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“The study combined animal models, human neurons grown from stem cells, and brain tissue collected after death from people with and without tau-related disorders, including Alzheimer's disease.”

“While it is good to generally keep inflammation at bay, part of the mechanism by which exercise exerts beneficial effects is by acutely generating inflammation which induces a hormetic response and activates many anti-inflammatory pathways that often stay active for a long period after the exercise resulting in a net positive anti-inflammatory response.”

“Eating a healthy diet, regular exercise (at least 30 minutes or more per day of moderate to vigorous exercise), maintaining a healthy body weight, not drinking too much alcohol (up to about one 5-ounce glass of wine per day for women, or up to two glasses for men), and not smoking during adulthood may add more than a decade to life expectancy.”

“Supplementation with the omega-3 EPA (4g/day) reduced cardiovascular-related death by 25% in people with high triglycerides on statins compared to those taking a placebo (randomized, double-blind, placebo-controlled trial in 8,179 people from around the world).”

“A mid-day nap at least 3x per week in children ages 10-12 was associated with a 7.6% increase in academic performance, elevated mood, improved self-control, and fewer behavioral problems.”

“> Additionally, the retinal cells of exercised mice were more responsive to light and had higher levels of a growth- and health-promoting protein called brain-derived neurotrophic factor (BDNF), which previous studies have linked to the beneficial effects of exercise.”

“Low carbohydrate and ketogenic diets are popular with adults looking to lose weight, but they also have therapeutic power for a growing list of diseases such as epilepsy, diabetes, Parkinson's disease, and some cancers.”

“The microbiome of participants with Alzheimer's disease differed from those without Alzheimer's disease at the phylum, order, and family levels (i.e., scientific categories used to organize microbes into groups using their genes), with higher levels of phyla Bacteroidetes and lower levels of the phyla Actinobacteria and Verrucomicrobia and family Ruminococcaceae.”

“Consistent with the effects of ascorbic acid on visceral obesity, ascorbic acid not only inhibited hepatic steatosis but also increased the mRNA levels of PPARα-dependent fatty acid β-oxidation genes in livers.”

“[...] > The current study used a similarly designed environment, with 15-20 mice housed in large containers equipped with running wheels, tunnels, huts, wood toys, a maze, and nesting material, in addition to unlimited food and water.”