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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.
Daily coffee drinking and Alzheimer’s risk.
Study suggests that a higher lifetime coffee intake is likely to contribute to lowering the risk of AD or related cognitive decline by reducing pathological cerebral amyloid deposition. 1
In a randomized-controlled trial, consumption of dark roast coffee brew (500 ml/day) for 1 month caused a 23% reduction in DNA damage in white blood cells compared to baseline levels. 1
Coffee consumption may lower the risk of certain cancers up to 20% and type 2 diabetes and Parkinson’s disease up to 30%. 1
6 cups of coffee per day increases plasma homocysteine concentrations. 1
Comparing types of coffee: beans of coffee robusta have a higher polyphenol content than arabica beans but robusta also has more caffeine per bean. 1
Comparisons of curcumin bioavailability.
Piperine, found in black pepper, can increase the bioavailability of curcumin by 20-fold. 1
Crystalline curcumin in a micronized form can increase bioavailability by 28-fold. 1
Micellar curcumin (NovaSOL® Curcumin) was 277‐, 114‐, and 185‐fold more bioavailable than native curcumin in women, men, and all subjects, respectively. 1
Does curcumin blunt the beneficial effects of exercise like high-dose vitamin C or metformin?
Reducing saturated fat intake has been shown to lower ApoB in RCTs. 1
Lowering carbohydrate (26% E) intake and increasing saturated fat increases LDL large particles but lowers small LDL. 1
Inclusion of one avocado per day as part of a moderate‐fat, cholesterol‐lowering diet has LDL‐C, LDL‐P, and non‐HDL‐C lowering effects. 1
APOE4 carriers had greater reductions in apolipoprotein B and plasma cholesterol than E3/E3 subjects after replacing saturated fats with low glycemic carbohydrates on a lower-fat diet. 1
Special considerations when considering fasting for women.
Alternate day fasting may adversely affect glucose tolerance in nonobese women but not in nonobese men. 1
Sex hormones given exogenously increased ketones and betahydroxybutyrate at the 36-hour mark in both pre and postmenopausal women. 1
Being researched: on-going randomisation, double-blind placebo-controlled study investigates the effect of menaquinone-7 (MK-7) supplementation on progression of aortic valve calcification. 1
Phylloquinone (vitamin K1) and menaquinone (vitamin K2) association with incidence of coronary heart disease (CHD), all-cause mortality, and aortic calcification. 1
L-carnitine (2 g/day) significantly reduced Lp(a) levels. 1
Gene-dependent differences in response to aspirin: minor allele carriers of rs3798220 had higher Lp(a) and benefited more from an aspirin than non-carriers. 1
Higher serum total cholesterol is associated with a reduced PD risk in a dose-dependant manner. 1
Lower serum LDL cholesterol is associated with increased Parkinson’s disease. 1
FDA databases found that neurological disease was reported more often for lipophilic statins that more readily cross the blood-brain barrier, than for hydrophobic statins. 1
Beneficial effects of oral coenzyme Q10 administration have been found in animal models for Parkinson’s disease. 1
Does taking direct antioxidants nullify benefits from lifestyle habits such as sauna, exercise, fasting, broccoli sprouts and others?
Using a continuous glucose monitor when you don’t have diabetes.
My thoughts on moringa powder in my diet. 1
Fish oil (omega-3 fatty acids) lowers postprandial triglyceride levels by 16% to 40% in a dose-dependent fashion. 1
Using ketone esters as an adjunct to medication for neurodegenerative diseases like Parkinson’s and Alzheimer’s. 1
Magnesium threonate 1,500-2,000 mg each day for 12 weeks improved cognitive ability relative to placebo. 1
Omega-3 DHA and prostate cancer.
Collagen powder in smoothies.