how water filtration, safer food contact, and indoor air control can reduce microplastic exposure.
Dr. Rhonda Patrick and Dr. Kelly Starrett discuss VILPA, movement snacks, glucose control, fitness, and varied daily activity.
Dr. Rhonda Patrick explains how EPA and DHA support inflammation resolution and discusses aging clocks, triglycerides, and cardiovascular evidence.
Dr. Kelly Starrett explains how supported floor transfers train strength, balance, coordination, flexibility, and movement confidence.
Dr. Rhonda Patrick explains creatine loading and maintenance for muscle and explores cognition and brain energy during severe sleep loss.
Dr. Rhonda Patrick explains how exercise, energy balance, sleep, and time-restricted eating relate to visceral fat and insulin sensitivity.
Dr. Rhonda Patrick explains how omega-3 dose and formulation relate to cardiovascular outcomes, the Omega-3 Index, and DNA-methylation aging clocks.
Dr. Rhonda Patrick explains how alcohol relates to visceral fat and affects liver metabolism and gut-barrier function, then discusses phones and sleep.
Dr. Rhonda Patrick reviews curcumin, urolithin A, and glutamine for inflammation, mitochondria, immunity, and exercise.
Dr. Rhonda Patrick explains how sleep-aligned overnight fasting affects nighttime blood-pressure dipping and evening glucose control.
Dr. Rhonda Patrick explains how two years of progressive exercise increased VO2 max and cardiac filling and reduced heart stiffness in sedentary adults.
Dr. Rhonda Patrick explains peakspan and how exercise, sleep, learning, and resistance training may preserve function with age.
Dr. Rhonda Patrick explains how VILPA and movement breaks complement structured exercise and support glucose control and cardiorespiratory fitness.
Dr. Rhonda Patrick explains how to match glutathione, vitamins, omega-3, creatine, and magnesium to individual needs.
Dr. Rhonda Patrick explains how exercise may support glucose handling after sleep loss and why intensity should match alertness and recovery.
Dr. Rhonda Patrick explains creatine for training and explores brain energy, cognition during severe sleep loss, and product quality.
Dr. Rhonda Patrick explains how kitchen materials, heat, abrasion, cookware, receipts, and water filters shape everyday chemical exposure.
Dr. Rhonda Patrick reviews multivitamins, CoQ10, urolithin A, and sulforaphane for cognitive and cellular health.
Dr. Rhonda Patrick reviews a post hoc analysis of a three-year omega-3 trial that found small changes in selected epigenetic aging clocks in older adults.
Dr. Rhonda Patrick explains why visceral fat can affect metabolic health even in people who appear lean.
Dr. Rhonda Patrick reviews COSMOS multivitamin findings for cognition in older adults and discusses nutrient gaps, product quality, and iron needs.
Dr. Rhonda Patrick discusses brief exercise, fasting, exogenous ketones, cold exposure, and passive heating for focus, alertness, and sleep.
Dr. Arthur Brooks shares healthy-aging themes involving activity, learning, coping skills, and close relationships.
Dr. Rhonda Patrick explains how omega-3 status, dose, formulation, and individual risk shape potential benefits.
Dr. Rhonda Patrick explains how brief vigorous exercise can support acute cognition and how regular aerobic activity relates to mortality and brain health.
Dr. Rhonda Patrick explains how exercise and meal composition can shape inflammation, post-meal metabolism, and brain fog.
Dr. Rhonda Patrick compares soluble fiber, omega-3, garlic, berberine, red yeast rice, and niacin for cholesterol and triglycerides.
Dr. Rhonda Patrick discusses resistance and weight-bearing exercise, calcium, vitamin D, creatine, and collagen for bone health after 65.
Dr. Rhonda Patrick compares aerobic exercise, HIIT, and resistance training for reducing visceral fat and supporting metabolic health.
Dr. Rhonda Patrick reviews a five-day snack-overfeeding study that changed liver fat and brain insulin response without increasing visceral fat.
Dr. Rhonda Patrick explains how vigorous activity relates to cancer risk and how exercise can support people during and after cancer treatment.
Dr. Rhonda Patrick discusses food-first calcium and iron, vitamin D, omega-3, multivitamins, creatine, and protein powder for children.
Dr. Rhonda Patrick explains how glucose temporarily affects testosterone testing and reviews human research on BPA and phthalates.
Dr. Rhonda Patrick reviews COSMOS multivitamin findings and discusses how omega-3, magnesium, and vitamin D needs vary among older adults.
Dr. Charles Brenner explains how nicotinamide riboside raises NAD metabolites and what human studies show about exercise recovery.
Dr. Rhonda Patrick explains how creatine supports training and brain energy and reviews high-dose research during sleep loss.
Dr. Rhonda Patrick explains how purpose, mortality reflection, and close relationships can clarify what matters most.
Dr. Rhonda Patrick explains cold exposure for focus, mood, brown fat, and endurance, plus why timing matters after strength training.
Dr. Rhonda Patrick explains how two years of progressive exercise improved VO2 max, heart filling, and cardiac flexibility.
Dr. Rhonda Patrick explains how meals, consistency, and individual goals shape the timing of vitamin D, omega-3s, magnesium, and more.
Dr. Rhonda Patrick explains why consistency matters more than the clock while comparing morning and evening exercise.
Dr. Charles Brenner explains how nicotinamide riboside raises NAD and compares oral NR with NAD, NMN, and intravenous delivery.
Dr. Rhonda Patrick examines hydrogen-rich water for inflammation, oxidative stress, lipids, and exercise recovery.
Dr. Rhonda Patrick discusses creatine dosing for muscle and brain energy, cognition, sleep loss, and methylation.
Dr. Rhonda Patrick details how sulforaphane supports glutathione, NRF2 signaling, and pollutant detoxification.
Dr. Rhonda Patrick reviews vitamin D, omega-3s, multivitamins, magnesium, creatine, and melatonin for adults over 65.
Dr. Rhonda Patrick explores sauna use, cardiovascular fitness, blood pressure, mortality associations, and practical heat exposure.
Dr. Rhonda Patrick compares interval protocols for improving VO2 max and describes how sustained training can reshape heart function.
Dr. Rhonda Patrick demonstrates exercise snacks and discusses VILPA, mortality associations, and glucose control.
Dr. Rhonda Patrick shares how she combines exercise, protein, creatine, omega-3s, magnesium, and heat in her weekly routine.
Dr. Rhonda Patrick reviews how body weight, exercise, diet, and selected supplements relate to osteoarthritis prevention and symptoms.
Dr. Rhonda Patrick details how vigorous exercise and Norwegian 4x4 intervals can raise VO2 max and improve cardiac fitness.
Dr. Ben Bikman and Dr. Rhonda Patrick discuss fasting insulin, triglyceride-to-HDL ratio, uric acid, ApoB, and metabolic aging.
Dr. Rhonda Patrick reviews a preliminary study of melatonin use and heart failure alongside randomized evidence and study design.
Dr. Rhonda Patrick compares low omega-3 status with smoking and explains how the Omega-3 Index reflects long-term intake.
Dr. Rhonda Patrick explores how exercise-derived lactate may fuel the brain, raise BDNF, and support cognition.
Dr. Rhonda Patrick examines how vitamin D status relates to gene regulation, epigenetic aging, cognition, and dementia risk.
Dr. Rhonda Patrick explains how vigorous exercise, VO2 max, and Norwegian 4x4 intervals relate to heart fitness and aging.
Dr. Rhonda Patrick details how sulforaphane activates NRF2 and discusses food sources, pollutant excretion, DNA damage, and supplements.
Dr. Rhonda Patrick explains how banana polyphenol oxidase can reduce flavanol absorption in smoothies and why avocado is one alternative.
Dr. Rhonda Patrick reviews the Omega-3 Index, cardiovascular research, lifespan associations, and practical EPA and DHA dosing.
Dr. Rhonda Patrick and Brady Holmer discuss vigorous exercise, glucose transport, lactate signaling, and mitochondrial adaptation.
Dr. Rhonda Patrick and Thomas DeLauer discuss why breakfast, protein distribution, and earlier eating windows can support metabolic health.
Dr. Rhonda Patrick explains how hot paper cups, tea bags, bottle caps, and can linings can add microplastics and plastic chemicals.
Dr. Rhonda Patrick and Brady Holmer detail how vigorous exercise supports VO2 max, fast-twitch fibers, and resilience with age.
Dr. Rhonda Patrick and Brady Holmer describe how brief vigorous activity can add up across the day and support long-term health.
Dr. Rhonda Patrick and Brady Holmer examine how exercise-driven shear stress supports artery function and may damage circulating tumor cells.
Dr. Rhonda Patrick and Brady Holmer compare health-equivalence ratios for vigorous, moderate, and light physical activity.
Dr. Andy Galpin compares HRV, resting heart rate, and respiratory rate as practical markers of recovery and stress.
Dr. Rhonda Patrick reviews sleep, hydration, exercise, diet, and selected nutrients that may reduce migraine frequency and severity.
Dr. Rhonda Patrick and Chris Williamson discuss plastic exposure from water, food packaging, tea bags, black utensils, and receipts.
Dr. Michael Grandner explains how predictable routines, morning light, and dimmer evenings help support sleep timing.
Dr. Rhonda Patrick and Dr. Peter Attia compare protein needs for older adults and how higher intake may preserve muscle and reduce frailty.
Dr. Rhonda Patrick and Dr. Peter Attia discuss sauna temperature, heat shock proteins, and observational research on dementia risk.
Dr. Rhonda Patrick examines how sleep loss disrupts glucose control and how high-intensity interval training may help.
Dr. Rhonda Patrick explains how inactivity reduces cardiorespiratory fitness and how vigorous exercise can help preserve it with age.
Dr. Rhonda Patrick reviews multivitamins for cognitive aging and sulforaphane for DNA protection and detoxification.
Dr. Rhonda Patrick and Steven Bartlett explore ketosis, metabolic flexibility, weight loss, and ketones as brain fuel.
Dr. Rhonda Patrick and Dr. Peter Attia discuss creatine dosing, cognition under stress, product quality, and muscle performance.
Dr. Rhonda Patrick details how vigorous exercise raises VO2 max and can restore flexibility to an aging heart.
Dr. Peter Attia and Dr. Rhonda Patrick discuss why 1.6 grams of protein per kilogram supports muscle gains and when more may help.
Dr. Michael Grandner outlines how sleep apnea stresses the brain and body and reviews treatment options beyond CPAP.
Dr. Rhonda Patrick and Dr. Peter Attia explain how protein and resistance training work together to protect muscle and function with age.
Dr. Rhonda Patrick reviews how exercise, sleep, stress management, diet, and key nutrients can support immune function with age.
Dr. Rhonda Patrick compares vigorous exercise with Zone 2 and explains why higher intensity may deliver more benefit per minute.
Dr. Rhonda Patrick examines how exercise may lower cancer risk and support treatment, recovery, and long-term survival.
Dr. Rhonda Patrick explains how vigorous intervals can raise VO2 max and how sustained training can reduce cardiac stiffness.
Dr. Michael Grandner outlines why THC and alcohol can promote sleep at first yet disrupt sleep architecture or trigger rebound wakefulness.
Dr. Rhonda Patrick examines how vitamin D status relates to dementia risk and why blood testing can guide supplementation.
Derek from MPMD compares testosterone delivery methods and explains how route, frequency, and monitoring shape treatment.
Dr. Rhonda Patrick details how the Omega-3 Index, supplement form, dose, and testing can guide EPA and DHA intake.
Dr. Michael Grandner explains how stimulus control rebuilds the bed-sleep association and reduces effort-driven wakefulness.
Dr. Michael Grandner compares melatonin, magnesium, glycine, and other supplements for sleep support and timing.
Dr. Rhonda Patrick reviews observational research on prenatal acetaminophen use and neurodevelopmental outcomes.
Dr. Rhonda Patrick explores how brief vigorous exercise snacks can interrupt sitting and support glucose control.
Dr. Rhonda Patrick describes vigorous interval protocols that improve VO2 max and reduce cardiac stiffness in midlife.
Dr. Rhonda Patrick discusses how coffee compounds, dose, and brewing method relate to mortality and cardiometabolic health.
Derek reviews how minoxidil, antiandrogens, ketoconazole, and microneedling are used to treat pattern hair loss.
Dr. Rhonda Patrick explains why vitamin D blood levels vary with metabolism, sun exposure, absorption, and supplementation.
Dr. Rhonda Patrick compares sauna types and describes a small study of whole-body hyperthermia plus CBT for depression.
Dr. Rhonda Patrick explains how creatine supports high-intensity exercise and reviews a small sleep-deprivation study.
Derek discusses obesity, weight loss, and other lifestyle factors that may influence testosterone physiology.
Dr. Ben Bikman explains how dynamic glucose responses and two skin findings can signal possible insulin resistance before diagnosis.
Derek reviews how nutrient status and selected supplements may influence testosterone, with effects that vary by baseline status.
Dr. Rhonda Patrick discusses how vigorous intervals can improve VO2 max and how a two-year program changed heart stiffness.
Dr. Rhonda Patrick explores why exercise intensity and lactate signaling add benefits that step counts alone do not capture.
Dr. Rhonda Patrick shares sleep strategies involving light, timing, temperature, routines, and carefully selected supplements.
Dr. Rhonda Patrick examines how magnesium supports energy and DNA repair and how low intake is associated with health risks.
Drs. Ben Bikman and Rhonda Patrick discuss how breakfast composition and meal timing affect glucose, insulin, appetite, and metabolic health.
Dr. Rhonda Patrick explains how exercise, fitness, sleep, APOE4, and multivitamins relate to memory and healthy brain aging.
Dr. Rhonda Patrick discusses leafy greens, blueberries, and omega-3s for micronutrients, cognition, mood, and healthy aging.
Dr. Rhonda Patrick and Tim Ferriss discuss practical ways to reduce microplastic exposure from water, tea bags, cups, bottles, and gum.
Drs. Ben Bikman and Rhonda Patrick explain how late meals, sleep loss, and morning caffeine can affect glucose regulation and metabolism.
Dr. Rhonda Patrick explains how creatine supports muscle and brain energy and reviews high-dose research during acute sleep deprivation.
Dr. Rhonda Patrick reviews multivitamins, vitamin D, omega-3s, ubiquinol, and sulforaphane in the context of her parents’ health.
Dr. Rhonda Patrick and Mayim Bialik discuss exercise for depression, acute BDNF responses, and practical ways to raise intensity.
Dr. Rhonda Patrick explains how VO2 max, the Cooper test, vigorous intervals, and progressive training support heart health.
Dr. Ben Bikman and Dr. Rhonda Patrick discuss how berberine, vinegar, and ketones influence glucose regulation and metabolic signaling.
Dr. Rhonda Patrick discusses the observed link between golf course proximity, water vulnerability, and Parkinson's disease.
Dr. Rhonda Patrick reviews how coffee relates to cancer risk, DNA strand breaks, and the gut microbiome.
Dr. Rhonda Patrick explains how gaps in vitamin C, choline, vitamin E, and vitamin K may affect long-term health and aging.
Dr. Rhonda Patrick reviews observational evidence linking frequent sauna use with lower dementia and Alzheimer's disease incidence.
Drs. Ben Bikman and Rhonda Patrick discuss how GLP-1 drugs affect appetite, weight loss, lean mass, and safety.
Dr. Rhonda Patrick reviews vitamin D, omega-3s, multivitamins, magnesium, and choline for common nutrient gaps.
Drs. Ben Bikman and Rhonda Patrick explain how diet, post-meal activity, eggs, and vinegar can influence blood glucose.
Dr. Rhonda Patrick explains creatine's muscle and brain effects, including evidence in vegetarians and during acute sleep loss.
Dr. Rhonda Patrick explains how milk, MCTs, and L-theanine may change coffee's polyphenol absorption, cognition, and side effects.
Dr. Rhonda Patrick explains how chronic high glucose affects cardiovascular tissue and how exercise improves glucose handling.
Dr. Rhonda Patrick examines omega-3 status, mortality, dose response, and emerging evidence for preserving muscle during disuse.
Drs. Rhonda Patrick and Mark Hyman discuss how an ultra-processed diet can increase calorie intake and short-term weight gain.
Dr. Rhonda Patrick reviews vitamin D status, common insufficiency, dementia associations, and why supplementation should be individualized.
Dr. Rhonda Patrick compares filtered, unfiltered, espresso, and instant coffee for diterpenes, cholesterol, and longevity associations.
Dr. Rhonda Patrick details her supplement routine, including omega-3s, creatine, melatonin, magnesium, and product-selection criteria.
Dr. Rhonda Patrick explains how vigorous exercise produces lactate and how lactate may support brain energy, BDNF, and adaptation.
Dr. Rhonda Patrick discusses lead findings in greens powders and explains why product-specific independent testing matters.
Dr. Andy Galpin explains how beta-alanine raises muscle carnosine, delays fatigue, and differs from sodium bicarbonate.
Dr. Rhonda Patrick reviews coffee timing, mortality, cardiovascular health, diabetes, and possible epigenetic pathways.
Dr. Rhonda Patrick discusses cold exposure, norepinephrine, mood and focus, and why timing matters after resistance training.
Dr. Rhonda Patrick explains why Norwegian 4x4 intervals are a powerful way to improve VO2 max and cardiorespiratory fitness.
Dr. Rhonda Patrick describes how sauna frequency relates to dementia risk, vascular health, sleep, and heat adaptation.
Drs. Rhonda Patrick and Mark Hyman discuss multivitamins, vitamin D, potassium, and omega-3s for brain and metabolic health.
Dr. Rhonda Patrick reviews how exercise snacks and brief vigorous activity improve glucose control and support longevity.
Dr. Andy Galpin discusses how ventilation, nasal breathing, and bedroom conditions influence sleep quality.
Dr. Rhonda Patrick explains how vigorous exercise can improve glucose handling and mental sharpness after insufficient sleep.
Dr. Rhonda Patrick outlines cancer-risk habits involving tobacco, body composition, activity, diet, alcohol, and vitamin D.
Dr. Rhonda Patrick breaks down how food order, exercise snacks, smaller meals, and omega-3s may support mental clarity after eating.
Drs. Darren Candow and Rhonda Patrick discuss emerging evidence that creatine may support sleep and brain health after training.
Dr. Rhonda Patrick separates evidence on fiber, PFAS, sweat, sulforaphane, and clean-air measures for environmental exposures.
Dr. Rhonda Patrick explains why omega-3, vitamin D, and sulforaphane lead her short list of essential supplements.
Dr. Rhonda Patrick explains how protein, resistance training, and earlier meal timing can make time-restricted eating more practical.
Drs. Andy Galpin and Rhonda Patrick discuss glutamine as fuel for immune and gut cells and explain how they use it in practice.
Dr. Rhonda Patrick explains why cardiorespiratory fitness and brief vigorous exercise can matter more than a fixed daily step target.
Dr. Rhonda Patrick outlines how vigorous exercise, micronutrients, berries, and omega-3s can support memory and cognitive function.
Dr. Andy Galpin compares beetroot, citrulline, and arginine for nitric oxide support, exercise performance, timing, and tolerability.
Drs. Rhonda Patrick and Mark Hyman explain how the Omega-3 Index relates to longevity, seafood intake, and cardiovascular health.
Drs. Darren Candow and Rhonda Patrick examine creatine myths about hair loss, blood pressure, sleep, cancer, and urination.
Drs. Rhonda Patrick and Mark Hyman discuss vitamin D, omega-3s, multivitamins, magnesium, and sulforaphane for nutrient coverage.
Dr. Rhonda Patrick explains how progressive aerobic training and intervals can improve cardiac stiffness, VO2 max, and mitochondria.
Dr. Rhonda Patrick explains how ultra-processed foods can increase calorie intake, weaken satiety, and promote weight gain.
Drs. Rhonda Patrick and Darren Candow discuss creatine dosing for brain energy, aging, sleep loss, and mental fatigue.
Dr. Rhonda Patrick explains how sustained blood sugar exposure can affect brain structure, inflammation, and cardiovascular stiffness.
Drs. Rhonda Patrick and Darren Candow explain how creatine supports strength, training capacity, recovery, and muscle adaptation.
Drs. Rhonda Patrick and Darren Candow explain why one lean-mass trial does not overturn the broader creatine evidence.
Dr. Rhonda Patrick explains how aerobic exercise, lactate, and BDNF support hippocampal volume, learning, and memory.
Dr. Rhonda Patrick discusses an acute glucose-related testosterone drop and associations between added sugar and reward signaling.
Dr. Rhonda Patrick outlines practical ways to reduce microplastic exposure from water, food packaging, heat, friction, and receipts.
Dr. Rhonda Patrick explains how exercise supports diabetes prevention, blood pressure control, and depressive symptoms.
Dr. Rhonda Patrick explains glucose disposal, heart flexibility, and a short sleep-restriction exercise study.
Dr. Rhonda Patrick and Brady Holmer explain how omega-3s and creatine support muscle preservation, training, and recovery.
Dr. Rhonda Patrick discusses zinc lozenges, vitamin C, and glutamine as targeted tools for cold symptoms and immune support.
Dr. Kerry Courneya and Dr. Rhonda Patrick discuss smoking, weight, alcohol, and exercise as modifiable influences on cancer risk.
Dr. Kerry Courneya explains to Dr. Rhonda Patrick how exercise may support tumor perfusion, immune surveillance, and treatment response.
Dr. Rhonda Patrick describes why she prioritizes omega-3s, vitamin D, a multivitamin, sulforaphane, and magnesium.
Dr. Rhonda Patrick explains how low-dose nicotine can affect attention while also creating dependence, cardiovascular, and sleep risks.
Dr. Rhonda Patrick and Brady Holmer explain how brief exercise snacks can support fitness, glucose control, focus, and longevity.
Dr. Rhonda Patrick and Brady Holmer discuss how post-exercise sauna use may support fitness, blood pressure, recovery, and muscle.
Dr. Rhonda Patrick and Brady Holmer compare the Norwegian 4x4, 10x1, and Tabata formats for improving VO2 max.
Dr. Rhonda Patrick and Brady Holmer explain how a progressive two-year program improved fitness and reduced cardiac stiffness.
Dr. Rhonda Patrick and Brady Holmer explain how heart rate, perceived exertion, and the talk test can guide cardio intensity.
Dr. Rhonda Patrick and Brady Holmer discuss how lifelong aerobic exercise frequency relates to cardiac structure and healthy aging.
Dr. Rhonda Patrick reviews berberine research on inflammation, blood lipids, atherosclerosis markers, and medication interactions.
Dr. Rhonda Patrick explains how sauna timing, cooling, and short-lived hormone responses may support an evening sleep routine.
Dr. Rhonda Patrick explains alpha-lipoic acid as a mitochondrial cofactor and reviews its effects on lipids, glucose, and oxidative stress.
Dr. Stuart Phillips and Dr. Rhonda Patrick discuss creatine monohydrate for strength, muscle, cognition, and healthy aging.
Dr. Peter Attia and Dr. Rhonda Patrick discuss vitamin D status, supplementation, deficiency, and uncertainty about higher targets.
Dr. Rhonda Patrick reviews human evidence linking BPA and microplastic exposure with selected reproductive and semen outcomes.
Dr. Rhonda Patrick explains ApoB, omega-3 supplementation, and how dietary fat patterns can affect atherogenic lipoproteins.
Dr. Rhonda Patrick reviews cocoa flavanol studies on walking, cognition, skin, dosing, caffeine, and product quality.
Dr. Rhonda Patrick explains practical ways to reduce particles and plastic-associated chemicals in water, food, clothing, and cookware.
Dr. Rhonda Patrick describes her serum, retinol, salicylic-acid, and occasional vitamin C routine with formulation limits.
Dr. Rhonda Patrick reviews diet, antioxidants, alcohol, body weight, exercise, and heat exposure in male fertility.
Dr. Rhonda Patrick describes her weekly mix of strength circuits, heavy compound lifts, zone 2 runs, Tabata rides, and sauna.
Dr. Rhonda Patrick explains how a brief aerobic workout before learning or several hours afterward can support later memory recall.
Dr. Rhonda Patrick explains goal-weight protein targets, recomposition, satiety, athlete intake, and kidney-safety limits.
Dr. Rhonda Patrick discusses sauna, sulforaphane, time-restricted eating, and recoverable high-intensity exercise.
Dr. Rhonda Patrick explores stress, nutrient status, mitochondria, and red light as possible factors in selected cases of hair repigmentation.
Dr. Rhonda Patrick summarizes eight protein lessons on targets, meals, timing, supplements, quality, kidneys, and longevity.
Dr. Rhonda Patrick explains muscle reserve, insulin sensitivity, frailty risks, and how strength remains trainable with age.
Dr. Rhonda Patrick examines grounding claims and explains why stronger trials and objective biomarkers are needed to assess inflammation effects.
Dr. Rhonda Patrick shares how she organizes three daily meals, an early eating window, protein, vegetables, fruit, and fermented foods.
Dr. Rhonda Patrick explains how protein, resistance training, omega-3s, and heat may help preserve muscle mass.
Dr. Rhonda Patrick reviews alpha-lipoic acid research on insulin sensitivity, diabetic neuropathy, redox biology, and brain aging.
Dr. Rhonda Patrick explains how distinct sleep-loss patterns affect glucose control, HbA1c, appetite, and vascular aging.
Dr. Rhonda Patrick outlines blood biomarkers and discusses evidence-limited microbiome and gut-permeability testing.
Dr. Rhonda Patrick weighs egg nutrients, lipid responses, and conflicting observational cardiovascular evidence against intervention data.
Dr. Rhonda Patrick explains how sodium affects blood pressure and why individual needs vary with health, diet, exercise, and sweat loss.
Dr. Rhonda Patrick walks through her October 2024 supplement routine, including omega-3s, creatine, magnesium, collagen, and zinc lozenges.
Dr. Rhonda Patrick explains how banana polyphenol oxidase can reduce flavanol availability in berry and cocoa smoothies.
Dr. Rhonda Patrick and Dr. Layne Norton discuss how a short food log can clarify energy intake, portion size, and a starting point for weight loss.
Dr. Rhonda Patrick separates microplastic particles from plastic-associated chemicals and explains practical exposure-reduction steps.
Dr. Rhonda Patrick explains how HIIT may counter some metabolic effects of unavoidable sleep loss without replacing adequate sleep.
Dr. Rhonda Patrick explains how fermented foods, diverse fibers, organic acids, probiotics, and glutamine fit different gut contexts.
Dr. Rhonda Patrick outlines how light, caffeine timing, sleep extension, and multicomponent CBT-I can support better sleep.
Dr. Rhonda Patrick explains how brief exercise snacks support post-meal glucose control and relate to lower mortality risk.
Dr. Rhonda Patrick explains HIIT protocols, recovery, glucose control, body composition, and mitochondrial adaptation.
Dr. Benjamin Levine explains why sustained endurance exercise supports blood pressure control alongside strength training and clinical care.
Dr. Rhonda Patrick and Dr. Layne Norton examine calorie intake, meal timing, autophagy, body fat, and adherence in time-restricted eating.
Dr. Rhonda Patrick reviews seven habits that may influence inflammatory pathways, with limits on disease and biomarker claims.
Dr. Peter Attia explains how a VO2 max test measures aerobic capacity, fuel use, and peak fat oxidation during graded exercise.
Dr. Rhonda Patrick separates exposure reduction from limited evidence on metabolism and excretion of plastic-associated chemicals.
Dr. Rhonda Patrick weighs the cardiovascular benefits of omega-3s against dose-related atrial fibrillation findings.
Dr. Rhonda Patrick outlines practical ways to reduce microplastic, BPA, phthalate, and PFAS exposure in daily life.
Dr. Rhonda Patrick separates preclinical BPA mechanisms, prenatal associations, and human microplastic detection from causal claims.
Dr. Rhonda Patrick examines food-additive oversight, packaging chemicals, and how ultra-processed diets can increase calorie intake.
Dr. Layne Norton and Dr. Rhonda Patrick compare diet soda with water and examine weight loss, microbiome responses, and aspartame safety.
Dr. Rhonda Patrick ranks exercise, weight loss, glycemic load, meal timing, sleep, and selected supplements for glucose control.
Dr. Layne Norton and Dr. Rhonda Patrick discuss why elimination can ease symptoms while fiber and plant foods support long-term health.
Dr. Rhonda Patrick explains exercise, cancer-survival associations, tumor-cell shear, myokines, and kynurenine metabolism.
Dr. Layne Norton compares seed oils, saturated fat, and olive oil while separating calorie load from fat-specific effects.
Dr. Layne Norton explains how proximity to failure, exercise choice, and fatigue shape muscle growth and strength training.
Dr. Layne Norton ranks creatine, rhodiola, and ashwagandha by evidence for performance, cognition, stress, and recovery.
Dr. Luc van Loon explains how protein dose, amino acids, digestibility, and processing shape muscle growth on plant-based diets.
Dr. Andrew Huberman explains how growth mindset and stress reappraisal can help the brain associate effort with progress.
Dr. Rhonda Patrick explains how vigorous exercise improves cardiac flexibility and triggers signals that support brain and metabolic health.
Dr. Rhonda Patrick explains how sunlight, body fat, magnesium, and vitamin K shape vitamin D status and supplementation.
Dr. Luc van Loon examines collagen digestion, tissue turnover, and where human evidence for collagen supplements remains limited.
Dr. Andrew Huberman and Dr. Rhonda Patrick explain how behavior, diagnosis, and medication can fit together in ADHD care.
Dr. Rhonda Patrick reviews small, conflicting human lion’s-mane studies and explains why product identity and further research matter.
Dr. Luc van Loon explains protein adaptation, goal-weight calculations, meal dose, activity, and anabolic resistance across age.
Dr. Luc van Loon explains why cold-water immersion soon after exercise can reduce muscle protein synthesis and training adaptation.
Dr. Luc van Loon explains hospital fasting, breakfast, TRE, energy restriction, exercise sensitization, and protein priorities.
Dr. Rhonda Patrick compares sauna protocols, exercise-plus-heat, heat-shock proteins, baths, mood hypotheses, and access limits.
Dr. Rhonda Patrick shares practical ways she limits plastic contact with food and water, especially during heating and storage.
Dr. Rhonda Patrick explains alcohol effects across female and male fertility, conception, ART, pregnancy, and offspring evidence.
Dr. Rhonda Patrick asks whether alcohol explains Blue Zone longevity and separates social context from noncausal drinking patterns.
Dr. Rhonda Patrick explains how alcohol can blunt repair and how exercise may affect craving and alcohol use disorder.
Dr. Andrew Huberman explains dopamine in movement, effort, digital rewards, stimulants, recovery, and post-event fatigue.
Dr. Rhonda Patrick reviews alcohol, nutrients, gut and brain inflammation, conflicting dementia cohorts, APOE4, and evidence limits.
Dr. Rhonda Patrick and Dr. Andrew Huberman discuss how visualization, discomfort, and hard exercise can help restart motivation.
Dr. Rhonda Patrick reviews hangover causes, drink type, food, hydration, nutrients, and the limited evidence behind common remedies.
Dr. Rhonda Patrick outlines lower-risk drinking choices involving dose, food, hydration, sleep, exercise, and medication safety.
Dr. Rhonda Patrick and Dr. Andrew Huberman explain how non-sleep deep rest trains relaxation and may support recovery and learning.
Dr. Rhonda Patrick and Dr. Andrew Huberman discuss how social media affects reward, attention, anxiety, relationships, and presence.
Dr. Rhonda Patrick and Dr. Andrew Huberman explain how morning outdoor light anchors circadian timing, daytime alertness, and sleep.
Dr. Rhonda Patrick and Dr. Andrew Huberman discuss how alcohol dose, metabolism, sleep, and gut effects shape brain-health risk.
Dr. Rhonda Patrick and Dr. Andrew Huberman discuss how cold stress changes catecholamines, alertness, and readiness for effort.
Dr. Andrew Huberman explains how caffeine, prescription stimulants, and nicotine change alertness, dopamine signaling, and motivation.
Dr. Andrew Huberman describes how he combines sleep, exercise, food, supplements, recovery, and flexibility in a sustainable routine.
Dr. Rhonda Patrick reviews magnesium, apigenin, L-theanine, glycine, GABA, and myo-inositol in a popular sleep stack.
Dr. Benjamin Levine explains how endurance and strength training protect cardiac function, blood vessels, and aerobic capacity with age.
Dr. Benjamin Levine explains why resting-heart-rate trends can be more actionable than uncontrolled wearable HRV readings for recovery.
Dr. Benjamin Levine outlines a weekly mix of intervals, moderate aerobic work, a longer session, recovery, and strength training.
Dr. Rhonda Patrick reviews melatonin’s antioxidant effects, exercise tradeoffs, dosing, side effects, interactions, and product quality.
Dr. Rhonda Patrick compares chemical-filter absorption with zinc oxide and titanium dioxide safety, coatings, and inhalation concerns.
Dr. Rhonda Patrick compares her and Peter Attia’s supplement doses, including B vitamins, electrolytes, magnesium, and melatonin.
Dr. Rhonda Patrick reviews egg nutrients, substitution bias, lipid trials, ApoB response, diabetes, and practical intake.
Dr. Rhonda Patrick reviews creatine for performance, recovery, healthy aging, dosing, safety, kidney concerns, and hair-loss claims.
Dr. Rhonda Patrick compares semaglutide and tirzepatide, including incretin biology, trial results, regain, side effects, and long-term use.
Dr. Rhonda Patrick explains why AG1 is best viewed as a drinkable multivitamin, not a substitute for greens, fruit, or whole foods.
Dr. Rhonda Patrick explains how to build muscle with a nutrient-dense calorie surplus and what to look for in whey protein isolate.
Dr. Rhonda Patrick explains how brief exercise snacks can improve post-meal glucose, interrupt sitting, and add vigorous movement to the day.
Dr. Rhonda Patrick shares an organic-buying framework and explains why pesticide concerns should not crowd out nutrient-rich produce.
Dr. Rhonda Patrick explains how cumulative micronutrient insufficiency, omega-3 status, and magnesium shape food choices.
Dr. Rhonda Patrick explains VO2 max, vigorous interval options, and a practical 12-minute field estimate.
Dr. Rhonda Patrick explains protein targets, food sources, resistance training, and why it is never too late to build strength.
Dr. Rhonda Patrick explains sauna, heat-shock proteins, muscle-preservation evidence, and why controlled heat is not exercise.
Dr. Rhonda Patrick builds a blueberry smoothie and explains carotenoids, omega-3 forms, AG1, and high-PPO ingredient conflicts.
Dr. Rhonda Patrick explains magnesium reserves, nutrient interactions, food-first intake, and its limited role in hypertension.
Dr. Rhonda Patrick explains how stress and exercise can alter circulating or urinary magnesium without proving depleted body stores.
Dr. Rhonda Patrick explains how magnesium supports DNA repair and why low intake may contribute to accumulated cellular damage.
Dr. Rhonda Patrick reviews magnesium, brain health, and one cited crossover trial of magnesium oxide for migraine prevention.
Dr. Rhonda Patrick compares magnesium forms, L-threonate study limits, urinary absorption markers, and the transdermal evidence gap.
Dr. Rhonda Patrick explains cardiac training, lactate-brain signaling, and an emerging exercise mechanism in cancer care.
Dr. Rhonda Patrick explains why VO2 max tracks longevity and how vigorous intervals can improve cardiorespiratory fitness.
Dr. Rhonda Patrick explains how the omega-3 index relates to longevity and how testing can guide diet or supplementation.
Dr. Rhonda Patrick separates vitamin D animal, surrogate, genetic, and mortality evidence and explains why outcomes matter.
Dr. Rhonda Patrick discusses sauna, heat shock proteins, dementia associations, and controlled hyperthermia research in depression.
Dr. Rhonda Patrick shares her sauna routine, heat-adaptation approach, hydration practices, and caution when moving from heat to cold.
Dr. Rhonda Patrick explains sauna as an exercise mimetic, its healthspan associations, endurance research, and heat acclimation.
Dr. Brad Schoenfeld explains how training load, effort, proximity to failure, and weekly volume shape muscle growth.
Dr. Brad Schoenfeld explains numeric protein targets, lean-weight calculations, older-adult leucine, whole foods, and timing.
Dr. Martin Gibala compares direct laboratory VO2 max testing with attributed submaximal and questionnaire estimates.
Dr. Rhonda Patrick and Dr. Martin Gibala separate emerging lactate and shear-force mechanisms from a personal HIIT protocol.
Dr. Martin Gibala explains how brief vigorous activity in daily life relates to mortality and reduced sedentary time.
Dr. Martin Gibala explains how exercise intensity, training dose, and baseline fitness influence VO2 max improvements.
Dr. Peter Attia explains how exercise, sleep, energy balance, and glucose patterns influence insulin sensitivity.
Dr. Peter Attia explains breast-imaging tradeoffs, radiation, false positives, and how liquid biopsy complements screening.
Dr. Peter Attia explains statin benefits, blinded symptom evidence, cognition limits, Zone 2 testing, and nonstandard sterol monitoring.
Dr. Peter Attia explains a two-week home blood-pressure protocol and separates trial evidence from mechanisms and anecdotes.
Dr. Peter Attia explains how lactate, heart rate, perceived effort, and the talk test can help identify Zone 2 exercise.
Dr. Peter Attia explains cumulative ApoB exposure, four causal risks, numeric targets, diet mechanisms, and variable response.
Dr. Peter Attia explains symptom-based TRT trials, his dosing practice, blood-pressure monitoring, and updated CV safety evidence.
Dr. Peter Attia explains how he balances steady Zone 2 work with longer intervals that target VO2 max.
Dr. Peter Attia details his personal sleep, diet, exercise, supplement, and mental-health routine.
Dr. Rhonda Patrick explains lactate transport, brain fuel and antioxidant pathways, TBI research, and emerging vascular signaling.
Dr. Rhonda Patrick explains how vigorous exercise challenges mitochondria, glucose disposal, and cardiovascular fitness.
Dr. Rhonda Patrick explains VO2 max associations, interval options, heart-rate guidance, and practical Cooper-test estimates.
Dr. Rhonda Patrick explains EPA and DHA sources, conversion limits, membrane and inflammation roles, and Omega-3 Index caveats.
Dr. Rhonda Patrick explains magnesium intake, foods, observational health links, her supplement practice, and safety limits.
Dr. Rhonda Patrick uses vitamin D to explain food-first micronutrient adequacy, gene regulation, blood status, and clinical limits.
Dr. Rhonda Patrick shares her interval routine and explains exercise, sleep-loss, mortality, muscle, and skin-aging evidence.
Dr. Rhonda Patrick explains a fish-oil checklist: EPA/DHA concentration, form, oxidation, mercury, PCBs, and lot testing.
In this clip, Dr. Martin Gibala examines the cognitive benefits of HIIT and the emerging insights on lactate's role in brain health.
In this clip, Dr. Martin Gibala weighs the risks vs. benefits of interval training across ages, highlighting its advantage over sedentary life.
In this clip, Dr. Martin Gibala emphasizes tailoring HIIT to one's fitness level by briefly exceeding comfort zones.
In this clip, Dr. Martin Gibala discusses how functional training simultaneously boosts cardiorespiratory fitness and muscle conditioning.
In this clip, Dr. Martin Gibala explains how vigorous activity activates both slow and fast-twitch muscles and the impact of aging on these fibers.
In this clip, Dr. Martin Gibala delves into the nuances of sex-based differences in exercise response and their implications for individual outcomes.
In the clip, Dr. Gibala discusses high-intensity interval training's future, stressing translating research into public health applications.
In this clip, Dr. Martin Gibala examines how different HIIT exercises influence bone growth and joint issues.
In this clip, Dr. Martin Gibala outlines the relationship between exercise types, mitochondrial growth, and their combined effect on fat metabolism.
In this clip, Dr. Martin Gibala explains VO2 max's role in health and how non-athletes can optimize workouts to boost their cardiorespiratory fitness.
In this clip, Dr. Martin Gibala explores HIIT's effects on VO2 max, highlighting the importance of personalized exercise routines.
In this clip, Dr. Martin Gibala discusses the 'afterburn effect' and its impact on post-workout metabolism.
In this clip, Dr. Martin Gibala discusses the ongoing studies and their objectives in understanding the impact of "exercise snacks".
In this clip, Dr. Martin Gibala outlines the principle behind VILPA and discusses the ongoing research examining its potential impact on health and longevity.
In this clip, Dr. Martin Gibala highlights the benefits of high-intensity sprint training for general fitness and elite athletes.
In this clip, Dr. Martin Gibala describes the benefits and public health potentials of Reduced Exertion High-Intensity Training.
In this clip, Drs. Rhonda Patrick and Chris McGlory describe the evidence suggesting that omega-3 fatty acids augment muscle development.
In this clip, Dr. McGlory discusses the pros and cons of combining aerobic conditioning and resistance training.
In this clip, Dr. Chris McGlory discusses the potential role of omega-3 fatty acids in muscle health, especially in the context of cancer cachexia.
In this clip, Dr. Chris McGlory explains the potential mechanisms by which omega-3s impact muscle mass and function.
In this clip, Dr. McGlory discusses the intriguing interplay between resistance training, nutrition, and muscle adaptation, especially among older adults.
In this clip, Dr. Chris McGlory defines the importance of preloading omega-3s and suggests that effects may require higher doses.
In this clip, Dr. McGlory discusses the potential of omega-3 fatty acids to protect against muscle loss during periods of immobilization or inactivity.
In this clip, Dr. Chris McGlory emphasizes that even brief periods of reduced physical activity have health impacts that are frequently overlooked.
In this clip, Dr. McGlory describes the mechanisms and implications of muscle disuse atrophy and the limitations of nutrition in combating this issue.
In this clip, Dr. Axel Montagne discusses the potential of these emerging diagnostic tools in assessing an individual's risk of developing dementia.
In this clip, Dr. Axel Montagne explains the damaging effects of chronic high blood pressure on the brain.
Dr. Axel Montagne discusses pursuing cyclophilin A, MMP9, or blood-brain barrier proteins as targets for new Alzheimer's disease therapies.
In this clip, Dr. Axel Montagne describes the dire consequences of a dysfunctional blood-brain barrier.
In this clip, Dr. Axel Montagne highlights the blood-brain barrier changes that potentially contribute to Alzheimer's disease.
In this clip, Dr. Axel Montagne describes the potential link between omega-3 fatty acids, inflammation, and brain health.
Dr. Axel Montagne discusses the importance of blood-brain barrier integrity, especially for people with APOE4, who have higher Alzheimer's disease risk.
In this clip, Dr. Montagne discusses promising targets for protecting brain vessels to delay Alzheimer's.
In this clip, Dr. Axel Montagne discusses how the brain transport of omega-3 DHA may be important for the prevention and possibly as a therapy for dementia.
Many factors promote inflammation but reducing these factors in our lives will likely improve our aging.
In this clip, Dr. Axel Montagne highlights how 90 percent of our brain vasculature are tiny blood vessels - without exercise, they collapse, and neurons die.
In this clip, Dr. Brad Schoenfeld outlines his current fitness routine, including resistance and aerobic training.
In this clip, Dr. Brad Schoenfeld describes how blood flow restriction is used, its advantages, and possible drawbacks.
In this clip, Dr. Brad Schoenfeld explains how resistance training and flexibility go hand in hand.
In this clip, Dr. Brad Schoenfeld explains how to incorporate resistance and endurance training into workout routines.
In this clip, Dr. Brad Schoenfeld discusses soreness after resistance training and gives some strategies to alleviate it.
In this clip, Dr. Brad Schoenfeld discusses the importance of recovery in building muscle mass and strength.
In this clip, Dr. Brad Schoenfeld details the minimum effective dose that will allow most people to maximize muscle hypertrophy.
In this clip, Dr. Brad Schoenfeld discusses balancing effort and rest to optimize muscle hypertrophy and strength gains.
In this clip, Dr. Brad Schoenfeld discusses why it is important to incorporate some form of power training in resistance exercise programs.
In this clip, Dr. Brad Schoenfeld describes how his opinion about lifting light loads has changed over the years.
In this clip, Dr. Brad Schoenfeld discusses how practicing time-restricted eating influences lean muscle mass retention.
In this clip, Dr. Brad Schoenfeld discusses the importance of eating enough protein during resistance training to maintain and build muscle mass.
In this clip, Dr. Brad Schoenfeld describes the importance of resistance training and adequate protein intake to prevent losing muscle mass during weight loss.
In this clip, Dr. Brad Schoenfeld discusses the benefits of starting and maintaining resistance training across the lifespan.
In this clip, Dr. George Church describes the pros and cons of animal research and how we could move beyond its use with advanced technologies.
In this clip, Dr. George Church discusses how gene editing could uniquely improve human life in the future.
In this clip, Dr. George Church discusses these findings and what they could mean for the future of public health.
In this clip, Dr. George Church explains how sleeping and dreaming can inspire scientific ideas and artistic vision.
In this clip, Dr. George Church discusses the opportunities and possible dangers of tools for genetic engineering.
In this clip, Dr. George Church discusses how aging might be reversed and what animal research can tell us about human aging.
In this clip, Dr. George Church discusses how engineering animal organs may make them suitable for human transplant.
In this clip, Dr. George Church shares insights on the future of gene therapies in healthcare.
In this clip, Dr. George Church describes how gene writing projects could deliver health benefits for future generations.
In this clip, Dr. George Church describes Genome Project-Write, its goals, and the technology fueling it.
Dr. George Church explains how multiplex genome editing and genome writing could transform human health and enable other breakthroughs.
In this clip, Dr. George Church discusses the Human Genome Project and how it has revolutionized many areas of science.
In this clip, Dr. Stuart Phillips outlines steroid biochemistry and why he thinks testosterone boosters don't work.
In this clip, Dr. Stuart Phillips describes how omega-3 fatty acids may contribute to slow age-related declines in muscle mass and strength.
In this clip, Dr. Stuart Phillips discusses how growth hormone promotes collagen synthesis and how this might relate to muscle strength.
In this clip, Dr. Stuart Phillips discusses whether it is important to distribute protein intake equally throughout the day.
In this clip, Dr. Stuart Phillips describes how muscle mass and strength decline with age and outlines the importance to maintaining quality of life.
In this clip, Dr. Stuart Phillips describes his current lifestyle to optimize health and longevity.
In this clip, Dr. Stuart Phillips discusses whether plant-derived proteins can support hypertrophy.
Dr. Stuart Phillips discusses how building muscle reserves with adequate nutrition delays the disability threshold and supports successful aging.
In this clip, Dr. Stuart Phillips discusses creatine monohydrate and its effects on brain and muscle health.
In this clip, Dr. Stuart Phillips discusses how heat stress promotes muscle health and reduces muscle loss.
In this clip, Dr. Stuart Phillips discusses the implications of hormones in muscle mass growth and compares physiological to supraphysiological doses.
Dr. Stuart Phillips describes differences in muscle protein synthesis between young and older adults and declining protein-use efficiency with age.
In this clip, Dr. Stuart Phillips explains the importance of dietary protein quality and the role of the amino acid leucine in muscle protein synthesis.
In this clip, Dr. Stuart Phillips discusses his concerns regarding the current protein recommended dietary allowances.
In this clip, Dr. Stuart Phillips and Dr. Rhonda Patrick discuss the importance of building and maintaining muscle mass for longevity.
Dr. Levine shares personal habits she has developed to slow aging, including exercise, a plant-based diet, and time-restricted eating.
In this clip, Drs. Patrick and Levine discuss the reliability of epigenetic age tests available to consumers.
In this clip, Drs. Levine and Patrick discuss lifestyle factors that accelerate epigenetic aging including smoking cigarettes or having a low omega-3 index.
In this clip, Drs. Levine and Patrick discuss the epigenetic changes that occur with age, including methylation of CpG sites.
In this clip, Drs. Levine and Patrick discuss how genes that are important for embryonic development can tell us a lot about aging.
Drs. Levine and Patrick discuss how and why individuals age at different rates and how menopause & obesity may increase an individual's rate of aging.
In this clip, Drs. Levine and Patrick discuss the advantage of using epigenetic clocks in aging research to measure biological age.
Drs. Levine and Patrick discuss advances showing that cellular aging can be reversed and stem cells generated from differentiated cells.
In this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists.
In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging.
Why "second generation" epigenetic clocks are better at detecting biological age | Dr. Morgan Levine
Dr. Morgan Levine explains how second-generation clocks, including PhenoAge and GrimAge, more accurately detect biological age and age acceleration.
In this clip, Dr. Dominic D'Agostino gives his thoughts on eating an all-meat diet and weighs in on whether it is optimal to eat a diet devoid of fiber.
In this clip, Dr. Dominic D'Agostino discusses the implications of adding a ketogenic diet to cancer treatment protocols.
In this clip, Dr. Dominic D'Agostino describes how nutritional ketosis may support the treatment of neurodegenerative and other brain disorders.
In this clip, Dr. Dominic D'Agostino describes animal research that explores the mechanisms by which the ketogenic diet may benefit the brain.
In this clip, Dr. Dominic D'Agostino discusses how ketones affect exercise performance.
In this clip, Dr. Dominic D'Agostino describes strategies to incorporate other fasting modalities into a ketogenic lifestyle diet.
In this clip, Dr. Dominic D'Agostino discusses how ketones produced during fasting and ketosis protect against muscle loss.
In this clip, Dr. Dominic D'Agostino discusses the supplements he thinks pair well with a ketogenic diet.
In this clip, Dr. Dominic D'Agostino outlines the advantages and disadvantages of various ways of quantifying ketosis.
In this clip, Dr. Dominic D'Agostino discusses the applicability of a ketogenic diet for people with an APOE4 gene variant.
In this clip, Dr. Dominic D'Agostino describes how breath acetone concentration is a non-invasive tool for measuring fat loss.
In this clip, Dr. Dominic D'Agostino outlines strategies to initiate a ketogenic diet and mitigate its side effects.
In this clip, Dr. Dominic D'Agostino details the macronutrient ratios that make up the broad spectrum of ketogenic diets.
In this clip, Dr. Matthew Walker explains how altering the timing and duration of daytime light exposure influences sleep.
Autophagy facilitates ATP release from dying cells, triggering immunosurveillance by attracting myeloid cells through purinergic receptors.
In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.
Fasting as Healthspan Maintenance, Relevance for Tissue Rejuvenation, Cancer & More | Rhonda Patrick
Dr. Patrick discusses early evidence on prolonged fasting of 48 or more hours for tissue rejuvenation, healthspan maintenance, and specific conditions.
In this clip, Dr. Valter Longo explains how certain macronutrients influence the insulin/IGF-1/growth hormone axis to modulate aging in many cell types.
In this clip, Dr. Griffiths talks about the effect of dose on psilocybin mystical experiences and ‘bad trips’.
In this clip, Dr. Jed Fahey describes the beneficial effects of sulforaphane in modulating the symptoms of autism and other brain disorders.
In this clip, Dr. Patrick talks about the effects of nicotinamide mononucleotide on cancer growth.
In this clip, Dr. Rhonda Patrick discusses the many ways in which sulforaphane aids the body in excreting harmful compounds.
In this clip, Rich Roll describes the events that led up to him becoming vegan.
In this clip, Rich Roll describes how the development of his ultra-endurance racing career started after he switched to a plant-based diet.
In this clip, Rich Roll and Dr. Rhonda Patrick discuss the dietary deficiencies common in vegan and non-vegan diets.
In this clip, Rich Roll describes the features of his vegan diet and how he avoids any micronutrient deficiencies.
In this clip, Dr. Ronald Krauss discusses that in clinical practice, cholesterol particle size may be more relevant than the amount of cholesterol.
In this clip, Dr. Ronald Krauss discusses the complexities of HDL cholesterol and its relationship to heart disease risk.
In this clip, Dr. Ronald Krauss discusses the possible protective role of LDL cholesterol.
In this clip, Dr. Ronald Krauss describes why it may be more beneficial to reduce LDL levels than to raise HDL levels.
In this clip, Dr. Ronald Krauss discusses the role of inflammation in lipoprotein metabolism.
In this clip, Dr. Ronald Krauss debunks common myths of dietary cholesterol and saturated fat.
In this clip, Dr. Ronald Krauss shares his experience in research showing heart disease risk is more influenced by sugar consumption than fat consumption.
In this clip, Dr. Ronald Krauss explains how simple sugars are the culprit for many of the diseases he has studied.
Dr. Krauss believes that the future of research funding should come from philanthropic sources that eliminates any risk of conflicts of interest.
In this clip, Bruce provides both an evolutionary and a molecular rationale for his theory.
In this clip, Bruce Ames describes how folate is critical for the transferring of single-carbon groups between molecules.
In this clip, Ronald Krauss discusses the negative combinative effect of consuming added sugars and saturated fat together.
In this clip, Rhonda talks about the difference between vitamin K1 and K2.
In this clip, Bruce Ames explains that recommended daily allowance (RDA) is set at two standard deviations above the estimated average requirement (EAR).
In this clip, Dr. Rhonda Patrick reviews the recently published data on children's susceptibility to COVID-19.
In this clip, Dr. Rhonda Patrick describes the different blood types and how they influence immunity.
Dr. Rhonda Patrick discusses the safety and side effects of intravenous vitamin C and evidence supporting its use for treating COVID-19.
In this clip, Dr. Rhonda Patrick discusses the potential uses for melatonin in treating COVID-19.
In this clip, Dr. Rhonda Patrick discusses the research of how sauna-use reduces the risk of respiratory infections with implications for COVID-19.
Bruce Ames explains how the eye carotenoids lutein and zeaxanthin mitigate harmful effects of singlet oxygen produced by sunlight.
In this clip, Bruce Ames explains how vitamin D functions as both a vitamin and a hormone.
In this clip, Bruce Ames says that although he eats a very healthy diet, he still takes a vitamin D supplement.
In this clip, Bruce Ames emphasizes the importance of proper nutrition for prevention of diseases.
Dr. Rhonda Patrick describes harmful effects of nicotine and cigarette-smoke exposure on breast milk quality and breastfeeding duration.
In this clip, Dr. Rhonda Patrick describes the strange phenomenon and role of mammary stem cells in breast milk.
In this clip, Dr. Rhonda Patrick describes the unique community of microbes present in human breast milk.
In this clip, Dr. Rhonda Patrick discusses the risks associated with maternal consumption of caffeine.
In this clip, Dr. Rhonda Patrick discusses how breastfeeding benefits mothers and describes some of the challenges women who breastfeed face.
In this clip, Dr. Rhonda Patrick describes the immune-boosting properties of breast milk.
Breastfeeding associated w/ improvements in cardiovascular health in adults who were preterm infants
In this clip, Dr. Rhonda Patrick describes how breastfeeding reduces the risk of cardiovascular complications associated with pre-term birth.
In this clip, Dr. Krauss discusses how statins reduce the risk of cardiovascular disease and potential for better drugs in the future.
Dr. Krauss explains that he believes both are impactful for correcting LDL levels and mitigating risk of cardiovascular disease.
In this clip, Dr. Krauss shares his thoughts on the prescription pattern of statins in the United States.
In this clip, Dr. Krauss discusses why women taking statins have higher risk for diabetes.
In this clip, Dr. Krauss talks about the necessity of the ion mobility test before starting statin therapy and the growing popularity of the test.
In this clip, Dr. Krauss discusses the indications for the ion mobility test.
In this clip, Dr. Krauss talks about LDL numbers that are considered high risk.
In this clip, Dr. Roger Seheult describes how calcifediol may be used in an acute care setting to ameliorate low vitamin D status.
In this clip, Rich Roll and Dr. Rhonda Patrick discuss how IGF-1 levels impact cancer risk.
In this clip, Rich Roll and Dr. Rhonda Patrick discuss how those on a vegan diet can determine whether they are getting enough omega-3 fatty acids.
In this clip, Rich Roll and Dr. Rhonda Patrick discuss the differences between nitrites, nitrates, and nitrosamines and their cancer-causing potential.
In this clip, Dr. Mark Mattson outlines the differences between intermittent fasting and a ketogenic diet concerning benefits to the brain.
In this clip, Dr. Mark Mattson delivers an overview of the research investigating the effects of intermittent fasting on female and stress hormones.
In this clip, Dr. Mark Mattson discusses the pros and cons of calorie restriction mimetics.
In this clip, Dr. Mark Mattson describes how ketone esters may improve brain health.
In this clip, Dr. Mark Mattson describes how fasting and exercise work together to promote brain health.
In this clip, Dr. Mark Mattson describes the importance of incorporating rest, recovery, and refeeding into one's routine.
In this clip, Dr. Mark Mattson discusses our fascinating coevolution with plants and why mildly toxic phytochemicals promote longevity better than antioxidants.
In this clip, Dr. Mark Mattson discusses the importance of maintaining muscle mass during aging.
In this clip, Dr. Mark Mattson discusses the differences between styles of intermittent fasting and time-restricted eating.
In this clip, Dr. Mark Mattson describes the importance of transient, short-term, mild energetic stress to maintain healthy cells.
In this clip, Dr. Mark Mattson predicts that intermittent fasting benefits both overweight and healthy weight people.
In this clip, Dr. Mark Mattson explains the importance of stressing the cardiovascular system with behaviors such as exercise and fasting to maximize health.
In this clip, Dr. Mark Mattson shares his opinions regarding the possible life-extension properties of intermittent fasting.
Dr. Rhonda Patrick, Dr. Darya Rose, and Kevin Rose discuss turmeric's ability to increase detoxification enzymes through hormesis.
Darya Rose talks about her 10 day silent retreat.
In this clip, Dr. Darya Rose talks about quick overview of which foods correspond to different seasons in the year.
Kevin discusses his ketogenic-diet experiments, which pair large amounts of vegetables with fats to drive ketosis, along with other projects.
In this video, Dr. Darya & Kevin Rose talk about fasting, beta-hydroxybutyrate and the fasting-mimicking diet.
In this clip, Dr. Satchin Panda talks about how time-restricted eating affects leaky gut and systematic inflammation.
Dr. Ashley Mason explains differences between sauna use and whole-body hyperthermia, its potential for depression, and a planned clinical trial.
In this clip, Dr. Ashley Mason describes elements of cognitive behavioral therapy for insomnia.
In this clip, Dr. Ashley Mason describes what drives insomnia and how the condition can be treated.
In this clip, Dr. Ashley Mason describes how mindfulness, a cognitive behavioral strategy, can help mitigate harmful behaviors like overeating and smoking.
In this clip, Dr. Ashley Mason describes how cognitive behavioral therapy for insomnia helps people take control of their thoughts to improve their sleep.
In this clip, Dr. Eran Elinav outlines the counter-intuitive discovery that artificial sweeteners may dysregulate glucose metabolism.
In this clip, Dr. Eran Elinav describes the personalized nutrition project and how someone can replicate these findings using a continuous glucose monitor.
Lifestyle tips from a microbiome expert: TMAO concerns, influence of smoking, sleep, and food timing
In this clip, Dr. Eran Elinav discusses generalizable ways to foster a healthy gut microbiome.
In this clip, Dr. Eran Elinav explains the new field of bacteriophages and how they could be combined with probiotics to generate personalized therapies.
In this clip, Dr. Eran Elinav discusses the intestinal barrier's important role in absorbing nutrients while keeping out pathogens.
In this clip, Dr. Eran Elinav discusses the microbiome-related dynamics of weight regain and why some people have difficulty maintaining weight loss.
In this clip, Dr. Eran Elinav describes research suggesting that the microbiome modulates fatty acid metabolism.
In this clip, Dr. Eran Elinav discusses the importance of the early childhood period in shaping a healthy microbiome.
In this clip, Dr. Eran Elinav highlights several factors that contribute to a diverse microbiome.
In this clip, Dr. Eran Elinav describes how the circadian rhythmicity of the microbiome is regulated and how this affects human health.
In this clip, Dr. Bill Harris discusses the importance of the omega-3 fatty acid DHA in the developing brain.
In this clip, Dr. Bill Harris describes the recent large clinical trials evaluating whether omega-3 decreases heart disease risk.
In this clip, Dr. Bill Harris and Dr. Rhonda Patrick discuss how concerns over the omega-6/omega-3 ratio may be unfounded.
In this clip, Dr. Bill Harris discusses the correlative and in silico data suggesting that omega-3 DHA may play a dual role against COVID-19.
In this clip, Dr. Bill Harris highlights a novel area of research — the role omega-3s play in altering red blood cell biology.
In this clip, Dr. Bill Harris discusses the central role omega-3 plays in resolving inflammation and how this impacts heart disease risk.
In this clip, Dr. Bill Harris discusses the impact omega-3 levels have on the risk of death from cardiovascular disease, cancer, and other diseases.
Drs. Bill Harris and Rhonda Patrick discuss a questionable, potentially spurious association of omega-3 and selenium supplements with prostate cancer.
In this clip, Dr. Bill Harris discusses the evidence surrounding omega-3 supplementation and the risk for atrial fibrillation or irregular heart rhythms.
In this clip, Dr. Bill Harris provides his nuanced insights into whether omega-3 supplementation carries a bleeding risk.
In this clip, Dr. Bill Harris discusses the development of the Omega-3 Index and the importance of measuring biomarkers in assessing omega-3 status.
In this clip, Dr. Bill Harris describes his early research using high doses of omega-3 fatty acids, which uncovered their surprising effects on triglycerides.
In this clip, Dr. Roger Seheult describes ivermectin and its possible role against COVID-19.
In this clip, Dr. Roger Seheult clarifies the ambiguity surrounding how physicians report deaths and comorbidities from COVID-19.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss whether COVID-19 vaccines impact fertility.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick describe long-haul COVID-19 and its ramifications for young people.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick explain the history and future potential of technology.
In this clip, Dr. Roger Seheult discusses concerns about whether vaccines were rushed or can lead to more harmful forms of the virus.
In this clip, Dr. Rhonda Patrick discusses the relationship between vaccines and viral evolution.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how vaccines reduce viral transmission.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss whether medical alternatives such as ivermectin are as effective against COVID-19 as vaccines.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick describe why mRNA vaccines do not alter human genetics.
In this clip, Dr. Rhonda Patrick discusses whether mRNA COVID-19 vaccines spread to different organs.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss why antibody-dependent enhancement is unlikely to occur with COVID-19 vaccines.
In this clip, Dr. Roger Seheult explains how vaccine safety data is collected using the VAERS reporting system.
In this clip, Dr. Rhonda Patrick describes what distinguishes viral spike proteins from vaccine-related spike proteins.
In this clip, Dr. Roger Seheult shares his experience caring for young unvaccinated COVID-19 patients in the hospital.
In this clip, Dr. Satchin Panda discusses factors that determine our daily energy fluctuations and how we can counteract low periods.
In this clip, Dr. Satchin Panda describes how circadian rhythms regulate processes including eating behaviors, problem-solving ability, and mood.
In this clip, Dr. Satchin Panda describes the factors determining the best time for exercise according to our circadian clocks.
In this clip, Dr. Satchin Panda describes his smart app MyCircadianClock and how it is helping the research surrounding time-restricted eating.
In this clip, Dr. Satchin Panda explains the rationale behind the metabolic benefits associated with time-restricted eating.
Dr. Satchin Panda describes how managing indoor lighting can regulate circadian rhythms and counter the detrimental health effects of modern lifestyles.
Dr. Satchin Panda explains how shift work and modern lifestyles disrupt circadian rhythms and metabolic health, and approaches that may help shift workers.
In this clip, Dr. Satchin Panda describes the relationship between melatonin and insulin and how this might determine the best time to eat.
In this clip, Dr. Satchin Panda describes the pharmacokinetics and possible benefits and drawbacks of taking supplemental melatonin.
Dr. Satchin Panda explains how light affects the circadian clock and why dimming lights and avoiding devices at night lets melatonin rise.
In this clip, Dr. Satchin Panda summarizes tips and strategies that anyone can follow to ensure a healthy circadian clock.
In this clip, Dr. Satchin Panda describes his habits and addresses questions surrounding the issue of whether time-restricted eating is suitable for everyone.
In this clip, Dr. Michael Snyder describes how the human microbiome plays a key role in health, immunity, and nutrition.
In this clip, Dr. Michael Snyder describes aspects of his lifestyle routine that he tracks with wearables.
Dr. Michael Snyder discusses how distinct patterns and rates of aging may define an ageotype and identify targets to prevent age-related disease.
Poor air quality has been linked with effects on human health, ranging from asthma to Alzheimer's disease.
Dr. Michael Snyder describes how continuous glucose monitoring and awareness of his genetic risk led to his type 2 diabetes diagnosis.
Dr. Michael Snyder's research suggests exercise triggers profound molecular changes, particularly in immune molecules.
Traditional medicine focuses on treating rather than preventing diseases — a model that Dr. Snyder describes as "broken."
If a participant's heart rate jumps up for a prolonged period, it might suggest a physiological response to infection.
Continuous glucose monitors, or CGMs, are wearable devices that allow users to monitor their blood glucose levels through a tiny sensor placed under the skin.
In this clip, Dr. Rhonda Patrick describes what Mendelian randomization studies are and how they are valuable instruments in the scientific toolbox.
In this clip, Dr. Roger Seheult explains how vitamin D is a misnomer and how it fulfills many critical roles in the body.
In this clip, Dr. Roger Seheult discusses how he has always had a passion for teaching and simplifying complex topics.
In this clip, Dr. Roger Seheult describes his personal experience treating COVID-19 patients in the hospital.
In this clip, Dr. Roger Seheult describes how treatment modalities differ between the two distinct phases of COVID-19 illness.
In this clip, Dr. Roger Seheult describes how mRNA vaccines stimulate the body's immune system to produce antibodies.
In this clip, Dr. Roger Seheult discusses the importance of getting enough sleep for proper immune functioning and resisting viral infections.
In this clip, Dr. Roger Seheult explains the different parts of sleep and the value of each phase.
In this clip, Dr. Roger Seheult addresses the importance of the interferon response in the body's defense against viruses.
In this clip, Dr. Roger Seheult describes how a diminished interferon response drives poor outcomes in COVID-19.
In this clip, Dr. Roger Seheult discusses the biological plausibility of incorporating heat hydrotherapy into the treatment of COVID-19.
In this clip, Dr. Roger Seheult explains that well-ventilated spaces are a factor in dampening the spread of the SARS-CoV-2 virus.
Drs. Roger Seheult and Rhonda Patrick discuss how vitamin D levels may affect the renin-angiotensin system and COVID-19 outcomes.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how to assess vitamin D requirements and its toxicity potential.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how to assess vitamin D requirements and its toxicity potential.
In this clip, Dr. Roger Seheult describes the interesting similarity between COVID-19 risk factors and vitamin D deficiency risk factors.
In this clip, Dr. Roger Seheult explains how the current COVID-19 vaccines differ and describes his personal immunization experience.
Dr. Steve Horvath discusses research suggesting caloric restriction, especially when reversing obesity or metabolic syndrome, may slow epigenetic aging.
In this clip, Dr. Steve Horvath discusses whether epigenetic clocks play causal roles in aging.
Methylation and demethylation are critical to development, and disrupting the enzymes that control them can affect epigenetic age.
Some epigenetic clock evidence reinforces the idea that accelerated aging may be a consequence of chronic inflammation.
Techniques that differentiate or transdifferentiate cells, such as fibroblasts into neurons, reveal interesting effects on epigenetic age.
In a mouse model of premature aging, short-term expression of four age-reversing factors improved aging hallmarks and prolonged lifespan.
The epigenetic clocks of transplanted cells and their descendants synchronize with the donor, offering promise for human rejuvenation.
Healthy eating, physical activity, and education are weakly linked to slower epigenetic aging; obesity, sleep deprivation, and smoking to faster aging.
In this clip, Dr. Steve Horvath discusses how epigenetic aging differs from senescence-mediated aging.
The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres.
A person's epigenetic age correlates with their risk for developing major diseases of aging like cancer, Alzheimer's disease, and Parkinson's.
The stability of methylation patterns on DNA samples means the data can be trusted more in the lab when investigating anti-aging interventions.
The GrimAge clock predicts lifespan and healthspan in years and tests whether lifestyle interventions may slow or reverse biological aging.
In this clip, Dr. Steve Horvath explains the differences between chronological age and biological age.
Clinical biomarkers do not always reflect how well a person is aging, but epigenetic clocks may offer a more reliable measure.
Evidence suggests epigenetic aging is about 40 percent heritable, as seen in supercentenarians and their offspring, who tend to age more slowly.
Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging.
In this clip, sulforaphane expert Dr. Jed Fahey describes some of the problems associated with choosing a good source of seeds for sprouting.
In this clip, Dr. Jed Fahey enumerates the vegetables in which sulforaphane is found.
In this clip, Dr. Jed Fahey describes how long the health effects of broccoli sprouts last.
In this clip, Dr. Jed Fahey discusses how sulforaphane promotes glutathione production in the brain, even with long-term consumption.
In this clip, Dr. Jed Fahey describes how sulforaphane facilitates the detoxication of heavy metals by increasing glutathione synthesis.
In this clip, Dr. Jed Fahey describes sulforaphane's opposing effects on cancer.
In this clip, Dr. Jed Fahey discusses the effects of urinary excretion of sulforaphane byproducts.
In this clip, Dr. Jed Fahey discusses the current state of the science regarding sulforaphane and brain health.
In this clip, Dr. Jed Fahey discusses the pros and cons of sprouting and whether broccoli seeds contain erucic acid.
Dr. Jed Fahey discusses a protocol for maximizing glucoraphanin in broccoli sprouts to obtain the highest sulforaphane concentration.
In this clip, Dr. Jed Fahey discusses strategies for disguising the flavor of broccoli sprouts.
Dr. Jed Fahey discusses whether microwaving preserves enough heat-sensitive myrosinase to convert glucoraphanin into sulforaphane.
In this clip, Dr. Jed Fahey describes how sulforaphane promotes the excretion of toxicants in air pollution.
In this clip, Dr. Jed Fahey describes the best way to store broccoli sprouts.
In this clip, Dr. Jed Fahey discusses the beneficial health effects of moringa.
In this clip, Dr. Rhonda Patrick shares anecdotal evidence that moringa reduces blood glucose levels.
In this clip, Dr. Jed Fahey names several reliable supplemental sources of sulforaphane.
In this clip, sulforaphane expert Dr. Jed Fahey describes some of the problems that complicate determining the optimal source and dose of sulforaphane.
In this clip, Dr. Jed Fahey disputes claims that sulforaphane causes goiters.
In this clip, Dr. Jed Fahey rebuts popular claims that an all-meat diet is healthful.
Broccoli sprout intake depends on individual tolerance; 2 to 4 ounces of sprouts daily is a reasonable, healthy goal.
In this clip, Dr. Giselle Petzinger describes her recommended components for an exercise program for people with Parkinson's disease.
Dr. Giselle Petzinger explains there is no evidence diet or exercise can cure Parkinson's disease or eliminate dopamine replacement.
In this clip, Dr. Giselle Petzinger discusses how intense exercise can impact motor scores in people with Parkinson's disease.
Benefits of 1-on-1 therapy & group dynamics in exercise for Parkinson's patients | Giselle Petzinger
In this clip, Dr. Giselle Petzinger explains how to design an optimal exercise regimen for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger explains that strenuous exercise affects dopamine sensitivity in the brains of people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses how adding a cognitive load to an exercise program is important for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses the importance of incorporating intensity into the exercise routine for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger describes the specific characteristics of exercise that make it so helpful to people with Parkinson's disease.
Dr. Giselle Petzinger explains how exercise may promote resilience against the insults of Parkinson's disease.
In this clip, Dr. Giselle Petzinger highlights some of the risk factors for Parkinson's disease, and discusses how this is likely a multifaceted problem.
In this clip, Dr. Giselle Petzinger explains how the loss of dopamine disrupts circuitry in the brains of people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses Parkinson's disease and explains how symptoms can vary dramatically between people.
In this clip, Dr. Rhonda Patrick describes the data suggesting that maternal supplemental vitamin D can reduce the risk of deficiency in breastfed infants.
In this clip, Dr. Rhonda Patrick explains why iron levels in breast milk are low.
In this clip, Dr. Rhonda Patrick describes the importance of vitamin K for newborn infants.
In this clip, Dr. Rhonda Patrick discusses the importance of omega-3 fatty acids in breast milk and their relevance for infant brain development.
Milk Fat Globule Membranes (MFGMs) in breast milk affect development of gut, brain, and intelligence
In this clip, Dr. Rhonda Patrick describes the structure and function of milk fat globule membranes in breast milk.
In this clip, Dr. Rhonda Patrick describes the multifaceted roles of HMOs in breast milk.
Dr. Rhonda Patrick describes fluids produced during lactation and how their nutritional content meets an infant's needs.
In this clip, Dr. Rhonda Patrick goes over harmful substances that can get into breastmilk and negatively affect an infant’s health.
Dr. Rhonda Patrick discusses DHA bioavailability and her DHA regimen of dietary and supplemental omega-3 sources.
Dr. Patrick discusses sulforaphane–iodine interactions and advises people with iodine deficiency or hypothyroidism to monitor thyroid hormones with a doctor.
Dr. Rhonda Patrick discusses sulforaphane research on DNA damage and why the forms of studies matter.
In this clip, Dr. Rhonda Patrick describes advances in sulforaphane research that are particularly relevant to the brain.
In this clip, Dr. Rhonda Patrick describes the advantages and disadvantages of the various dietary and supplemental sources of sulforaphane.
Dr. Rhonda Patrick explains that promising magnesium L-threonate results in animal studies have not yet translated to humans.
In this clip, Dr. Rhonda Patrick talks about the importance of obtaining adequate magnesium in the diet.
Dr. Rhonda Patrick discusses adequate magnesium intake and her preferred dietary magnesium supplement.
In this clip, Dr. Rhonda Patrick discusses various sauna protocols that differ in temperature, timing, and frequency.
In this clip, Dr. Rhonda Patrick describes how the physiological effects observed during sauna use are comparable to those that occur during physical exercise.
In this clip, Dr. Rhonda Patrick discusses how heat can be used to increase muscle strength and counteract muscle wasting.
In this clip, Dr. Rhonda Patrick describes the effects of heat on mood, particularly in those experiencing depression.
Dr. Rhonda Patrick discusses whether taking metformin apart from exercise could reduce some adverse effects on exercise adaptation.
In this clip, Dr. Rhonda Patrick describes the many open questions that remain regarding the interaction between metformin and exercise at the molecular level.
In this clip, Dr. Rhonda Patrick gives her thoughts on whether healthy, active adults should take metformin.
In this clip, Dr. Rhonda Patrick describes the relationship between metformin and cancer incidence and the relevance for those with type 2 diabetes.
In this Q&A clip, Rhonda discusses Quercetin, the impact of it's antiviral activity, and it's role as a zinc ionophore.
Tim Ferriss' experience with floatation tanks & his desire to continue experimenting with meditation
In this clip, Dr. Rhonda Patrick discusses whether COVID-19 disease causes permanent lung damage.
In this clip, Dr. Rhonda Patrick describes the effect of sex hormones on immune function.
In this clip, Dr. Rhonda Patrick describes the effect of sex hormones on immune function.
In this clip, Dr. Rhonda Patrick discusses how omega-3 fatty acids participate in resolving inflammation during an immune response.
In this clip, Dr. Rhonda Patrick discusses the trace element zinc and its role in the immune system.
In this clip, Dr. Rhonda Patrick describes how vitamin C is involved in immunity.
In this clip, Dr. Rhonda Patrick discusses how vitamin A is involved in mounting an immune response.
In this clip, Dr. Rhonda Patrick details the critical role that vitamin D plays in the immune response.
In this clip Dr. Rhonda Patrick discusses how deficiencies or insufficiencies in micronutrients might negatively affect immune function.
In this clip, Dr. Rhonda Patrick describes how varying levels of exercise affect the immune response in different ways.
In this clip, Dr. Rhonda Patrick explains how allergens in the environment may shape the immune system during early life.
In this clip, Dr. Rhonda Patrick describes how the body's microbiome affects immune function.
In this clip, Dr. Rhonda Patrick discusses how a lack of sleep impacts the immune response.
In this clip, Dr. Rhonda Patrick discusses how the quantity and quality of antibodies against a virus might lead to negative outcomes.
In this clip, Dr. Rhonda Patrick discusses the role that genetics plays in the immune system.
In this clip, Dr. Rhonda Patrick discusses the active area of investigation surrounding the immune response to the SARS-CoV-2 virus.
In this clip, Dr. Rhonda Patrick discusses the evidence surrounding how long the virus resides in the human body.
In this clip, Dr. Rhonda Patrick discusses what cross-immunity is and how it may be relevant for SARS-CoV-2.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the specifics of restoring a healthy microbiome using probiotics.
Tim Ferriss describes using a ketogenic diet alongside antibiotics to support his recovery from Lyme disease.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the anti-cancer properties of the diabetes drug metformin.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the potential use of intravenous vitamin C as a supportive factor in the treatment of cancer.
Tim Ferriss and Dr. Rhonda Patrick discuss acute versus chronic inflammation and how supplemental antioxidants can reduce exercise benefits.
In this clip, Tim Ferriss describes his efforts to mitigate the risk of Alzheimer's disease by managing his insulin levels using the ketogenic diet.
In this clip, Tim Ferriss discusses his MTHFR status and his experience with vitamin supplementation.
In this clip, Tim Ferriss outlines the biomarkers that he measures routinely to make sure his health is on-track while following a ketogenic diet
In this clip, Tim Ferriss describes the biomarkers that he tracks to fine-tune his health and mental well-being.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss vasopressin and its effects on pair bonding in both animals and humans.
In this clip, Dr. Dominic D'Agostino discusses the importance of an individualized approach when considering glutamine supplementation.
In this clip, Dr. Dominic D'Agostino describes how gluconeogenesis fills an important role during ketosis to maintain a basal level of glucose.
In this clip, Dr. Dominic D'Agostino explains how the periodic use of fasting and associated practices may provide health benefits.
In this clip, Dr. Dominic D'Agostino discusses the therapeutic effects of ketones on cancer growth.
Dr. Dominic D'Agostino discusses the neuroprotective potential of combining ketones and lactate to manage traumatic brain injury.
In this clip, Dr. Dominic D'Agostino describes the positive effects that ketones can have on the brain.
In this clip, Dr. Dominic D'Agostino discusses the metabolic flexibility of the brain to use various substrates, including ketones, for energy.
Bioenergetic superiority of ketones and their role in reducing oxidative stress | Dominic D'Agostino
Dr. Dominic D'Agostino explains how ketones and lactate fuel the brain and how ketones may reduce oxidative stress through greater efficiency.
In this clip, Dr. Dominic D'Agostino discusses how the body adapts to a ketogenic diet and the possible impacts on age-related chronic diseases.
Dr. Dominic D'Agostino discusses the benefits of including fiber from diverse cooked and raw vegetable sources in a ketogenic diet.
In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.
In this clip, Dr. Dominic D'Agostino describes different approaches that allow the ketogenic diet to be more accessible.
In this clip, Dr. Dominic D'Agostino describes the parameters that affect an individual's response to ketosis.
In this clip, Dr. Dominic D'Agostino describes his research into the role of ketosis and ketone supplements in stabilizing brain energy metabolism.
Maintaining healthy vitamin D status may be an important, often overlooked factor in protecting against COVID-19-associated lung injury.
In this clip, Wim Hof shares his personal story that led to his passionate pursuit of how we can harness the body's innate ability to heal itself.
In this clip, Wim Hof describes the experiment in which scientists first discovered that his techniques were having a physiologically unexpected effect.
Wim Hof and Dr. Rhonda Patrick discuss how cold shock and controlled breathing may help treat depression, obsessive-compulsive disorder, and anxiety.
In this clip, Wim Hof discusses how his breathing techniques calm the mind and allow practitioners to access the parasympathetic system more immediately.
In this clip, Wim Hof describes how his breathing techniques affect the immune response and its potential use in combating disease.
In this clip, Wim Hof discusses how his breathing techniques may allow the body to tap into its natural disease-fighting abilities.
In this clip, Wim Hof describes how his breathing methods impact blood levels and can modify the body's response to pain.
In this clip, Wim Hof discusses how his breathing techniques can affect the body's pH level, yielding potential health benefits.
In this clip, Wim Hof describes how he controls his breath to deal with the discomfort of the cold.
In this clip, Wim Hof gives us some insight into how his fascination with the cold originally began.
In this clip, Dr. Ray Cronise emphasizes the importance of diet to improve healthspan rather than employing tricks to boost metabolic rate.
In this clip, Dr. Ray Cronise discusses his approach to choosing a diet to optimize healthspan.
In this clip, Dr. Ray Cronise and Dr. Rhonda Patrick discuss the importance of diet in maximizing healthspan and longevity.
In this clip, Dr. Ray Cronise shares his personal experiences with cold stress and weight loss.
In this clip, Dr. Peter Attia describes the potential use of lactate or beta-hydroxybutyrate in the treatment of traumatic brain injury.
In this clip, Dr. Peter Attia stresses the further risks of head trauma for those with the APOE4 gene variant.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick examine the use of various fuel sources in brain metabolism.
In this clip, Dr. Peter Attia addresses the challenges of balancing IGF-1 levels in the brain and body to promote neurogenesis without stimulating cancer.
In this clip, Dr. Peter Attia explains his position on the relationship between insulin resistance and Alzheimer’s disease risk.
In this clip, Dr. Peter Attia outlines the relative risk and biomarkers associated with some of the leading human diseases.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss the unique dietary and lifestyle considerations for carriers of the APOE4 gene variant.
In this clip, Dr. Peter Attia discusses the role of the APOE4 gene variant and the associated risk for Alzheimer’s disease and cardiovascular disease.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss how a healthy digestive tract interacts with the immune system to curb inflammation.
In this clip, Dr. Peter Attia describes his empirical strategy to obtain a personalized nutrition plan for longevity.
In this clip, Dr. Peter Attia explains the complex relationship that exists between cancer cells, the immune system, and IGF-1.
In this clip, Dr. Peter Attia explains the importance of the amino acid leucine and its role in the mTOR pathway.
In this clip, Dr. Peter Attia explains the interrelated mTOR and IGF-1 growth pathways and the delicate balance required to limit accelerated aging.
In this clip, Dr. Peter Attia explains the challenges involved in studying how diet and lifestyle affect longevity in humans.
Dr. Jed Fahey describes a study that demonstrated sulforaphane's chemoprotective qualities against benzene exposure.
Dr. Jed Fahey discusses the potential therapeutic benefit of sulforaphane in treating depression.
Dr. Jed Fahey describes the health benefits associated with moringin and discusses the chemical structure differences between it and sulforaphane.
Dr. Fahey describes the metabolic fate of sulforaphane and the current state of research on its effects against bladder cancer.
Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and the time frame required for full conversion.
Dr. Jed Fahey describes the effects of freezing and freeze-drying of broccoli sprouts on sulforaphane production.
Dr. Jed Fahey describes factors that influence isothiocyanate production.
Dr. Jed Fahey discusses the beneficial effects broccoli sprouts have in mediating the harmful effects of _H. pylori_.
Dr. Jed Fahey describes the beneficial effects of sulforaphane in modulating the symptoms of autism and other brain disorders.
Dr. Jed Fahey describes the current state of the science of understanding how sulforaphane influences longevity.
Drs. Jed Fahey and Rhonda Patrick discuss concerns about the safety and efficacy of probiotic supplements.
Dr. Jed Fahey discusses the importance of having active myrosinase in dietary supplements for optimizing the conversion of glucoraphanin to sulforaphane.
Dr. Jed Fahey discusses concerns about the sulforaphane dietary supplement industry and offers advice about how to choose quality products.
Dr. Jed Fahey describes some of the factors that influence the conversion of myrosinase-driven conversion of glucoraphanin to sulforaphane.
Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and cautions against preparation techniques that might inhibit their production.
Dr. Jed Fahey describes how sulforaphane was discovered, how it is produced in plants, and the mechanisms by which it produces health effects in humans.
Dr. Jed Fahey describes the early co-discoveries of sulforaphane and Nrf2, and describes the importance of the Nrf2 pathway.
In this clip, Dr. Erica Sonnenburg describes the important role of human milk oligosaccharides in establishing a healthy gut in an infant.
In this clip, Dr. David Sinclair elaborates on his Informational Theory of Aging.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with NAD+ boosters.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol and NAD+ boosters.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair describes his personal sleep habits for optimal performance during his workday.
In this clip, Dr. Rhonda Patrick describes her personal experience with sleep deprivation and her subsequent altered metabolism.
In this clip, Dr. David Sinclair describes his personal resveratrol and nicotinamide mononucleotide supplementation habits.
In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the current state of research on nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the stability issues encountered with nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the current state of research on the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair describes research demonstrating the beneficial effects of resveratrol on the cardiovascular system of monkeys.
In this clip, Dr. David Sinclair describes how plant-based compounds activate cellular protective mechanisms in humans.
In this clip, Dr. David Sinclair describes the NAD+ salvage pathway and how boosting cellular NAD+ levels may be beneficial in slowing aging.
In this clip, Dr. Rhonda Patrick describes a study in which stem cell-derived retinal cells were used to treat macular degeneration in a human.
In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenetic clock.
In this clip, Dr. David Sinclair describes how epigenomic modifications can influence how an organism ages, potentially reversing years of age-related damage.
In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age.
In this clip, Dr. David Sinclair describes the links between NAD+, sirtuins, and resveratrol in the aging process.
In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.
In this clip, Dr. David Sinclair describes how sirtuins, caloric restriction, fasting, and the insulin-IGF-1 pathway converge to modulate aging and lifespan.
Dr. David Sinclair describes key breakthroughs in aging research and the distinctive relationships between researchers and study organisms.
In this clip, Dr. Valter Longo describes the origins of the fasting-mimicking diet and explains how it enhances chemotherapeutic treatments.
In this clip, Dr. Roland Griffiths describes the current state of research on psychedelic drugs.
In this clip, Dr. Charles Raison describes the complex relationship between inflammation and depression.
Dr. Roland Griffiths discusses potential therapeutic uses of psilocybin, the challenges of FDA approval, and associated risks.
In this clip, Dr. Valter Longo describes the IGF-1 pathway and explains how defects in the pathway influence disease risk.
In this clip, Dr. Roland Griffiths describes the current state of research on long-term meditation and the role psilocybin plays in that research.
Dr. Roland Griffiths discusses psychedelics' reorganizational effects on the brain and their potential role in treating mental disorders.
In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the sociocultural aspects of hallucinogenic substance use.
In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the effects of meditation on gene expression.
Dr. Roland Griffiths discusses how psilocybin and meditation similarly affect the brain and may help treat depression.
Dr. Rhonda Patrick describes how sauna use activates the Salvinorin A pathway and may ease depression and opioid-addiction symptoms.
In this clip, Dr. Roland Griffiths describes new findings that suggest psilocybin may be useful in managing the symptoms of treatment-resistant depression.
Dr. Valter Longo defines the different fasting modalities, and compares and contrasts the variations of each in duration and degree of restrictiveness.
Dr. Valter Longo explains how certain macronutrients influence the insulin/IGF-1/growth hormone axis to modulate aging in many cell types.
Dr. Valter Longo discusses how the fasting-mimicking diet nourishes patients while still activating some of the same metabolic responses as a water-only fast.
Dr. Valter Longo describes how fasting and the ketogenic diet used together with the standard of care treatment may help treat aggressive cancers.
Dr. Valter Longo explains why clinical trials of the fasting-mimicking diet in combination with standard cancer treatments have been slow to progress.
Dr. Longo describes the promising research that suggests that one's risk for diseases over the next 10 years may be drastically reduced.
Dr. Valter Longo discusses how the fasting-mimicking diet is one of the few dietary interventions that can increase relative lean body mass.
Dr. Longo discusses research indicating that the fasting-mimicking diet may hold promise for autoimmune diseases, especially multiple sclerosis.
Dr. Valter Longo describes the pivotal role that IGF-1 plays in the proliferation of stem cells and the importance of consuming sufficient protein.
Dr. Valter Longo highlights which biomarkers, both currently available and forthcoming, that he considers relevant when assessing longevity and biological age.
Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.
Dr. Valter Longo explains how frequently the fasting-mimicking diet can be practiced and his hope that it may support sustained weight loss.
Dr. Valter Longo discusses his new book "The Longevity Diet" and how his fasting-mimicking diet can treat or prevent several age-related diseases.
Dr. Charles Raison discusses his belief that ancient practices are more likely than modern pharmacology to encourage resilience and stave off depression.
Dr. Charles Raison explains how agents that interact with the immune system may play a subtle and complex role in depression.
Dr. Charles Raison discusses how a pro-inflammatory environment, such as that which occurs with obesity, can contribute to the risk of depression.
Dr. Charles Raison describes the convergence of data that is directing scientists to uncover the connection that exists between inflammation and depression.
Dr. Charles Raison describes the Wild 5 trackable wellness intervention and how it may be incorporated into the treatment of depression.
Dr. Charles Raison discusses how exposure to light during the day and maintaining a dark environment at night, is important in depression management.
Dr. Charles Raison describes how changes in time zones or sleep/wake patterns can be a stressor for individuals with bipolar disorder.
Dr. Charles Raison and Dr. Rhonda Patrick discuss the potential benefits of meditation and running to improve mood.
Dr. Charles Raison describes how the body has evolved to employ some of the same physiological mechanisms in depression and physical illnesses.
Dr. Charles Raison discusses adaptations that offset eating-related risks, including inflammation and hyperthermia's antibiotic effects.
Whole-body hyperthermia as a treatment for depression: sauna, hot yoga and exercise | Charles Raison
Dr. Charles Raison describes how whole-body hyperthermia has the potential for real-world clinical efficacy as a tool in the fight against major depression.
How the benefits of exercise can be blocked by NSAIDs and high dose supplementation of antioxidants.
Dr. Charles Raison explains that taking non-steroidal anti-inflammatory agents or high dose antioxidants may block some of the benefits of exercise.
Dr. Charles Raison explains thermoregulatory dysfunction and how periodic high-heat exposure may help treat depression and schizophrenia.
Dr. Charles Raison highlights how ancient practices such as heat exposure, long-distance running and fasting may promote well-being in the modern world.
Dr. Charles Raison discusses whether psychedelic substances such as psilocybin, which induce transcendent states, may help treat depression.
Dr. Elissa Epel discusses supplementation concerns and research linking healthy lifestyle behaviors to preserving telomere length.
Dr. Elissa Epel identifies several biohacks that show promise as strategies to reduce stress and lengthen telomeres.
Dr. Rhonda Patrick describes the effects of endogenous ketones on fat metabolism during a fast.
Dr. Rhonda Patrick provides advice on how to break a fast.
Dr. Rhonda Patrick discusses when electrolyte replenishment might be necessary.
Dr. Rhonda Patrick explains aging-related pathways' dual nature and how exercise can shift the balance toward their benefits.
Fasting before exercise and the effect on endurance, aerobic, and strength training | Rhonda Patrick
Dr. Rhonda Patrick discusses the circumstances under which eating prior to exercise is beneficial versus detrimental.
Dr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each.
Dr. Rhonda Patrick discusses the pros and cons of consuming black coffee and amino acids during fasting.
Dr. Jari Laukkanen discusses the benefits and risks associated with cold water immersion following sauna use.
Drs. Rhonda Patrick and Jari Laukkanen discuss the benefits of sauna use in terms of cardiorespiratory fitness and mood.
Drs. Rhonda Patrick and Jari Laukkanen discuss the advantages of sauna use post-exercise.
Dr. Rhonda Patrick describes the role that heat shock proteins play in reducing the risk of disease.
Dr. Jari Laukkanen discusses the optimal temperature and amount of time for sauna use to obtain the greatest health benefits.
Dr. Jari Laukkanen describes some of the mechanisms that drive healthy blood pressure among men who use the sauna regularly.
Drs. Rhonda Patrick and Jari Laukkanen discuss findings from a study linking sauna use and lower risk of death from cardiovascular disease.
Dr. Eric Verdin describes the liver's functions and proposes that the ketogenic diet does not put any undue stress on the liver.
Dr. Eric Verdin discusses several ways in which NAD+ supplementation can benefit mitochondrial health and play a protective role against aging.
Dr. Eric Verdin explains how nicotinamide adenine dinucleotide levels diminish with age along with the ongoing research to understand the reasons why.
Dr. Eric Verdin describes the emerging field of biomarkers of aging and the diverse strategies, including artificial intellegence, that are being employed.
Dr. Eric Verdin discusses the idea that increasing protein levels too high while on a ketogenic diet may have adverse health effects.
Dr. Eric Verdin describes how supplementing with exogenous ketone esters may confer some of the beneficial effects of the ketogenic diet.
Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.
Dr. Eric Verdin explains how a cyclic or the portion-controlled ketogenic diet is linked to improvements in lifespan and memory in mice.
Dr. Eric Verdin discusses how fasting and fasting-mimicking diets may influence healthspan and lifespan, including potential mechanisms.
Dr. Eric Verdin explains the importance of the insulin signaling pathway in aging and highlights both animal and human research in this area.
Dr. Eric Verdin explains how exercise and nutrition form the cornerstone of strategies to slow aging, but exciting approaches are ahead.
Dr. Valter Longo discusses the longevity-conferring effects of diminishing the pro-aging IGF-1 pathway.
Dr. Valter Longo discusses how autophagy may function in both normal and cancer cells.
Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.
Dr. Valter Longo discusses the fasting-mimicking diet's origins and a shift beyond drug-centered care that lets the body heal itself.
Dr. Valter Longo describes how fasting may reduce the toxicity of chemotherapeutic drugs while also maximizing their impact in the treatment of cancer.
Reversing immunosenescence — lymphocytes return to youthful levels after fasting (adaptive immunity)
Dr. Valter Longo describes how fasting promotes the immune system to return to a more youthful profile.
Fasting mimicking diet treatment for multiple sclerosis (remyelinating axons & halting autoimmunity)
Dr. Valter Longo describes how the fasting-mimicking diet can be beneficial in the treatment of various diseases, including multiple sclerosis.
Dr. Valter Longo explains how fatty acid usage by cancer cells weakens them and makes them more susceptible to immune system clearance.
Dr. Valter Longo describes how a fasting-mimicking diet can be used for fat loss while preserving lean muscle mass.
Dr. Valter Longo explains the difference between caloric restriction and periodic fasting and highlights the importance of refeeding after a fast.
Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.
Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, resetting our biological systems to a more youthful state.
Dr. Valter Longo describes how prolonged fasting and subsequent refeeding, sends signals to the body to systematically shrink and rebuild organ systems.
Dr. Valter Longo explains the benefits of a prolonged fast.
Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.
Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation
Dr. Guido Kroemer describes mitophagy, a cellular signal for mitochondrial biogenesis, and a key player in other physiological processes.
Dr. Guido Kroemer describes the cellular process of autophagy and what factors trigger its activation.
Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes.
Dr. Guido Kroemer describes how fasting associated with sickness behavior is critical to surviving infection.
Dr. Guido Kroemer describes the complex relationship that exists between cancer cells, the immune system, and autophagy.
Dr. Guido Kroemer discusses changes that occur within cells that signal the need to induce autophagy.
Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.
Dr. Guido Kroemer describes the interplay between protein deacetylation and autophagy.
Dr. Guido Kroemer describes how intermittent fasting recapitulates the life-extension benefits of caloric restriction without some of the drawbacks.
Dr. Guido Kroemer discusses the autophagy-inducing qualities of coffee.
Dr. Guido Kroemer describes the autophagy-inducing behaviors he practices as part of his healthy lifestyle.
Dr. Guido Kroemer describes the autophagy-inducing effects of calorie restriction mimetics such as spermidine and resveratrol.
Dr. Guido Kroemer describes the spectacular biological phenomenon known as autophagy.
Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.
Dr. Satchin Panda describes the beneficial effects of time-restricted feeding in mice in terms of mitochondrial health.
Dr. Satchin Panda explains the role of the suprachiasmatic nucleus – the body's master clock – and how it affects metabolism.
Dr. Satchin Panda describes CLOCK's varied response to light and food and how those responses affect metabolism.
In this clip, Dr. Satchin Panda describes how lifestyle factors influence the risk of heart arrhythmias.
In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.
Dr. Satchin Panda describes how the body's circadian clocks developed and the role they play in regulating our day-to-day functioning.
Dr. Rhonda Patrick describes how bright light exposure drives cortisol release.
Dr. Satchin Panda describes how time-restricted eating lessens the symptoms of acid reflux in people who practice time-restricted eating.
In this clip, Dr. Satchin Panda describes experiments in which time-restricted eating protected mice from the harms of an obesogenic diet.
Dr. Satchin Panda discusses challenges in studying shift work and how time-restricted eating may benefit shift workers.
Dr. Satchin Panda explains the ideas behind MyCircadianClock and how it is helping the research surrounding time-restricted eating.
Circadian rhythm of gut microbiome & the impact of time-restricted eating on gut bacterial diversity
Dr. Satchin Panda describes how the body's circadian clocks mature and recommends when children can begin time-restricted eating.
Dr. Satchin Panda describes how circadian rhythms influence DNA damage and repair, especially in the setting of time-restricted eating
Dr. Satchin Panda explains food's physiological effects and why eating less often during time-restricted eating may offer greater benefits.
Dr. Satchin Panda describes his take on what "healthy" means from a circadian perspective and how time-restricted eating plays a part.
Dr. Satchin Panda describes recent research that links melatonin to metabolism and explains how time-restricted eating can capitalize on this link.
Dr. Satchin Panda describes the role fasting plays in maintaining a healthy gut and reducing systemic inflammation.
Dr. Satchin Panda discusses the limited data available today regarding dietary supplement usage, exercise, and time-restricted eating.
Dr. Satchin Panda quells concerns that toothpaste might start the circadian clock.
Dr. Satchin Panda describes how autophagy, as part of the body's response to time-restricted eating, benefits health on a daily basis.
Evidence for time-restricted eating in humans — heart health and improved biomarkers | Satchin Panda
Dr. Satchin Panda describes the state of the science with regard to understanding the beneficial effects of time-restricted eating in humans.
Dr. Satchin Panda explains how time-restricted eating realigns the primordial rhythms of our physiology, allowing us to repair and rejuvenate our bodies.
Dr. Satchin Panda discusses when to break a fast and describes how time-restricted eating can be a healthy lifestyle behavior for nearly everyone.
Dr. Satchin Panda discusses the controversy surrounding consumption of black coffee or tea while practicing time-restricted eating.
Dr. Dale Bredesen identifies the defining characteristics of Alzheimer’s disease and enumerates its known subtypes.
Dr. Dale Bredesen describes the risks associated with APOE4 and identifies strategies for mitigating that risk.
Dr. Dale Bredesen discusses identifying factors that affect Alzheimer's risk and strategies to mitigate that risk.
Dr. Dale Bredesen describes the role that zinc status plays in the development of the toxic form of Alzheimer's disease.
Dr. Dale Bredesen describes his novel dietary protocol, the Ketoflex 12/3, and how it improves cognitive function.
Dr. Dale Bredesen describes the links between pathogen exposure and Alzheimer's disease.
Dr. Dale Bredesen describes how sauna use is now being used as a means to reduce the body's overall toxic burden.
Dr. Dale Bredesen discusses the potential brain-health benefits associated with a ketogenic diet.
Dr. Matthew Walker describes how studies in rats and humans demonstrate that the brain "replays" events and experiences to facilitate learning.
Dr. Matthew Walker describes how sleep impairs the opposing actions of the amygdala and prefrontal cortex to influence mood and mental health.
Dr. Matthew Walker describes how sound and smell cues played during learning and subsequent sleep can enhance memory formation and retrieval.
Dr. Matthew Walker explains how altering light-dark schedules can improve health outcomes in older adults and babies.
Dr. Matthew Walker talks about the importance of identifying early-life windows of vulnerability to prevent or delay age-related cognitive decline.
Dr. Matthew Walker describes how napping facilitates and reinforces learning in infants.
Dr. Matthew Walker describes how REM sleep facilitates creativity, new ideas, and wisdom.
Dr. Matthew Walker describes how sleep deprivation promotes a kind of "viral" loneliness.
Dr. Matthew Walker describes the deleterious effects that poor sleep has on the immune system.
Dr. Matthew Walker discusses the risks of sleeping pills and the benefits of cognitive behavioral therapy for insomnia as an alternative.
Dr. Matthew Walker describes the four essential pillars of sleep.
Dr. Matthew Walker describes how sleep deprivation drives a preferential desire for high carbohydrate foods.
Dr. Matthew Walker discusses the role that sleep plays in modulating the gut microbiome.
Dr. Matthew Walker describes the role that sleep plays in learning and new memory formation.
Dr. Matthew Walker posits his theory that dreams are not forgotten; rather, they are merely inaccessible and may influence our wakeful state.
Dr. Matthew Walker discusses how anxiety affects sleep and identifies ways to manage that stress to improve sleep.
Dr. Matthew Walker explains how sleep and sauna may induce sleep through their short-term pro-inflammatory effects.
Dr. Matthew Walker describes the negative effects of blue light exposure on melatonin production and sleep.
Dr. Matthew Walker explains how sleep deprivation impairs glucose metabolism, increasing the risk of diabetes and metabolic dysfunction.
Dr. Matthew Walker describes the dual risk of carrying the APOE4 allele and having sleep apnea.
Dr. Matthew Walker describes the different chronotypes and the risks associated with adopting a sleep pattern that is contrary to our natural type.
Dr. Matthew Walker describes the role that sleep plays in modulating the accumulation of amyloid-beta accumulation in the brain.
Dr. Matthew Walker describes critical factors that influence healthy sleep patterns, including the intake of caffeine, alcohol, and other substances.
Dr. Matthew Walker describes how the different stages of sleep influence emotional and cardiovascular health.
Sleeping pills correlated with increased cancer risk and decreased brain plasticity | Matthew Walker
Dr. Matthew Walker discusses the harmful effects of sleeping pills on learning and memory formation.
Dr. Matthew Walker describes the role of temperature in augmenting sleep.
Dr. Matthew Walker explains how altering the timing and duration of daytime light exposure influences sleep.
Dr. Ruth Patterson describes how obesity - along with the growth factors estrogen and insulin - affect the risk of breast cancer development and recurrence.
Dr. Ruth Patterson discusses how skipping breakfast and eating late into the evening may contribute to worse metabolic health.
Dr. Ruth Patterson discusses how simply changing when one eats can have a profound effect on the risk of breast cancer recurrence.
Dr. Ruth Patterson describes the advantages of an earlier eating window on inflammation and blood glucose control.
In this clip, Dr. Ruth Patterson discusses the effect that meal frequency has on breast cancer risk.
In this clip, Dr. Ruth Patterson discusses how eating in accordance with the body's natural circadian rhythm may reduce the risk of breast cancer.
Dr. Ruth Patterson describes how eating following the body's circadian clock enables the body to focus on repair rather than on digestion.
Dr. Ruth Patterson discusses how healthful choices, including modest weight loss, may lower breast-cancer risk and the risk of other diseases.
Dr. Ruth Patterson discusses the beneficial effects that time-restricted eating can have on the biomarkers of health - independent of weight loss.
Non-pharmaceutical approach to lowering hemoglobin A1c using time-restricted eating | Ruth Patterson
Dr. Patterson explains how a lifestyle approach - an altered eating window - can be an effective way to reduce blood sugar levels.
Dr. Elissa Epel describes how pre-pregnancy parental health impacts offspring.
Dr. Elissa Epel describes the effects of longer sperm telomere length on subsequent generations.
Dr. Rhonda Patrick and Dr. Elissa Epel describe the factors that influence how we respond to diet.
Dr. Elissa Epel describes how even small lifestyle changes can have an effect on telomere length and healthy aging to compress morbidity.
Dr. Rhonda Patrick and Dr. Elissa Epel discuss how obesity affects genes in sperm DNA involved in metabolic health and cognitive function.
Dr. Elissa Epel discusses the pros and cons associated with taking dietary supplements to lengthen telomeres.
Dr. Elissa Epel discusses how cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal.
Dr. Elissa Epel discusses the harmful effects of what she calls a "toxic lifestyle," one that includes the consumption of sugar-sweetened beverages.
Dr. Elissa Epel describes some of the studies that demonstrate the links between healthy lifestyle behaviors like exercise and discusses potential mechanisms.
Dr. Elissa Epel describes the "low hanging fruit" – small, healthy lifestyle behaviors – that can have positive effects on telomere length and lifespan.
Dr. Elissa Epel identifies some of the key differences in male and female biology and how they influence telomere length and aging.
Dr. Elissa Epel gives a brief overview of telomeres and the enzyme telomerase and explains how they impact health and lifespan.
Dr. Elissa Epel discusses the importance of having an optimal ratio of telomerase to reduce the risk of chronic diseases and cancer.
Dr. Elissa Epel explains how aging syndromes can be passed to offspring via epigenetic mechanisms.
Dr. Elissa Epel describes how Mendelian randomization techniques provide insights into the dual nature of telomeres, as both a cause and a sign of aging.
Dr. Elissa Epel describes the exposome – the totality of non-genetic exposures a person experiences during a lifetime – and explains how it affects telomeres.
Dr. Elissa Epel describes how toxic stress modulates telomere length.
Dr. Elissa Epel describes the beneficial effects of education on telomere length in the babies of low-income women.
Dr. Elissa Epel describes the non-linear effects of exercise on telomere length.
Dr. Bruce Ames discusses the CHORI Bar, a micronutrient- and fiber-dense nutrition bar developed in the Ames laboratory to manage obesity.