Small trial found that plasma infusions from young donors improved capacity to perform basic tasks essential to independent daily life in Alzheimer's.
“The trial was based on animal studies which showed that factors in the blood of young mice can rejuvenate the brain tissue and improve cognitive performance in old mice. This was a very small trial, just 18 participants, and larger studies are needed to confirm these results before conclusions about efficacy can be made.”
Episode
What Microplastics Are Doing to the Brain, Body, and Reproductive Systems
“Brain: Microplastics have been found to cross the blood-brain barrier, which is meant to shield the brain from harmful substances. Once there, they activate microglial cells, triggering neuroinflammation that may contribute to diseases like Alzheimer’s and Parkinson’s.”
A high salt diet promotes the formation of tau tangles and associated cognitive impairment.
“The formation of tau tangles is an early event in the pathogenesis of several neurodegenerative disorders, including Parkinson’s disease and Alzheimer’s disease. The authors of the study fed mice either a normal diet or a high salt diet for four to 36 weeks.”
Episode
Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
“It is the primary risk factor for many chronic diseases in humans, including cancer, Alzheimer's disease, and cardiovascular disease. But people age at different rates – an ostensibly random (and unjust) phenomenon observed across sexes, ethnic groups, and races.”
High phenolic olive oil consumption improves cognitive function in adults with mild cognitive impairment.
“Some participants also consented to have their DNA sequenced for the presence of the APOE4 gene. Having one copy of the APOE4 gene increases Alzheimer's disease risk as much as threefold; carrying two APOE4 copies increases risk as much as fifteenfold.”
COVID-19 may increase a person's risk for neurodegenerative disease.
“These findings suggest that the heparin-binding site on the spike protein facilitates the subsequent binding to amyloid proteins, potentially leading to neurodegeneration in the brain. Learn more about risk factors that drive Alzheimer's disease, a type of neurodegenerative disease, in this episode featuring Dr. Dale Bredesen.”
Oleic acid produced by cells in the brain (and found in olive oil) may be a key cell proliferation and neurogenesis signal
“The neurons in the hippocampus are particularly vulnerable to amyloid-beta plaque accumulation, tau tangle formation, and subsequent atrophy – early indicators of Alzheimer’s disease.”
Episode
Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
“Mitophagy ultimately serves as a trigger for mitochondrial biogenesis, the process by which new mitochondria are produced. Failures in mitophagy are associated with several chronic diseases, including cardiovascular disease, kidney disease, and Alzheimer’s disease.”
Episode
The Science of Magnesium and Its Role in Aging and Disease | Dr. Rhonda Patrick
“When these processes are compromised due to insignificant magnesium, cancer-causing mutations can develop. Magnesium's role in DNA repair and its antioxidant properties suggest a protective effect against age-related diseases, including cancer.”
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