Related Episodes for Gut health’s important role in regulating inflammation | Peter Attia

“Early biomarkers of vascular dysfunction, such as soluble platelet-derived growth factor receptor-beta (sPDGFR-β), can help identify individuals at risk for developing Alzheimer's disease. These biomarkers are being validated on high-throughput platforms for large-scale testing.”

“While sanitation and clean drinking water are critical to survival, the over sterilization of our environment may play a role in modulating the human immune system. In this clip, Dr. Charles Raison highlights how ancient practices such as heat exposure, long-distance running, and fasting may promote well-being in the modern world.”

“Because of alcohol’s effect on other organs and the evidence that any dose of alcohol appears to elevate cancer risk, Dr. Huberman thinks that zero to two drinks per week represents a “safe zone” as long as you’re of age, not pregnant, and not an alcoholic.”

“However, the ability to translate data from non-human animals to humans can be limited and the use of laboratory animals can raise ethical concerns. In this clip, Dr. George Church describes the pros and cons of animal research and how we could move beyond its use with advanced technologies.”

“The mechanisms that drive the effects of sauna bathing include activation of heat shock proteins and pro- and anti-inflammatory cytokines; decreased blood pressure and arterial stiffness; and multiple improvements in cardiovascular function.”

“Antibody-dependent enhancement (ADE) occurs when the immune system generates non-functional antibodies that bind to a pathogen, intensifying inflammation and tissue damage without neutralizing the pathogen.”

“Antibody-dependent enhancement, or ADE, is a phenomenon that occurs when low quality, low quantity, non-neutralizing antibodies bind to virus particles and, rather than neutralizing the virus, increase inflammation and tissue injury.”

“Consensus evidence supports ApoB as a causal risk factor, but Dr. Attia’s proposed 10–30 mg/dL physiological range and treatment targets are attributed opinions, not universal guideline targets. Diet can change ApoB through several pathways.”

“Approximately 25 percent of people in the United States – roughly 75 million people – carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Dr. Krauss explains how some people might be inappropriately prescribed statins while other people should be taking statins. In addition, his current research is investigating whether statins can increase the risk of diabetes, especially for women.”