How changes in time are a stressor in bipolar disorder | Charles Raison

Parent Episode: Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia

NPAS2, a gene polymorphism involved in circadian rhythm regulation, is also associated with the risk of bipolar disorder. People with bipolar disorder are sensitive to fluctuations in circadian patterns, including sleep deprivation and time zone changes. Chronotherapy, which involves maintaining regular sleep/wake cycles, has been used as a treatment for bipolar disorder. In this clip, Dr. Charles Raison describes how changes in time zones or sleep/wake patterns can be a stressor for people with bipolar disorder.

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