Search results for dementia

“In this edition of The Aliquot, Dr. Axel Montagne and Dr. Rhonda Patrick discuss the ongoing research and potential biological processes that could shape the future of dementia prevention.”

“Supplement studies provide additional context. In a prospective cohort of 12,388 dementia-free older adults, recorded vitamin D supplement exposure was associated with 40 percent lower dementia incidence over 10 years.”

“This is not a universal prescription. During the first 20 years of the broader Finnish cohort, sauna temperatures of 100°C (212°F) or higher were associated with higher dementia risk than temperatures below 80°C. Timing can serve different goals.”

“These mechanisms vary with dose and nutrition and should not be generalized from alcohol-use disorder to light drinking. Dementia cohorts conflict. One cohort found moderate drinking associated with hippocampal atrophy without cognitive protection.”

“Dr. Axel Montagne is a chancellor's fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline.”

“Disruption of brain DHA transport via the MFSD2A transporter causes blood-brain barrier breakdown. Furthermore, where we lose pericytes - which are important for dementia prevention - overlaps with the loss of DHA transporters.”

“In a cohort of 12,388 older adults without dementia at baseline, vitamin D exposure was associated with a 40% lower rate of incident dementia over ten years. The association was stronger in women and in people without the APOE4 allele.”

“Illuminating the risks associated with inadequate sleep New research has identified associations between poor sleep and increased risk for Alzheimer's disease and related dementias. More than 2,800 older adults participated in the study.”

“Nicotinamide riboside and nicotinamide mononucleotide, molecules commonly referred to as NAD+ "boosters," exert beneficial effects on the brain, especially in the setting of vascular dementia.”