FoundMyFitness library
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“When we engage in high-intensity exercise, our muscles become mini biochemical laboratories, synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) in the brain.”
“Multiple age-related inputs can keep innate immune pathways active, including the senescence-associated secretory phenotype, mitochondrial damage and oxidative stress, debris released by injured cells, visceral adipose tissue inflammation, chronic infections, increased intestinal permeability, and dysbiosis.”
“If you focus on eating multiple protein-containing meals each day and are thoughtful about your sources, it's likely you'll meet daily protein needs and thrive, whether your goal is gaining more muscle or just staying strong into your later years.”
“Brighter days can support cognition and function in older adults Whole-day lighting of approximately 1,000 lux produced model-based relative reductions of 5% in cognitive decline, 19% in depressive symptoms, and 53% in the increase in functional limitations, compared with customary lighting near 300 lux, in a cluster-randomized trial across 12 elder-care facilities.”
“In a recent double-blind placebo-controlled trial involving 27 healthy older adults (average age, 62 years) with at least one risk factor for diabetes, each of the study participants engaged in three 45-minute aerobic exercise training sessions per week for 12 weeks using a treadmill, stationary cycle, or elliptical machine.”
“Unlike chemicals that are rapidly eliminated in urine, some long-chain PFAS undergo biliary excretion and intestinal reabsorption, contributing to biological half-lives measured in years and the nickname “forever chemicals.” PFAS exposure may increase the risk of cancer, liver damage, and immune system impairment.”
“In an attempt to control for the healthy user bias (the possibility that people who take multivitamins may have better lifestyle habits than nonusers), the statistical analyses were adjusted for confounding factors like age, sex, education, alcohol and tobacco use, BMI, physical activity, diet quality, family history of cancer, and the use of other supplements.”
“Compared with no resistance training, 90–119 minutes per week was associated with a 13% lower rate of death from any cause, a 19% lower rate of cardiovascular death, and a 27% lower rate of neurological disease death after accounting for aerobic activity and other health and lifestyle factors.”
“Using isotope tracers that allowed them to distinguish NAD+ made directly from NR or NMN versus NAD made from nicotinamide, NR, or NMN, they found that a low oral dose of the precursors (50 milligrams per kilogram body weight, mg/kg/bw) produced very low levels of NAD+ made directly from NR and NMN in the liver but not in other tissues.”
“In a study involving diet-induced diabetic mice, injection of 500 milligrams per kilogram of body weight (mg/kg/bw) of nicotinamide mononucleotide administered for seven days enhanced insulin sensitivity and improved glucose intolerance compared to that observed among mice not given nicotinamide mononucleotide.”