Psilocybin
“By inducing positively valenced, and sometimes even life-altering, psychological experiences, psilocybin may leave "quantifiable marks at the molecular genetic [and] epigenetic level."”
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“By inducing positively valenced, and sometimes even life-altering, psychological experiences, psilocybin may leave "quantifiable marks at the molecular genetic [and] epigenetic level."”
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“This is observational evidence and does not prove that morning timing caused the difference. Dr. Rhonda Patrick also describes observational reports linking coffee intake with DNA-methylation patterns and younger estimates from some epigenetic-aging measures.”
In this clip, Drs. Levine and Patrick discuss lifestyle factors that accelerate epigenetic aging including smoking cigarettes or having a low omega-3 index.
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“In this clip, Drs. Levine and Patrick discuss new advances in cellular aging research that show it's possible to reverse aging and generate new stem cells from already differentiated cells. Dr. Levine also discusses parabiosis, a treatment that involves giving old mice an infusion of plasma from young mice, and how it may reverse the cellular changes that accumulate during aging.”
“Learn more about epigenetic age acceleration in these clips featuring epigenetics experts Dr. Steve Horvath and Dr. Morgan Levine. View full publication. Learn more about epigenetic aging in our overview article.”
“Epigenetic modifications include the addition and subtraction of methyl groups, naturally occurring processes that regulate gene expression. These changes are quantifiable and serve as a means to gauge biological age, which is often different from chronological age.”
“Monocytes use a lot of nicotinamide adenine dinucleotide (NAD+), which is an important energy source for cells. The authors suggested this decrease in monocytes and subsequent increase in NAD+ may be responsible for the reversal of epigenetic aging.”
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“Among the 51 participants included in the methylation analysis, 4,000 IU per day was associated with a 1.85-year decrease in Horvath epigenetic age compared with placebo, while 2,000 IU affected a different methylation clock.”
“However, findings from a new study suggest that some survivors of childhood cancer are genetically susceptible to experiencing accelerated epigenetic aging. Epigenetic age acceleration is a phenomenon that occurs when a person's epigenetic age exceeds their chronological age.”
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“Recognition of this phenomenon has given rise to the concept of biological age, sometimes referred to as phenotypic age, generally recognized as a measure of a person's physiological and functional state.”
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