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“Since then, countless studies have tested Pauling's theories about vitamin C, colds, and cancer (and many others), and a substantial body of evidence has emerged, identifying critical roles for vitamin C in immune function, cardiovascular and respiratory health, cognitive development and preservation, and many other aspects of human health.”

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“Nutritional status plays a critical role in aging. Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging. In this clip, Dr. Steve Horvath describes evidence suggesting that supplemental vitamin D or omega-3 fatty acids slow epigenetic aging.”

“DNA-methylation clocks use patterns in blood or other tissues to estimate aspects of biological aging. In this clip from Dr. Rhonda Patrick's presentation at Natural Products Expo West, she discusses how omega-3 fatty acids may influence these research biomarkers.”

“In a controlled five-week crossover trial involving men with prediabetes, an early six-hour eating window with dinner before 3 p.m. improved insulin sensitivity, pancreatic beta-cell responsiveness, blood pressure, oxidative stress, and appetite without causing weight loss.”

“A separate cohort of 12,388 adults associated vitamin D exposure with 40 percent lower dementia incidence, and a 12-month randomized trial of 183 older adults with mild cognitive impairment found improvements on several cognitive tests with 800 IU per day.”