IGF-1 plays a key role in the regenerative processes activated by prolonged fasting | Valter Longo

Parent Episode: Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

Insulin-like growth factor 1 (IGF-1) promotes the growth of existing cancer cells and contributes to aging, but also has some beneficial functions. IGF-1 is required for the growth and repair of muscles and is also necessary for producing new brain cells. During fasting, IGF-1 levels decrease and then increase upon refeeding. It is during the refeeding phase of elevated IGF-1 levels where regeneration occurs. Caloric restriction alone results in reduced IGF-1 levels and thus does not produce rejuvenating effects. In this clip, Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.

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