Search results for autophagy

“Dr. Guido Kroemer on autophagy (a cellular phenomenon triggered by aspects of the metabolic switch). Learn more about Dr. Dominic D'Agostino ‪Dominic D'Agostino‬ - ‪Google Scholar‬. Dominic D'Agostino, Ph.D. | Molecular Pharmacology and Physiology | USF Health.”

“Sirtuins utilize NAD+ to perform the process of deacetylation to control the activation of genes involved in energy metabolism, autophagy, circadian rhythms, DNA repair, cell survival, and more.”

“Although a person's genes play a pivotal role in whether they develop diabetes, lifestyle factors—like diet, exercise, and body weight—influence their risk, too. A recent study found that lifestyle interventions reduce the risk of developing diabetes, especially among those at high genetic risk.”

“These findings suggest an adaptive increase in gray matter volume occurs with sleep restriction, but caffeine impairs this adaptation. Caffeine may have beneficial effects on the body, however, such as boosting autophagy. Learn more in this Aliquot featuring Drs.”

“Several genes involved in mitochondrial dynamics and autophagy showed increased activity after eight weeks, while mitophagy-related genes did not clearly change. Most related protein markers also did not clearly change.”

“All the treated mice exhibited high levels of lactate dehydrogenase and creatine kinase – indicators of tissue damage. Some of the mice treated with hydroxychloroquine and metformin exhibited signs of increased autophagy in their hearts, livers, and kidneys.”

“These pathways are dysregulated in obesity and type 2 diabetes. The TOR pathway senses amino acid concentrations and regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.”

“Spermidine is a polyamine compound that may increase health span due to its ability to induce autophagy, the process by which the body removes damaged and dysfunctional cells. In animal models, spermidine supplementation has been shown to prevent memory loss.”

“In this way, long-term exercise training leads to more and healthier mitochondria. Mitophagy is a similar process to autophagy, which is enhanced during intermittent fasting or periods of low energy availability.”

“Drinking coffee is linked with reduced disease burden and increased lifespan, possibly due to coffee's ability to induce autophagy. A recent study suggests that coffee consumption improves vascular function in people with hypertension.”