A small study found that humans restricted to 11-hour per day eating schedule lost 3.5% body weight, improved energy, and sleep.
“Previous studies have shown the positive effects have to do with the body's internal clocks (called circadian rhythm) which regulate everything from metabolism to hormone production to repairing damage. Eating late in the evening throws off the internal clocks and wreaks havoc on metabolism.”
Episode
Low-Carb Lemon Tart Dessert (High Citrate & Choline)
“Citrate also gets converted into acetyl CoA, which is one of two precursors for the neurotransmitter acetylcholine. Acetylcholine is important for REM sleep, learning, and memory. The other precursor for acetylcholine is choline!”
Episode
Ruth Patterson, PhD, on Time-Restricted Eating in Humans & Breast Cancer Prevention
“Circadian rhythms modulate a wide array of physiological processes, including the body’s production of hormones that regulate sleep, hunger, metabolism, and others, ultimately influencing body weight, performance, and susceptibility to disease.”
Natural daylight during office hours improved blood sugar stability and shifted fuel use toward fat in adults with type 2 diabetes.
“Still, the findings suggest that something as simple as access to daylight at work could support blood sugar stability in people with type 2 diabetes. In this clip, I explain how HIIT, circadian-timed eating, and quality sleep improve metabolic health and reduce chronic disease risk.”
Episode
How To Use Coffee To Live Longer (Full Guide & Research)
“Controlled laboratory studies confirm caffeine consumption within three hours of bedtime results in disrupted sleep patterns. Practical recommendations include limiting coffee intake to the early part of the day—ideally ceasing caffeine consumption at least 8–10 hours before bedtime.”
Episode
Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
“Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging.”
Traumatic brain injury (TBI) can nearly double a person's risk for dementia.
“There are many diet and lifestyle factors that can lower a person's risk for Alzheimer's particularly if they have the apoE4 allele including diet high in vegetables, fruit and wild salmon, good sleep, low alcohol intake, and no smoking.”
Obesity can break down our protective blood brain barrier resulting in problems with learning and memory: overactivity of adenosine in obesity
“[...] > In the brain, adenosine is a neurotransmitter that helps us sleep and helps regulate our blood pressure; in the body it's also a component of the cell fuel adenosine triphosphate, or ATP.”
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