Related Episodes for Timing metformin to avoid negative effects on exercise adaptation: plausibility | Rhonda Patrick

“A meta-analysis restricted to direct regional measures from MRI, CT, or ultrasound found a very small average hypertrophy benefit when creatine was combined with resistance training, with uncertainty around the pooled estimate and variation across sites and populations.”

“Longer endurance aerobic exercise seems to be most effective at producing higher levels of FGF21, coinciding with anecdotes you might have heard from runners who have successfully used exercise in this sort of way. Relevant publications Flippo, Kyle H., et al.”

“The body perceives these interventions as stressors and then adapts, ultimately developing metabolic flexibility. Dr. D'Agostino proposes that metabolic interventions, such as restricting calories and entering ketosis, for example, may provide additional benefits when practiced cyclically.”