Lack of deep sleep linked with amyloid-beta build up in Alzheimer's disease | Matthew Walker

Parent Episode: Dr. Matthew Walker on Sleep for Enhancing Learning, Creativity, Immunity, and Glymphatic System

During sleep, the brain activates the glymphatic system, a self-cleaning process that rids the brain of metabolic byproducts. One of these byproducts is amyloid-beta, a toxic protein that aggregates and forms plaques in the brain with age and is associated with Alzheimer's disease. Poor sleep promotes the build-up of amyloid-beta, which, in turn, promotes poor sleep, creating a vicious cycle that has direct effects on brain health. In this clip, Dr. Matthew Walker describes the role that sleep plays in modulating the accumulation of amyloid-beta accumulation in the brain.

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