Search results for bdnf

“After exercise, BDNF levels increased by 42% and TrkB levels by 44% in the older group, indicating a robust biological response to activity despite age. Verbal memory improved by 15% in both groups, while nonverbal memory remained unchanged.”

“Intriguingly, proBDNF and BDNF encourage different actions; BDNF promotes the differentiation of new neurons and their constituent parts (axons, dendrites and synapses), and proBDNF the pruning of synapses -- a process that occurs particularly in the early stages of life.”

“The authors of the study analyzed BDNF levels and their relationship to adduct formation and developmental outcomes in the two cohorts. They collected umbilical cord blood and maternal blood samples and measured the amount of DNA adducts in the samples.”

“To their surprise, they found cells producing BDNF in a part of the brain's hypothalamus called the paraventricular nucleus. > "We knew that in embryonic development, some blood cells do go to the brain and become microglial cells," said Chan.”

“When we engage in high-intensity exercise, our muscles become mini biochemical laboratories, synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) in the brain.”

“> "In this series of studies, we have shown that BDNF targets the cortical cells themselves, preventing their death, stimulating their function, and improving learning and memory. Thus, BDNF treatment can potentially provide long-lasting protection by slowing, or even stopping disease progression in the cortical regions that receive treatment."”

“Autopsies were conducted on their brains after death, and the amount of protein from BDNF gene expression in the brain was then measured. [...] > The rate of cognitive decline was about 50 percent slower for those in the highest 10 percent of protein from BDNF gene expression compared to the lowest 10 percent.”

“This study also found that more intense and longer duration (40 min.) aerobic exercise increased the probability of an individual subject achieving a significant BDNF increase and in the integral (i.e. the volume of circulating BDNF).”

“Other studies have shown that regardless of mood state, bipolar disorder patients present reduced levels of BDNF. Overall, changes in BDNF levels seem to be a characteristic found in bipolar disorder patients that may contribute to the pathophysiology of the disease.”

“From the article: > Serum BDNF levels were lower in bipolar disorder patients during both manic and depressive episodes, as compared with euthymic patients and healthy controls. This finding suggests that the effects of pharmacological treatment on BDNF levels may be associated with mood stabilization.”