Related Episodes for Dr. George Church: Rewriting Genomes to Eradicate Disease and Aging

“Lutein and zeaxanthin also have evidence in age-related eye disease, although the AREDS2 trial did not find an additional reduction in progression to advanced macular degeneration in its primary comparison. Magnesium and creatine address different needs.”

“Even if mRNA could enter the nucleus, two other enzymes are missing to transform RNA into DNA and insert it into the human genome. Thus, the series of steps that would result in mRNA incorporating into nuclear DNA is biologically implausible.”

“Longer endurance aerobic exercise seems to be most effective at producing higher levels of FGF21, coinciding with anecdotes you might have heard from runners who have successfully used exercise in this sort of way. Relevant publications Flippo, Kyle H., et al.”

“A meta-analysis of 49 resistance-training studies found small additional gains from protein supplementation, with fat-free-mass gains leveling near 1.6 grams per kilogram per day in the studied populations.”