Related Episodes for Dr. Longo’s top 5 biomarkers for longevity and biological age | Valter Longo

“There is so much to say when we talk about the NRF2 pathway and isothiocyanates like sulforaphane that we had to pack it into 47 minutes and break it into a few key sections. Key sections: For a more in-depth breakdown click the timeline link at the top of this page!”

“Older adults can have anabolic resistance and may need more protein per meal to reach a leucine threshold; Dr. Schoenfeld discusses roughly 2–3 grams of leucine as a flexible estimate, not a hard cutoff or a reason everyone needs isolated leucine.”

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“A standard multivitamin may support selected older adults by filling dietary gaps, and population surveys show that many people consume less than estimated requirements for nutrients such as magnesium, calcium, and vitamins A and C.”

“In this clip from Dr. Rhonda Patrick's presentation at the Vibrant Wellness Longevity Summit, she explains how the Omega-3 Index measures EPA and DHA in red-blood-cell membranes as a longer-term marker of omega-3 status.”

“Lutein and zeaxanthin also have evidence in age-related eye disease, although the AREDS2 trial did not find an additional reduction in progression to advanced macular degeneration in its primary comparison. Magnesium and creatine address different needs.”