Resveratrol: dosage considerations and effect on cardiovascular health | David Sinclair

Parent Episode: Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Over the past few decades, an abundance of scientific research has focused on resveratrol, a plant-based compound found in red grapes and peanuts. Much of this research has demonstrated that, at high doses, resveratrol exerts beneficial health effects – especially on the cardiovascular system – and has been shown to ameliorate the deleterious effects of an obesogenic diet in monkeys. Resveratrol is a "dirty molecule," however, known for its multiple cellular targets, so teasing out all the ramifications of its use has proven problematic. Furthermore, it is relatively unstable and demonstrates poor bioavailability in humans. In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

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