IGF-1 plays a key role in the regenerative processes activated by prolonged fasting | Valter Longo

Parent Episode: Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

Insulin-like growth factor 1 (IGF-1) promotes the growth of existing cancer cells and contributes to aging, but also has some beneficial functions. IGF-1 is required for the growth and repair of muscles and is also necessary for producing new brain cells. During fasting, IGF-1 levels decrease and then increase upon refeeding. It is during the refeeding phase of elevated IGF-1 levels where regeneration occurs. Caloric restriction alone results in reduced IGF-1 levels and thus does not produce rejuvenating effects. In this clip, Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $15 / month
  • Loyal Fan

    $25 / month
  • Super Fan

    $50 / month
  • Power Supporter

    $125 / month
  • Heroic Supporter

    $250 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.