Related Episodes for Axel Montagne, Ph.D. on Blood-Brain Barrier Dysfunction in Alzheimer’s Disease and Dementia

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“These events are recapitulated in both exercise and sauna, providing a potential explanation for the sleep-inducing effects of the two activities. In this clip, Dr. Matthew Walker explains how sleep and sauna may induce sleep through their short-term pro-inflammatory effects.”

“Heat stress activates molecular chaperones that help fold damaged proteins and maintain proteostasis, while heat therapy may also influence vascular and metabolic pathways relevant to cognitive aging. A prospective Finnish study followed 2,315 middle-aged men for a median of 20.7 years.”

“A small randomized trial also found that regular didgeridoo practice improved daytime sleepiness and reduced the apnea-hypopnea index, illustrating how upper-airway muscle training may help some patients alongside established sleep-medicine care.”

“In 1,334 dementia-free adults with a mean age of 84, levels below 25 nanomoles per liter were associated with a 91 percent higher rate of all-cause dementia and a 128 percent higher rate of Alzheimer's dementia over seven years.”

“Elevated biomarkers of inflammation, which are commonly observed in people who have depression, chronically activate the body's inflammatory response system, promoting the development of depressive symptoms and inducing changes in brain and neuroendocrine function.”

“Nicotinamide riboside and nicotinamide mononucleotide, molecules commonly referred to as NAD+ "boosters," exert beneficial effects on the brain, especially in the setting of vascular dementia.”

“Parkinson's disease is a progressive neurodegenerative disorder with no cure. The disease, which typically manifests later in life, is caused by the destruction of neurons that produce dopamine — a neurotransmitter best known for its role in motor, motivation, and pleasure control.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.