Episodes

A diminished interferon response drives poor outcomes in COVID-19 | Roger Seheult

Posted on March 10th 2021 (about 3 years)
Views: 4978

In this clip, Dr. Roger Seheult describes how a diminished interferon response drives poor outcomes in COVID-19.

Caloric restriction vs. periodic fasting and the importance of re-feeding after a fast

Posted on July 15th 2019 (almost 5 years)
Views: 4956

Dr. Valter Longo explains the difference between caloric restriction and periodic fasting and highlights the importance of refeeding after a fast.

Aerobic exercise alters tryptophan and kynurenine metabolism (beneficial for depression)

Posted on April 9th 2022 (about 2 years)
Views: 4919

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

The connection between Alzheimer’s disease and insulin resistance | Peter Attia

Posted on February 11th 2020 (about 4 years)
Views: 4918

In this clip, Dr. Peter Attia explains his position on the relationship between insulin resistance and Alzheimer’s disease risk.

Is the RDA for protein too low? | Dr. Stuart Phillips

Posted on July 10th 2022 (almost 2 years)
Views: 4918

In this clip, Dr. Stuart Phillips discusses his concerns regarding the current protein recommended dietary allowances.

Sauna use and heat for strength preservation (anti-atrophy effect) | Rhonda Patrick

Posted on August 12th 2020 (over 3 years)
Views: 4911

In this clip, Dr. Rhonda Patrick discusses how heat can be used to increase muscle strength and counteract muscle wasting.

Lack of deep sleep linked with amyloid-beta build up in Alzheimer's disease | Matthew Walker

Posted on July 12th 2019 (almost 5 years)
Views: 4885

Dr. Matthew Walker describes the role that sleep plays in modulating the accumulation of amyloid-beta accumulation in the brain.

How sauna mimics cardiovascular exercise: a comparison to stationary bike | Rhonda Patrick

Posted on August 12th 2020 (over 3 years)
Views: 4854

In this clip, Dr. Rhonda Patrick describes how the physiological effects observed during sauna use are comparable to those that occur during physical exercise.

Can young stem cells reverse epigenetic age? | Steve Horvath

Posted on December 30th 2020 (over 3 years)
Views: 4816

Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, a fascinating phenomenon that offers promise for the idea of rejuvenation in humans.

APOE4 gene and associated risk for Alzheimer's disease | Dale Bredesen

Posted on July 12th 2019 (almost 5 years)
Views: 4770

Dr. Dale Bredesen describes the risks associated with APOE4 and identifies strategies for mitigating that risk.

Sauna use, depression and addiction — the dynorphin thermoregulatory connection | Roland Griffiths

Posted on November 5th 2019 (over 4 years)
Views: 4752

In this clip, Dr. Rhonda Patrick describes how sauna use activates the Salvinorin A pathway, potentially ameliorating symptoms of depression and opioid addiction.

Introduction to sulforaphane and its precursor glucoraphanin | Jed Fahey

Posted on January 17th 2020 (over 4 years)
Views: 4739

Dr. Jed Fahey describes how sulforaphane was discovered, how it is produced in plants, and the mechanisms by which it produces health effects in humans.

Increasing protein for longer-term sustainability of a ketogenic diet | Dominic D'Agostino

Posted on May 25th 2020 (almost 4 years)
Views: 4739

In this clip, Dr. Dominic D'Agostino describes different approaches that allow the ketogenic diet to be more accessible.

Neurological disorders and migraines | Dominic D'Agostino

Posted on May 21st 2022 (almost 2 years)
Views: 4701

In this clip, Dr. Dominic D'Agostino describes how nutritional ketosis may support the treatment of neurodegenerative and other brain disorders.

Lifestyle factors that affect Alzheimer’s risk for APOE4 carriers | Peter Attia

Posted on February 11th 2020 (about 4 years)
Views: 4692

In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss the unique dietary and lifestyle considerations for carriers of the APOE4 gene variant.

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