Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health
“It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons. Emerging evidence suggests that IGF-1 also regulates the aging process. Overactivity of IGF-1 has been implicated in aging and age-related diseases, such as cancer.”
Episode
The Longevity & Brain Benefits of Vigorous Exercise
“Mitophagy: A signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation. Preventing brain aging with exercise — why to workout vigorously | Axel Montagne, Ph.D. Other related links: World Fitness Calculator – Provides an estimate of your VO2 max.”
Episode
Joe Rogan Experience #901 - Dr. Rhonda Patrick
“01:44:15 - The Steven Pressfield book, "The War of Art," which describes the resistance people experience regarding creativity. 01:47:10 - Nicotinamide riboside and nicotinamide mononucleotide (precursors of NAD and vitamin B3) delayed aging in animal models.”
Aliquot #137: How to Optimize Iron without Causing Overload
“In this Aliquot, I'll explore how to recognize and address iron deficiency, the unique challenges of iron overload in aging, the ways alcohol may influence brain iron, and how infants tightly regulate iron as a built-in defense against infection.”
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Which Supplements Do Children Actually Need?
“Recommended total intake is 400 IU per day during infancy and 600 IU after age one, with supplementation useful when fortified formula or foods do not provide enough or when a clinician identifies increased risk. Low-mercury seafood provides EPA and DHA directly.”
Higher levels of inflammatory markers at age 9 linked to an 81% increased risk of developing depression at age 18.
“Data from seven randomized controlled trials in people that were ill and depressed showed a significant antidepressant effect of anti-cytokine (anti-inflammatory) treatment compared with placebo. Further analysis showed that the antidepressant effect was not associated with improvement in primary physical illness.”
Episode
Stuart Phillips, PhD, on Building Muscle with Resistance Exercise and Reassessing Protein Intake
“As Dr. Phillips says, it's during recovery that "the good stuff happens" – the building of muscle and repairing of damage. Building muscle and maintaining function and strength in youth and midlife can forestall the inevitable periods of disuse and disease that occur throughout life and increase with aging.”
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