Resveratrol and NAD+ boosters exert beneficial effects in Alzheimer's disease & vascular dementia | David Sinclair

Parent Episode: Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Resveratrol, a plant-based compound found in red grapes and peanuts, exerts beneficial effects on the human brain. Clinical trials have unearthed evidence that is suggestive of the possibility that amyloid-beta build-up in the brain may be being attenuated, as well as an improvement in cognitive function in people with Alzheimer’s disease. One of the mechanisms associated with resveratrol's actions is the activation of autophagy, a cellular defense program that targets old, damaged proteins for destruction and recycling. Other molecules – nicotinamide riboside and nicotinamide mononucleotide, known as NAD+ boosters – have similar beneficial effects on the brain, especially in the setting of vascular dementia. These boosters enhance cerebral blood flow, mimicking exercise and promoting regrowth of the aging cerebral vascular system. In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol and NAD+ boosters.

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