Search results for meta

“For example, Mendelian randomization studies, which provide evidence of links between modifiable risk factors and disease based on genetic variants within a population, have found that not only are some people genetically predisposed to engage in more physical activity, but they are also less likely to suffer from depression.”

“At periodic intervals throughout the study, the authors measured the participants' cognitive function and performed positron emission tomography (PET) scans to check for the presence of amyloid-beta in the participants' brains.”

“Previous research has attempted to use amyloid-beta vaccines to stall or reverse the progression of Alzherimer’s disease; however, these trials failed to produce a vaccine that was effective and safe.”

“Sulforaphane demonstrated high affinity for BACE1 and had few off-target effects, suggesting that sulforaphane shows promise as a candidate to reduce the activity of BACE1, potentially playing a role in preventing Alzheimer's disease. Link to full study.”

“The NLRP3 inflammasome, in particular, triggers the release of the proinflammatory proteins interleukin (IL)-1 beta and IL-18 and drives pyroptosis, a form of cell death that is triggered by proinflammatory signals and closely linked with inflammation.”

“However, it's critical to note that meta-analyses consistently indicate that aerobic exercise is effective for improving insulin resistance in people with diabetes. Optimizing Meal Frequency and Timing The importance of diet composition in metabolic health is well accepted, but how often one eats (meal frequency) and when someone eats (meal timing) also play important roles.”

“The investigators posited that high blood glucose and insulin levels that occur in the setting of diabetes increase peripheral amyloid-beta production, altering the balance between brain and peripheral amyloid-beta levels and suppressing the protein’s efflux from the brain.”

“These findings suggest that viral infection plays a key role in Alzheimer's disease pathology and can inform future research on therapeutic strategies to mitigate the disease's effects. Link to full study. Watch this clip in which Dr. Dale Bredesen describes the links between exposure to pathogens such as viruses and bacteria and Alzheimer's disease.”

“Findings from a new study shed new light on this link, suggesting that events such as head trauma and stroke accelerate Alzheimer’s disease by activating one of the brain’s major immune cells and triggering an infection-like spread of amyloid-beta tangles to previously unaffected tissues.”

“Smoking or ingesting marijuana results in long-acting inhibition of interneurons by the herb's active chemical, tetrahydrocannabinol. That is vastly different from short-acting endocannabinoid bursts precisely timed to occur only when a signal is truly worthy of attention.”