Search results for insulin

“Dr. Attia describes the hyperinsulinemic-euglycemic clamp as a controlled method for measuring insulin sensitivity. Randomized sleep-restriction studies support a direct effect of inadequate sleep on insulin action, though the size of the effect depends on the population and protocol.”

“Sleep is critical to human survival. Sleep deprivation has marked effects on glucose metabolism. Even a single night of partial sleep deprivation can induce insulin resistance and raise blood glucose levels. In this clip, Dr. Rhonda Patrick describes her personal experience with sleep deprivation and her subsequent altered metabolism.”

“A healthy immune system allows the body to fight bacterial and viral infections, as well as aberrant cells, which, left unchecked can progress to cancer. Insulin-like growth factor 1 (IGF-1) has some beneficial functions but is also known to promote the growth of existing cancer cells.”

“However, several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity. For example, studies that have shown that reductions in sleep duration over multiple nights result in impaired glucose tolerance and insulin resistance in healthy individuals.”

“The triglyceride-to-HDL cholesterol ratio combines two routine lipid values and can serve as a practical signal of insulin resistance and atherogenic dyslipidemia. Prospective studies have associated a higher ratio with coronary and cardiovascular mortality in men and with all-cause mortality in women evaluated for ischemia.”

“Contracting skeletal muscle increases glucose uptake by moving GLUT4 transporters toward the cell surface through pathways that are partly independent of insulin. This gives active muscle another way to clear glucose during and after exercise, and the effect can continue for hours after the session.”

“They observed that people who carried a variant form of the melatonin receptor gene (MTNR1B) were more likely to have obesity or diabetes. The prevailing thought is that when melatonin is bound to its receptor, it suppresses the pancreas from producing insulin.”

“Similar in molecular structure to insulin, IGF-1 (insulin-like growth factor 1) has been implicated in the aging process. Protein intake increases IGF-1 levels in humans, independent of total caloric consumption.”

“Recent human studies indicate that the fewer carbohydrates one eats, the lower the risk of death from all causes. In this clip, Dr. Eric Verdin explains the importance of the insulin signaling pathway in aging and highlights both animal and human research in this area.”

“A growing body of scientific evidence suggests that there is a correlation between Alzheimer's disease, insulin resistance, and inflammation. Inflammation, a downstream consequence of insulin resistance, promotes the formation of reactive oxygen species and other damaging molecules, which can enter the brain via the lymphatic system.”