BDNF response in obese subjects is better under in high-intensity conditions rather than moderate-intensity: addressing cognitive dysfunction in obese
“Similarly, although acute high-intensity interval exercise induced greater blood lactate and plasma cortisol levels than continuous moderate-intensity exercise, obese subjects produced less blood lactate, but showed no difference in cortisol than normal-weight subjects.”
Aerobic exercise benefits people with depression, especially those whose symptoms are more severe.
“Depression, often referred to as major depressive disorder in the clinical or research setting, is characterized by profound sadness, fatigue, altered sleep and appetite, and feelings of guilt or low self-worth.”
High-dose vitamin D supplementation (4,000 IU) improved visual memory but low-dose vitamin D (400 IU) did not.
“Randomized controlled trial finds that high dose vitamin D supplementation (4,000 IU/day) for 18 weeks improves visual memory in healthy adults but low-dose vitamin D (400 IU/day) does not.”
Scientists combine neurocognitive training with aerobic exercise to leverage brain-derived neurotrophic factor and prevent disability in schizophrenia
“[...] > McEwen said that in the second study, the amount of BDNF increased 35 percent in the group that had participated in both cognitive training and exercise -- and half of that increase occurred within the first two weeks of the study.”
Menopausal hormone therapy accelerates tau protein buildup in brain regions linked to Alzheimer's in women over 70, potentially contributing to their higher vulnerability to the disease.
“According to some estimates, Alzheimer's disease will affect nearly 14 million Americans by 2060, with women comprising two-thirds of those cases. Research indicates that this disparity arises from the buildup of tau, a protein linked to cognitive decline, which occurs earlier and progresses more rapidly in women.”
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Can caloric restriction supplements mimic fasting? | Dr. Mark Mattson
“Dr. Mattson cautions against relying on mimetics; rather he recommends exercising, fasting, eating a healthy diet, and keeping the brain engaged as the best strategies for maintaining cognitive health. In this clip, Dr. Mark Mattson discusses the pros and cons of calorie restriction mimetics.”
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How Statin Benefits, Side Effects, and Alternatives Compare
Dr. Peter Attia explains statin benefits, blinded symptom evidence, cognition limits, Zone 2 testing, and nonstandard sterol monitoring.
Episode
The Longevity & Brain Benefits of Vigorous Exercise
“Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial - In sedentary middle-aged adults, 2 years of regular exercise improved heart function and reduced heart stiffness, potentially lowering future heart failure risk.”
Strawberry consumption boosts thinking speed and lowers systolic blood pressure by 3% in older adults.
“The researchers measured the participants' cognitive function using standard tests and tracked markers of heart health, including blood pressure, waist size, blood lipids, and antioxidant levels.”
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