Search results for insulin

“INSL3, or insulin-like peptide 3, is produced in the Leydig cells of the testes and, to a lesser degree, the theca cells of the ovaries. Although it plays important roles in male reproductive maturation and health, evidence suggests it affects other aspects of human health, including bone and muscle physiology, brain function, and others.”

“A growing body of evidence links excess body fat to an increased risk for Alzheimer's disease, likely due to several factors, including heightened inflammation, insulin resistance, and elevated levels of amyloid-beta (a pathological hallmark of the disease) in fat tissue.”

“Researchers recruited 34 overweight middle-aged adults with insulin resistance who reported mild cognitive decline. Half of the participants consumed a strawberry powder supplement daily for 12 weeks, while the other half consumed a placebo.”

“Accelerated PhenoAge was linked with higher inflammatory biomarkers (such as C-reactive protein), higher insulin, higher glucose, higher triglycerides, and lower HDL. The DNA methylation PhenoAge acceleration was also linked to known age-related changes in blood cells, such as decreased populations of CD4 and CD8 T-cells and increased granulocytes.”

“The downstream consequences of this cascade could blunt the beneficial training adaptations that reactive oxygen species might induce, such as increased mitochondrial number and function, improved insulin sensitivity and glucose utilization, and enhanced immune function, among others.”

“These mice gained weight, developed high insulin levels, and were intolerant of cold temperatures. Men who had higher expression of the B and C variants consumed more oxygen and had less body fat, even among those with type 2 diabetes.”

“Commonly referred to as the "carbohydrate-insulin" model of obesity, this new paradigm reverses causation and provides a starting point for developing testable hypotheses. The concepts presented in this report suggest that what a person eats, rather than how much, plays key roles in body weight management.”

“The authors also observed increased levels of the transcription factor PGC-1α, and the hormones insulin, leptin, and noradrenaline, which they suggest may benefit skeletal muscle and mitochondrial function, providing a competitive advantage during training or recovery.”

“The average body mass index among the participants was 28, which is considered overweight. Their steady-state blood glucose levels ranged from 86 to 220 milligrams per deciliter, suggesting a wide range of insulin resistance, from very low to very high.”

“They also assessed continuous blood glucose profiles in world-class endurance athletes. They found that after the week with the highest exercise load, the participants' mitochondrial function had declined markedly, impairing their glucose tolerance and insulin secretion.”