Related Episodes for Lactate and ketone metabolism in context of brain energetics and lactate shuttle | Peter Attia

Dr. Rhonda Patrick discusses sunscreen safety, HIIT & brain health, diet, omega-3s, urolithin A, sulforaphane, homocysteine, peptides, and CoQ10.

“When most people think about certain lifestyle factors that affect insulin sensitivity and blood glucose levels, they think about macronutrient composition, or calories, or fasting, or exercise (and lack of), but they don’t often think about sleep.”

“Human trials suggest that alpha-lipoic acid can modestly improve selected lipid measures. A dose-response meta-analysis of 12 studies found reductions in total cholesterol, LDL cholesterol, and triglycerides across doses from 300 to 1,200 milligrams per day.”

“In contrast, a five-week trial in 181 people with diabetic polyneuropathy found that oral alpha-lipoic acid improved symptom scores, with more nausea, vomiting, and vertigo at higher doses. PQQ has a much smaller human evidence base.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“The trial found selected changes in antioxidant capacity, immune-cell apoptosis, and inflammatory gene expression, while several main circulating oxidative-stress measures did not differ from plain water. Clinical findings remain modest and depend on the population and outcome.”