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Folate is central to DNA synthesis and genomic stability: it transfers single-carbon groups and helps produce thymine, while deficiency can increase nucleic-acid errors, DNA double-strand breaks, uracil misincorporation, and chromosome abnormalities. These findings provide a biological…

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Based on available source text from 9 of the first 10 results.

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Topic
Topic

Senescence

Jul 6, 2026

“Folate supplementation during pregnancy prevents an estimated 70 percent of neural tube defects, but additional therapies are needed. The following report explores the relationship between maternal diabetes and abnormal cell aging in the fetal nervous system in mice.”

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Science Digest

Mothers with highest folate levels had newborns with telomeres 10% longer & every 10ng/ml increase in folate was linked to 5.8% increase in telomeres.

May 6, 2016

“looking forward to (hopefully) doing a podcast with an expert on telomere research soon! Folate is required to make precursors for the DNA nucleotide, thymine, and for methyl groups, which play a role in epigenetics. Leafy greens are high in folate so eat your spinach!”

9
Science Digest

Folate deficiency leads to harmful chromosome abnormalities causing cells to inherit the incorrect amount of DNA and chromosome abnormalities.

Dec 14, 2018

“Folate deficiency leads to harmful chromosome abnormalities causing cells to inherit the incorrect amount of DNA and can even lead to the loss of an entire chromosome. Folate is high in dark leafy greens. Folate has long been known to be important for the production of new DNA because it is important for making a DNA nucleotide called thymine.”

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